Home
Delivery of Oligonucleotide-Based Drugs
9 June 2009
Delivery of Oligonucleotide-Based Drugs

The therapeutic use of chemically synthesized oligonucleotides was boosted when target gene suppression mediated by silencing RNA (siRNA)-induced RNA interference (RNAi) was first reported. This extended the repertoire of molecular mechanisms based on which oligonucleotides can be applied as molecular tools and drugs. Fundamental progress on the biological level, however, is still not reflected by solutions on the major technical hurdle, i.e. the efficient functional delivery of oligonucleotides to target cells and tissues in vivo.

With regard to the overall non-satisfactory methodology for oligonucleotide delivery it is not surprising that antisense oligonucleotides as a cargo moved back into the focus of current nucleic acid-based drug development and the search for suitable delivery technology.

This workshop aims to describe new mechanistic concepts for the cellular and intracellular delivery of oligonucleotides including siRNA and antisense oligonucleotides. We will attempt to derive new lessons and insights from examples of the successful delivery of oligonucleotides in vivo. Finally, a round-table-discussion is aimed to define the current state of knowledge and to draw conclusion for promising future directions and strategies of developing methodology for delivery.

About the Workshop Leader:

Georg Sczakiel is the director of the Institute of Molecular Medicine of the University of Lubeck and he has been working in the fields of antisense-RNA, ribozymes, antisense oligonucleotides and siRNA for twenty years. He received the diploma in chemistry at the University of Freiburg and his Ph.D. at the Max-Planck-Institute of Medical Research in Heidelberg. He continued his career in the field of HIV and HPV virology at the German Cancer Resarch Center where his mentor for thirteen years was the Novel laureate Prof. Harald zur Hausen.
Among his scientific activities Georg serves as an executive editor of Nucleic Acids Search and Chemie in unserer Zeit, he is guest executive editor of Current Pharmaceutical Design, and editorial board member of Oligonucleotides and the new journal Journal of Nucleic Acids. He was one of five co-founders of the Oligonucleotide Therapeutics Society (OTS).

Workshop agenda

clock

13:30

Registration & Coffee

clock

14:00

Welcome and Introductions

clock

14:10

KEYNOTE ADDRESS(ES): THE CURRENT STATE OF OLIGONUCLEOTIDE DELIVERY IN VITRO AND IN VIVO

  • Technology that failed so far
  • Technology currently being tested
  • New concepts and future strategies
  • clock

    14:50

    OLIGONUCLEOTIDE DELIVERY

  • Cell- and ligand-targeted modes
  • HTS-based search for delivery options
  • Examples teaching promising future directions
  • clock

    15:40

    Afternoon Tea

    clock

    16:00

    NEW LESSONS FROM BASIC RESEARCH FOR THE APPLICATION

  • Cellular uptake of naked nucleic acids
  • Intracellular trafficking and biological effectiveness
  • Improved delivery by novel chemistry
  • clock

    16:50

    DISCUSSION – ROUND-TABLE

  • The major technical problems to be solved
  • The role of novel chemistry
  • Does novel biology help to solve the delivery problem?
  • Is successful delivery related to the classes of oligonucleotide-based drugs?
  • clock

    17:00

    Close of Workshop

    VENUE

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51, London, United Kingdom

    A number of our clients have been approached by third party organisations offering to book hotel rooms. We would advise that you do not book through them as they are not representing the SMi Group. SMi Group books all hotel rooms directly. If you are approached by a third party organisation then please contact us before making any bookings. If you have already booked a hotel room using a third party organisation, we would highly recommend contacting the hotel you were booked into to ensure a booking has been made for you. We would also advise you to please check the terms and conditions of the booking carefully.
    HOTEL BOOKING FORM

    SAVE TO


    Outlook Calendar  OUTLOOK CALENDAR
    Google Calendar  GOOGLE CALENDAR
    ICal Calendar  ICAL CALENDAR
    Yahoo! Calendar  YAHOO! CALENDAR

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51
    London SW1E 6AF
    United Kingdom

    Crowne Plaza Hotel - St James

    HOTEL BOOKING FORM

    Title

    SubTitle
    speaker image

    Content


    Title


    Description

    Download

    Title


    Description

    Download

    Title


    Description


    Download


    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

    Event Title

    Headline

    Text
    Read More

    I would like to speak at an event

    I would like to attend an event

    Group Booking

    Please complete the below form and a member of SAE Media Group’s booking team will be in contact within 24 hours

    I would like to sponsor/exhibit at an event

    SIGN UP OR LOGIN

    Sign up
    Forgotten Password?

    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




    Forgotten Password

    Please enter the email address you registered with. We will email you a new password.

    Thank you for visiting our event

    If you would like to receive further information about our events, please fill out the information below.

    By ticking above you are consenting to receive information by email from SAE Media Group.
    Full details of our privacy policy can be found here https://www.smgconferences.com/privacy-legals/privacy-policy/.
    Should you wish to update your contact preferences at any time you can contact us at data.privacy@smgconferences.com.
    Should you wish to be removed from any future mailing lists please click on the following link http://www.smgconferences.com/opt-out

    Fill in your details to download the brochure

    By submitting this form you agree to our privacy policy and consent to receiving communications, you may opt out at any time.