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ADC Summit 2016

SAE Media Group proudly presents the return of the 5th annual ADC Summit to London in 2016!


With the FDA's recent approval of ADC's Adcetris® and Kadcyla ® , the industry has never been moving faster. With around 10 new ADC commercial launches over the coming decade, the report says the overall market will be worth USD 10 billion annually by 2025* and with most ADC research currently only in pre-clinical stages, we are yet to see the full market potential that ADCs are to contribute to the treatment of cancer. In an attempt to develop successors to Adcetris® and Kadcyla ® , the pharmaceutical industry is making every effort to produce the best next generation of ADCs by pioneering new approaches to eliminate cancer stem cells. As a result new innovations in conjugation methods and linker technology are bursting into the clinic at a rapid rate.


The introduction of second wave technology has seen a shift in industry from randomised cross linking technology to site directed technology, which has influenced a number of novel site specific conjugation techniques which have further influenced the next generation of ADCs. SAE Media Group's 5th annual ADC Summit brings you timely discussions to overcome ongoing challenges, including how to improve the therapeutic index of your ADC. Our 2-day event will provide a comprehensive analysis of the various approaches with the next generation ADCs. The conference will also focus on how to screen for optimal site of conjugation and offer some insight into how ADC can work in harmony with the field of oncology.


*http://www.prnewswire.com/news-releases/global-antibody-drug-conjugate-market-outlook-2020-300178206.html
 

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Mechanisms of actions

• The range of payload types commercially
available and their mechanism of actions
• Payloads at the discovery or development
stages

David E. Thurston

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson

Paul Jackson, Project Manager, Femtogenix

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10:00

Morning Coffee

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10:15

Molecular modelling technique

• Molecular modeling approaches to
payload discovery
• Designing maximum cytotoxicity into
payloads

David E. Thurston

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson

Paul Jackson, Project Manager, Femtogenix

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11:15

Morning Coffee

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11:30

Design and engineering of payloads

• Engineering payloads to not release
prematurely
• Strategies to minimise the hydrophobicity
• Ensuring maximum resistance to
P-glycoprotein pumps in payload design

David E. Thurston

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson

Paul Jackson, Project Manager, Femtogenix

Paul Jackson

Paul Jackson, Project Manager, Femtogenix

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12:30

End of workshop

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13:30

Registration

Richard Denk

Richard Denk, Head Containment Group, SKAN AG

Martin Glaettli

Martin Glaettli, Sales Engineer , SKAN AG

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14:00

What does containment mean for very low

• Containment in low nanogram levels
requires a new approach how to design the
containment and the process
• What technologies are on the market
• How to design the containment for the
API production as well as for the aseptic
processing

Richard Denk

Richard Denk, Head Containment Group, SKAN AG

Martin Glaettli

Martin Glaettli, Sales Engineer , SKAN AG

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16:00

Afternoon Tea

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16:30

Case study on a low OEL aseptic processing

• Important considerations and parameters
during design of low OEL aseptic processing
• How to combine EHS and GMP
• Final design implementation

Richard Denk

Richard Denk, Head Containment Group, SKAN AG

Martin Glaettli

Martin Glaettli, Sales Engineer , SKAN AG

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17:30

End of workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Rakesh Dixit

Rakesh Dixit, Vice President, R&D, Global Head, Biologics Safety Assessment, MedImmune Inc

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9:10

Advancement in antibody drug conjugates: A step closer to magic bullets in war against cancer

Rakesh Dixit

Rakesh Dixit, Vice President, R&D, Global Head, Biologics Safety Assessment, MedImmune Inc

• The 5 Rs of ADCs: the right target, the right linker, the right warhead, the right antibody, the right site of conjugation
• Recent developments with site-specific conjugation improving the therapeutic index of ADCs
• Exploring how reducing hydrophobicity of homogeneous ADCs can improve therapeutic index
• Discussing how the stability of the linker  can improve therapeutic index
• Discussing the on and off-target toxicity issues
• Clinical Development of ADCs
 

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9:50

Warheads for targeted therapies of cancer: strategies for designing and efficient synthesis of DNA cross-linkers

Iontcho  Vlahov

Iontcho Vlahov, Vice President of Discovery Chemistry, Endocyte, Inc.

• Some DNA cross-linkers are too toxic to be used as antineoplastic agents; instead, they are excellent candidates for the design of ligand-drug conjugates for cancer targeting.
• New concept for design of DNA cross-linkers.
• Efficient total synthesis of cross-linker derivatives for conjugation.
 

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10:30

Morning Coffee

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11:00

Development of best-in-class, homogeneous ADCs for highly effective and safer cancer therapy

Roger Beerli

Roger Beerli, Chief Scientific Officer, NBE Therapeutics

• Sortase-mediated antibody conjugation (SMAC™): a robust and efficient means to attach toxic payloads to antibodies.
• Highly site-specific conjugation yields homogenous drug product with defined efficacy, PK properties and safety profile.
• Peptide-based linker structure circumvents IP issues and provides superior serum stability.
• In vivo data on lead ADCs generated using site-specific SMAC™-technology will be presented
 

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11:40

Preclinical efficacy of a novel anti-C4.4a (LYPD3) antibody drug conjugate BAY 1129980 for the treatment of lung cancer

Joerg Willuda

Joerg Willuda, Senior Scientist, Bayer

• C4.4a (LYPD3) is a novel targeting antigen overexpressed in several cancer indications
• We will present the design of BAY 1129980 employing a novel auristatin
• We will discuss the in vitro and in vivo efficacy profile
• Phase 1 clinical studies are ongoing (NCT02134197)
 

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12:20

Networking Lunch

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13:30

Producing Better ADCs Using ThioBridge™ Conjugation

Matthew  Bird

Matthew Bird, Bioconjugation Team Leader, Abzena

• Disulfide re-bridging conjugation to reduce ADC heterogeneity
• ThioBridge™ linkers provide stable conjugation
• PK profiles of ThioBridge™ ADCs vs maleimide conjugation
• Development of more efficacious ADCs
 

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14:10

Novel site-specific conjugation tools

Thomas Keating

Thomas Keating, Director, Biochemistry, Immunogen, Inc.

• N-terminal serine modification for antibody conjugation: SeriMabs
• Excellent in vitro activity achieved through site-specific conjugation
• Site-specific conjugates are stable and efficacious in vivo
 

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14:50

Afternoon Tea

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15:20

Expanding the scope of ADC targets through novel conjugation technologies

Sasha Koniev

Sasha Koniev, CEO & Co Founder, Syndivia

• APN linkers with increased serum stability
• New generation of DM1- and MMAE-based payloads
• Expanding the scope of ADC targets by fine-tuning the drug release mechanism
 

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16:00

Platform Technologies for Homogeneous and Versatile Protein Modification

Vijay Chudasama

Vijay Chudasama, Lecturer (Organic Chemistry and Chemical Biology), University College London

• Functional disulfide re-bridging
• Controlled dual “click” functionalisation
• Site-selective antibody conjugation
• Photodynamic therapy
• Reversible and irreversible cysteine modification
 

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16:40

Chairman’s Closing Remarks and Close of Day One

Rakesh Dixit

Rakesh Dixit, Vice President, R&D, Global Head, Biologics Safety Assessment, MedImmune Inc

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Mahendra  Deonarain

Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

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9:10

ADCETRIS® (brentuximab vedotin) developed to treat Hodgkin

Ashish Gautam

Ashish Gautam, Global Medical Lead - ADCETRIS, Takeda Pharmaceuticals

• Development of ADCETRIS® - Takeda and Seattle Genetics
alliance
• Exploring the mechanism pathway of ADCETRIS®
• Data published to date from ADCETRIS® registration studies
• Ongoing ADCETRIS® clinical development

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9:50

Predicting tissue distribution and clearance of antibody formats to improve selectivity of targeted therapies

Ben-Fillippo  Krippendorff

Ben-Fillippo Krippendorff, Principal Scientist , Roche Pharmaceuticals


• Estimating the tissue distribution of antibodies and antibody fragments based on plasma pharmacokinetics
• Estimation of ADC distribution and tissue specific clearances that influence the therapeutic window
• Optimise biotherapeutic modalities with optimal biodistribution properties to target (and avoid) specific tissues
 

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10:30

Morning Coffee

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11:00

Impact of drug loading on ADC target binding and cytotoxicity

Debra Meyer

Debra Meyer, Senior Principal Scientist, Pfizer

• Case studies will be presented demonstrating the impact of different levels of drug loading on ADC target binding and cytotoxcity

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11:40

Developments in high potency API manufacturing

Richard Denk

Richard Denk, Containment Sales, SKAN AG

  • What does containment mean for very low OEL’s
  • How to design the containment for the
    API production as well as for the aseptic
    processing
  • Case study on a low OEL aseptic processing
    solution
  • clock

    12:30

    Networking Lunch

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    13:30

    Engineering and development of novel immunotargeted nanotherapeutics

    Daryl Drummond

    Daryl Drummond, Vice President, Discovery , Merrimack Pharmaceuticals Inc

    • Engineering considerations for a novel antibody directed nanotherapeutic
    • Target expression and demonstration of targeting
    • Preclinical demonstration of activity and altered tox profile
    • Diagnostic development and clinical trial design for upcoming Phase I
     

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    14:10

    The design, synthesis and scale-up of an ADC tubulysin payload

    Jeremy Parker

    Jeremy Parker, Principal Scientist, AstraZeneca

    • Development of novel ADC payloads based on Tubulysins
    • Identification and development of synthetic routes
    • Scale up of chemistry to deliver material for toxicology and clinical studies
     

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    14:50

    Afternoon Tea

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    15:20

    Challenges and lessons learnt in ADC CMC development and outsourcing

    Jens Lohrmann

    Jens Lohrmann, Senior Global Program Manager, Translational Clinical Oncology, Novartis

    • Buy vs. make: considerations and critical success factors
    • Scale-up and site transfer of a conjugation process with impact on key product quality attributes: case studies
    • Analytical transfers: considerations and lessons learned from a challenging assay transfers
     

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    16:00

    FDCs (Fragment Drug Conjugates): A unique drug class or just smaller ADCs?

    Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

    • Using optimised single chain Fvs to obtain high DAR
    • Impact of drug/linker structure on FDC properties
    • Dosing, PK and penetration issues
     

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    16:40

    Chairman’s Closing Remarks and Close of Day Two

    Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific Officer, Antikor Biopharma Ltd.

    Sponsors and Exhibitors

    Official Media Partner

    Supporters

    Workshops

    ADC Payloads: Availability and Mechanisms of Action

    ADC Payloads: Availability and Mechanisms of Action

    Holiday Inn Kensington Forum
    25 May 2016
    London, United Kingdom

    Preliminary list of attendees - 2016

    Download

    Interview with Mahendra Deonarain

    Download

    Sponsors and Exhibitors


    Abzena

    Sponsors and Exhibitors
    http://www.abzena.com

    Abzena offers a suite of complementary services and technologies. Its range of technologies include immunogenicity assessment, antibody drug conjugation, protein engineering, PEGylation, cell line development , GMP manufacturing and a range of bespoke assays to enables the development of better biopharmaceuticals which will have a greater chance of reaching the market.


    Heraeus

    Sponsors and Exhibitors
    http://www.heraeus-chemicals.com/

    Heraeus’ Business line Pharmaceuticals is the specialist in cytotoxic agents for nearly 30 years. We hold globally a leading position in supply of precious metals based API as well as generic cytotoxic agents Heraeus comprehensive custom services is focused on the synthesis of highly potent compounds (precious metal compounds and small molecules) under high containment conditions and full GMP. In the field of Antibody-Drug-Conjugates our strengths is in payloads. For more details please visit our website www.heraeus-chemicals.com

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    ADC Review

    Official Media Partner
    http://www.adcreview.com

    ADC Review / Journal of Antibody-drug Conjugates (ISSN: 2327-0152) is an international publication combining professional social media with an online-only, hybrid open-access, peer reviewed journal. The Journal aims to serve the needs of a diverse community of individuals including academia, life sciences, pharma, (basic, translational and clinical) research, clinicians, along with regulatory affairs, government authorities and representatives from payers, and policy makers. Key information includes peer-reviewed articles, news features, discussions, blogs, and a knowledge center offering the latest and most relevant information about Antibody Drug Conjugates (ADCs), BiSpecific Antibodies, Site Specific Antibody Drug Conjugates, Small Molecule Drug Conjugates (SMDC), and Engineered Antibody Fragments. The purpose of the Journal is to present this information in an understandable and a useful format for all stakeholders.


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    PMR (www.pmrcorporate.com) is a British-American company providing market information, advice and services to international businesses interested in Central and Eastern European countries as well as other emerging markets. PMR's key areas of operation include business publications (through PMR Publications), consultancy (through PMR Consulting) and market research (through PMR Research ). Being present on the market since 1995, offering high international standards in projects and publications, as well as providing one of the most frequently visited and top-ranked websites, PMR is one of the largest companies of its type in the region.


    Mednous

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    http://www.MedNous.com

    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


    Pharmaceutical Technology

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    http://www.pharmaceutical-technology.com

    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.

    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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