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Novel Linker Strategies
22 May 2012
Novel Linker Strategies
In Association With: Philochem

This workshop will provide attendees with an in-depth view in a variety of different strategies in discovering and developing antibody drug conjugate linkers. Led by the expertise and experience of Guilio Casi, attendees will be presented with case studies to learn from and develop linker technologies.

Why you should attend:
• Learn about current and future linker technologies
• Utilise the experience of an expert in the field
• Improve your understanding of linker strategies
• Evaluate past experiences and benefiting from lessons learnt
• Network with key industry professionals
 

 

 

 
About the Workshop Host: Giulio Casi, studied chemistry with focus in organic synthesis, at Florence University in Italy. After one year training in the medicinal chemistry department of Serono pharmaceutical research institute in Geneva, Switzerland, he joined the laboratory of Prof. Donald Hilvert in ETH Zurich, Switzerland, where he worked at the interface between chemistry and biology for the assembly of a semi synthetic enzyme. For this work Giulio Casi was awarded a PhD degree at the end of 2007. After completing enzymatic characterization and collaborative work with Prof. Dieter Seebach, in 2009 he joined the department of rare reagents at Roche Diagnostics in Penzberg, Germany, where he worked as a postdoctoral fellow on the development of synthetic antigens. Giulio Casi is co-author of several publications in peer-reviewed journals. Since November 2009 Giulio Casi joined Philochem AG where he is responsible for the development of novel targeted cytotoxics. His work involves, the engineering of innovative linkers for the controlled release of drugs in antibody drug conjugates, the discovery and application of novel protein chemistries, and the development of novel cytotoxic drugs.
   
Philochem

About Philochem: Philochem is a fully owned daughter company of Philogen and represents the Discovery Unit of the Philogen group and has discovered innovative methodologies for biotechnology product development:

• isolation of human monoclonal antibodies from large combinatorial libraries.
• development of armed antibodies (immunocytokines and antibody-drug conjugates).
• discovery and validation of vascular markers of pathology using a perfusion-based chemical proteomics approach.
• design, construction and screening of DNA-encoded chemical libraries of unprecedented quality and size.
 

These technologies are integrated into drug discovery programs. The most promising candidate products are further developed in the Siena-based Philogen facilities. Here production according to GMP standards and clinical trials are conducted with the aim of developing superior products for the imaging and treatment of serious angiogenesis-related diseases. Philochem has a proven track record in partnering activities, and is currently involved in several projects with leading pharmaceutical companies interested in Philochem’s innovative technology platforms.

   

 

Workshop agenda

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8:30

Registration & Coffee

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9:00

Welcome & Introductions

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9:10

An Introduction to Antibody-Drug Conjugates (ADCs): General Concepts and Historical Perspectives

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9:45

Case Study: Linkers and Payloads which have been used for advanced clinical development programs

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10:15

Internalizing vs. non-Internalizing Antibodies: challenges and opportunities

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10:45

Coffee Break

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11:00

Novel linkerless ADCs: Preclinical experience and industrial opportunities

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11:30

A critical analysis of challenges and opportunities for next-generation armed antibodies

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12:10

Discussion Session

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12:30

Close of Workshop

VENUE

Holiday Inn Kensington High Street

Wrights Lane, Kensington, London, W8 5SP, United Kingdom

A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
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Wrights Lane
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London
United Kingdom

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