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Epigenetic Profiling
7 December 2010
Epigenetic Profiling

Overview

This SAE Media Group masterclass will explore the application of epigenetic profiling technology in pharmaceutical development.

Epigenetics is the study of the regulation of gene expression through non-sequence based factors. It is what links our primary gene sequencing to our environment allowing for differential gene expression, environmental gene modulation, reversible expression and provision of certain inheritable traits. Therapeutics for cancer, neurodegenerative and infectious diseases based on epigenetic targets are already in development and research is underway to explore the role for epigenetics in cardiovascular, metabolic and other diseases.

 


 

Masterclass Agenda

  • Background to epigentics
  • Epigenetics in oncology and regenerative medicine
  • DNA methylation patterning
  • Epigenetic regulation 
  • Chromatin remodelling
  • The landscape for future profiling technologies 
Pharmacogenomic approach to personalised medicine        

About the Masterclass Leader

 

Mark Eccleston is the Managing Director of OncoLytika Ltd. He has previously worked for ValiRx Plc – an epigenetics based oncology company listed on AIM – and is a director of ValiFinn – a Finnish CRO offering epigenetic profiling services. He has set up several innovative companies in the biotechnology and fast moving consumer goods sector working in project management, preclinical development and business development. He has a PhD in Polymer Chemistry and an MBA from the University of Cambridge.

 


 About the Company  

 

  OncoLytika Ltd. is developing an in-house portfolio of therapeutic and imaging products and provides consultancy services to the Pharma and Biotech sectors in the areas of preclinical development and formulation including outsourced project management. Additional activities include due diligence, business planning support including opportunity recognition, market assessment and marketing plan development. www.oncolytika.com


 

Masterclass agenda

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8:30

Registration and coffee

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9:00

Epigenetics: The link between genes and their environment

  • Introduction to epigenetics
  • DNA Methylation patterning
  • Histone Modifications and Chromatin structure
  • Profiling technologies
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    10:00

    Epigenetic regulation in stem cells and cancer

  • Epigentic regulation of transcription
  • Transcription and cancer
  • The cancer Epigenome
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    10:30

    Coffee

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    10:45

    The Commercial epigenetic landscape

  • Market overview
  • Key Players and technologies
  • Case Studies
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    11:45

    Emerging technologies and opportunities

  • Genome wide epigenetic profiling
  • Chromatin remodeling – therapeutic implications
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    12:30

    Discussion and questions

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    13:00

    Close of masterclass

    VENUE

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    Holiday Inn Bloomsbury

    Coram Street
    London WC1N 1HT
    United Kingdom

    Holiday Inn Bloomsbury

    Holiday Inn London-Bloomsbury is just 2 minutes' walk from the Tube at Russell Square station, for speedy connections across the capital. We're 10 minutes by bus from Eurostar connections at St Pancras station, and a 45-minute taxi ride from London Heathrow Airport. Check into your stylish Guest room, air-conditioned and connected to wireless Internet.

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