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Animal Models of Pain: A Critical Assessment
24 May 2017
Animal Models of Pain: A Critical Assessment

 

The purpose of this workshop is to educate the audience on the various animal models used to evaluate analgesic drugs. Strengths, weakness and the clinical relevance of the models will be described with an emphasis on pain associated with osteoarthritis. Pain will be defined as a phenomenon and with regard to site, modality, electrophysiology, neuronal plasticity and affective state. The utility of pain biomarkers and their relationship to PK/PD will be introduced along with relevant drug targets and mechanisms.

Workshop LEADER

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Steven Kamerling

Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

Steve is a Registered Pharmacist and received his Pharmacy degree from Drake University. He then pursued graduate studies in Pharmacology and received a PhD from the College of Medicine at the University of Illinois. Steve became a postdoctoral fellow in Pharmacology at the University of Kentucky, College of Medicine from, later becoming a Research Associate in Veterinary Sciences. His research at the time focused on in vivo neuropharmacology of pain transmission and opioid and nicotine pharmacology. Subsequently, Steve joined the faculty of the School of Veterinary Medicine at Louisiana State University and achieved the rank of Endowed Professor at the time of his departure. He subsequently joined the Pharmacia & Upjohn Company (later becoming Pfizer then Zoetis) to pursue a career in drug discovery and has continued in that capacity since 1999. Steve is currently Therapeutic Area Head of Pain & Inflammation, Oncology, Cardiac Disease and Oncology. Steve’s research interests include animal models of pain, arthritis, inflammation, heart disease and the pharmacology of novel analgesics, NSAIDs, opioids and sedatives. He has also been active in evaluating novel, molecularly targeted therapeutics in spontaneous canine neoplasias, from a translational medicine perspective. Steve enjoys playing jazz guitar and singing in his free time.

Zoetis

Zoetis discovers, develops, manufactures and commercializes a diverse portfolio of animal health medicines and vaccines designed to meet the real-world needs of veterinarians and the livestock farmers and companion animal owners they support. With its more than 60 years of experience in animal health, Zoetis generated $4.8 billion in revenue in 2015 and sells products in over 100 countries. There are approximately 9000 Zoetis colleagues, with approximately 1,050 in Research and Development, and approximately 2800 field force members.

Workshop agenda

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8:30

Registration & Coffee

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9:00

Opening remarks and introductions

Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

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9:10

Defining the pain phenomenon

Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

  • Understanding pain associated with anatomical site, disease pathology, and its duration  
  • Clinical pain states, the role of inflammation, pain mediators 
  • Peripheral and central sensitization
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    9:50

    Animal models and pain

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

  • Models of spontaneous and evoked pain
  • Models of neuropathic, visceral, and cancer pain  
  • Models of affective pain behaviours
  • Drugs active in these models; why and why not
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    10:30

    Coffee

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    11:00

    Focus on osteoarthritis pain

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

  • Models of pain associated with osteoarthritis
  • Interpretation of efficacy and safety data 
  • Relevance of animal models to human clinical pain states
  • Analgesics that translate between human and animal pain models
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    11:40

    Current approach to use pain biomarkers

    Steven Kamerling, Therapeutic Area Head for Pain, Inflammation and Oncology, Zoetis

  • Pain biomarkers and their relationship to disease
  • Pain biomarkers and the effects of analgesics: PK/PD
  • Relevance of pain biomarkers in experimental and human clinical pain states
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    12:20

    Closing remarks

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    12:30

    End of workshop

    VENUE

    Copthorne Tara Hotel

    Scarsdale Place, Kensington, London, United Kingdom

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

    HOTEL BOOKING FORM

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