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Anti-Arthritic Agents Conference
19 November - 20 November 2007
Anti-Arthritic Agents Conference

More than 146 million adults in developed markets suffer from arthritis or related rheumatic conditions. Existing therapies have failed to meet the overwhelming market demand, and the pharmaceutical industry is heavily invested in the search of effective treatments to these chronic conditions
    
SAE Media Group's 7th Annual Anti-Arthritic Agents Conference offers a unique opportunity to hear about the latest developments from industry leaders. 
      
Examine the latest developments in the research of therapeutics for Arthritic and Inflammatory indications, and listen to case studies from the leading companies in the field. Discussions will include novel therapeutics, new approaches and technologies and will look into product differentiation and extended efficacy to meet the demands of the market:  
  • The search for novel chemical agents for treatment of rheumatic diseases
  • Advancement on bone biomarkers and skeletal damage in rheumatoid arthritis
  • Recent pharmaceutical research on  pain mechanisms for arthritic diseases
  • Seeking greater efficacy in existing treatments   
       
Bringing together knowledge and expertise, it’s designed to create the perfect setting for the exchange of ideas and networking opportunities.
      

Confirmed speakers include:
  • Dr Stephen Myers, Medical Director, Musculoskeletal Programmes, Eli Lilly
  • Dr Amanda Proudfoot, Director External Collaborations, Merck Serono
  • Dr Wolfgang Albrecht, Chief Scientific Officer, C-A-I-R Bioscience
  • Dr Andrew Salzman, Chief Executive Officer, Inotek Pharmaceuticals
  • Prof Gabriel Panayi, Rheumatology, Kings College London
  • Dr Alison Kerr, Managing Director, Inflammations Discovery Services, MD Biosciences


This conference is aimed at: 

  • Medical Directors
  • Director of Rheumatology
  • Senior Scientists - Arthritis and Inflammation Research
  • Directors of Clinical Research
  • Senior Clinical Project Managers


PLUS A HALF DAY CONFERENCE EXECUTIVE BRIEFING:

Refinement of Biological Therapies for Inflammatory Diseases

                                                                                                                

For Speaking opportunities please contact Mamta Patel at mpatel@SAE Media Group-online.co.uk
For Sponsorship opportunities please contact Alia Malick at amalick@SAE Media Group-online.co.uk

Conference agenda

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8:30

Registration & Coffee

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9:00

The NF-B as a Potential Target for Therapy in Autoimmune and Inflammatory Diseases

Dr Rizgar A Mageed

Dr Rizgar A Mageed, Professor, Experimental Immunology, Bone Joint Research, The William Harvey Research Institute

  • The NF-kB complex is a major pathway for the signalling and induction of pro-inflammatory stimuli
  • The NF-kB complex is stimulated via two pathways, the canonical and alternative.
  • Blockade of either pathway with specific inhibitors can be beneficial to different inflammatory and autoimmune conditions
  • We propose the development of new specific inhibitors for the NF-?B pathways to treat inflammatory and autoimmune diseases
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9:40

Development of a gene therapy approach for treatment of rheumatoid arthritis

Dr David J Gould

Dr David J Gould, Senior Research Fellow and Honorary Lecturer, The William Harvey Research Institute

  • Collagen-induced arthritis is a robust and well-validated animal model for rheumatoid arthritis
  • Current research is aimed at understanding endogenous regulatory mechanisms that exist to curtail or dampen down immune and inflammatory responses
  • We have recently shown that indoleamine 2,3-dioxygenase (IDO) plays an important role in reducing severity of collagen-induced arthritis
  • We propose to address the question of whether the IDO pathway can be exploited in the therapy of rheumatoid arthritis
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10:30

Morning Coffee

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11:00

Collagen-induced Arthritis as a Probe for Understanding Disease Pathogenesis and Developing New Therapeutics

Richard O Williams

Richard O Williams, Senior Lecturer, Kennedy Institute Of Rheumatology Division

  • Plasmid DNA is a safe gene delivery vehicle for treatment of chronic inflammatory disease
  • We can achieve long-term regulated gene expression with a self-contained plasmid
  • Therapeutic effect with TNFa inhibitors expressed from plasmid DNA is demonstrated in the collagen induced arthritis model
  • How the components are being optimized to facilitate a gene therapy approach in the clinic will be discussed.
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11:30

Discussion

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12:00

Chairman’s Closing Remarks and Close of Workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Dr Nigel Boughton-Smith

Dr Nigel Boughton-Smith, Principal Scientist Discovery & Emerging Products, Discovery Bioscience, AstraZeneca

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9:10

EMERGING NEW BIOLOGIC THERAPIES: DRIVING FUTURE THERAPEUTIC STRATEGIES

Dr Brian Wong

Dr Brian Wong, Director, Rheumatology Discovery, Inflammation Disease Biology Area , Roche

  • The surge in biotherapeutics  - locating the un-met need
  • The search for steroid-action in chemical compounds
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    9:50

    THE CHEMOKINE SYSTEM PROVIDES MULTI-FACETED STRATEGIES FOR INFLAMMATORY DISEASES

    Dr Amanda Proudfoot

    Dr Amanda Proudfoot, Director, External Collaborations, Merck-Serono

  • Current status of development of oral small molecule receptor antagonists
  • Biological strategies
  • Can we learn from nature?
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    10:30

    Morning Coffee

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    11:00

    SMALL MOLECULE INHIBITORS OF T CELL COSTIMULATION VIA CD80 BLOCKADE

    Dr Neill Mackenzie

    Dr Neill Mackenzie, Senior Vice President, MediGene

  • Small molecule inhibitors of T cell costimulation via CD80 blockade
  • Novel, orally available compounds for inflammatory disease
  • Challenges of developing human-specific molecules
  • Preclinical models in RA and Psoriasis
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    11:40

    IMPROVED PRE-CLINICAL MODELS OF RHEUMATOID ARTHRITIS WITH CLINICALLY RELEVANT PATHOLOGY

    Dr Alison Kerr

    Dr Alison Kerr, Managing Director, Inflammations Discovery Services, MD Biosciences

  • Shortfalls of current pre-clinical models
  • Rapid pre-clinical models that maintain joint pathology
  • Relevant pre-clinical models
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    12:20

    Networking Lunch

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    13:50

    IKK2 INHIBITION IN PRECLINICAL MODELS OF RHEUMATOID ARTHRITIS

    Dr Elena Izmailova

    Dr Elena Izmailova, Senior Scientist, Millennium Pharmaceuticals

  • The need for mechanism based evidence for development of new therapeutics
  • IKK2 as a novel target
  • Biomarkers of IKK2 inhibition in arthritic models
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    14:30

    NOVEL CHEMICAL THERAPEUTIC AGENTS FOR TREATMENT OF RHEUMATIC DISEASES

    Dr Wolfgang Albrecht

    Dr Wolfgang Albrecht, Chief Scientific Officer, C-A-I-R Bioscience

  • Current status of development of protein kinase inhibitors for treatment of autoimmune diseases
  • Multiple activation mechanisms of protein kinases as a major hurdle for clinical development of small molecules?
  • Protein kinase phosphatases as alternative targets
  • Outlook compared to available and emerging biological therapies
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    15:10

    Afternoon Tea

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    15:40

    BIP-INDUCED REGULATORY CELLS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

    Prof Gabriel Panayi

    Prof Gabriel Panayi, ARC Professor, Rhuematology, Department of Rheumatology, Kings College London

    • BiP is an ER chaperone found in extra-cellular fluids
    • In humans BiP will:
    • o        Induce anti-inflammatory phenotype in human monocytes
      o        BiP-specific T-cell clones secrete TH2 cytokine
      o        Suppress T-cell proliferative responses
      • In Mice BiP will:
      • o        Prevent and treat CIA
        o        Induce regulatory cells
        o        Regulatory cells suppress CIA
        o        IL-4 necessary for induction/action BiP
        • BiP suppresses inflammation in RA SM tissue transplanted into SCID mice
        • ·         BiP potential new immunomodulator for RA
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    16:20

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Rizgar Mageed

    Rizgar Mageed, Professor, Experimental Immunology, Bone Joint Research, The William Harvey Research Institute

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    9:10

    OPPORTUNITIES FOR BONE ANABOLIC THERAPIES IN THE TREATMENT OF ARTHRITIS

    Dr Adrian Moore

    Dr Adrian Moore, Senior Group Leader, Pharmacology, UCB-Celltech

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    9:50

    RECENT TRENDS AND CHANGES IN THE DEAL MAKING ENVIRONMENT FOR ANTI-ARTHRITIS PRODUCTS

    John  Janes

    John Janes, Managing Consultant, PharmaVentures

  • A comparison of the environment for biologics and RA products
  • Deal values and structures: co development and co promotion clauses
  • The future competitive environment
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    10:30

    Morning Coffee

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    11:00

    BONE BIOMARKERS AND SKELETAL DAMAGE IN RHEUMATOID ARTHRITIS

    Dr Stephen Myers

    Dr Stephen Myers, Medical Director, Musculoskeletal Programs, Eli Lilly & Co

  • Using bone formation and resorption markers in clinical trials
  • Disease-related changes in cortical and trabecular bone
  • Therapeutic opportunities in the damaged skeleton
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    11:40

    INTEGRATION OF KINETICS, SAFETY AND EFFICACY EVALUATION IN PRECLINICAL ARTHRITIS STUDIES

    Anne-Marie Zuurmond

    Anne-Marie Zuurmond, Project Manager, TNO Pharma

  • (Limitations of) Existing in vitro and in vivo efficacy assays
  • Combining kinetics, safety and efficacy evaluation
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    12:20

    Networking Lunch

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    13:50

    MRI Assessment of Rheumatoid Arthritis

    Stephen Oakley

    Stephen Oakley, Professor of Rheumatology, Ixico

    • Novels compounds for the prevention of arterial thrombosis
    • Blocking the formation of blood clots mediated through inflammation without increasing bleeding risk
    • Biomarker development
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    14:30

    COMPOUND AND BIOLOGICS EVALUATION IN ANIMAL MODELS OF RHEUMATOID ARTHRITIS

    Dr Simon  Cruwys

    Dr Simon Cruwys, Team Leader, Research and Development, Respiratory and Inflammation, AstraZeneca

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    15:10

    Chairman’s Closing Remarks and Close of Conference

    Workshops

    VENUE

    Hesperia Victoria Hotel

    2 Bridge Place, Victoria, London, United Kingdom

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    Hesperia Victoria Hotel

    2 Bridge Place
    Victoria
    London SW1V 1QA
    United Kingdom

    Hesperia Victoria Hotel

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

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