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Therapeutic antibodies: From concepts to clinics
9 July 2013
Therapeutic antibodies: From concepts to clinics

 

Antibodies play a dominant role in the treatment of many life-threatening situations like cancer or autoimmune diseases due to their excellent safety/efficacy profile compared to other, conventional drugs. This masterclass will provide an introduction to therapeutic antibodies, pitfalls to be avoided in their development and strategies for their state-of-the-art design. In addition to the description of the current status new emerging developments and trends will be highlighted.

Masterclass agenda

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9:00

Registration & Coffee

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9:30

Welcome & Introduction

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9:45

Overview of Antibodies

  • The human immune system
  • A historical view on antibodies
  • Immunoglobulin structure
  • Immunoglobulin classes, subclasses and allotypes
  • Antibody generation in the human immune response
  • (Effector) functions, modulation of IgG halflife
  • Up- (and down-) sides of antibodies as therapeutic entity
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    11:15

    Morning Coffee

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    11:45

    Detailed View on Therapeutic Antibodies

  • Generation of monoclonal antibodies
  • Humanization
  • IP situation
  • Effect of posttranslational modifications on antibody function
  • Immunogenicity aspects
  • Regulatory overview
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    13:15

    Networking Lunch

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    14:15

    "Enhanced" Antibodies

  • Improvement by antibody combination
  • Effector function modulating antibody variants
  • Payloaded antibodies
  • Examples for improved 2nd generation antibodies
  • Outlook on 3rd generation antibodies/scaffolds

     

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    16:15

    Afternoon Tea

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    16:45

    Group Discussion

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    17:15

    Closing Remarks and Close of Master Class

    VENUE

    Holiday Inn Bloomsbury

    Coram Street, London, United Kingdom

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    Holiday Inn Bloomsbury

    Coram Street
    London WC1N 1HT
    United Kingdom

    Holiday Inn Bloomsbury

    Holiday Inn London-Bloomsbury is just 2 minutes' walk from the Tube at Russell Square station, for speedy connections across the capital. We're 10 minutes by bus from Eurostar connections at St Pancras station, and a 45-minute taxi ride from London Heathrow Airport. Check into your stylish Guest room, air-conditioned and connected to wireless Internet.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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