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ADC Payloads: Availability and Mechanisms of Action
25 May 2016
ADC Payloads: Availability and Mechanisms of Action

This workshop will focus on the variety of chemical and biological payloads available for attaching to antibodies,
and those in the discovery and/or development phase. Discussion will be based on how the structure and mechanism of action of payloads can affect their toxicities and clinical activities when attached to antibodies, and how the best payload can be identified for a particular cancer type and/or antibody.
 

Workshop LEADER

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David E. Thurston

Professor of Drug Discovery, King's College London

David Thurston is Professor of Drug Discovery in the Institute of Pharmaceutical Science at King’s College London. He has a first degree in pharmacy and a PhD in synthetic medicinal chemistry. David is one of the scientific co-founders of Spirogen Ltd (recently acquired by AstraZeneca), and acted as CSO for the company from its formation in 2000 until 2011. He is also a co-founder of Transcriptogen Ltd, which focusses on the discovery and development of small-molecule transcription factor inhibitors as oncology agents, and Femtogenix Ltd which is involved with the discovery of novel DNA Minor Groove Binding Agents (MGBAs) with potential application as ADC payloads. David has published widely in medicinal chemistry/chemistry journals, is author of the textbook “Chemistry and Pharmacology of Anticancer Drugs”, and Editor-in-Chief of the Drug Discovery book series of the Royal Society of Chemistry.

Workshop agenda

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8:30

Registration & Coffee

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9:00

Mechanisms of actions

• The range of payload types commercially
available and their mechanism of actions
• Payloads at the discovery or development
stages

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson, Project Manager, Femtogenix

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10:00

Morning Coffee

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10:15

Molecular modelling technique

• Molecular modeling approaches to
payload discovery
• Designing maximum cytotoxicity into
payloads

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson, Project Manager, Femtogenix

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11:15

Morning Coffee

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11:30

Design and engineering of payloads

• Engineering payloads to not release
prematurely
• Strategies to minimise the hydrophobicity
• Ensuring maximum resistance to
P-glycoprotein pumps in payload design

David E. Thurston, Professor of Drug Discovery, King's College London

Paul Jackson, Project Manager, Femtogenix

Paul Jackson, Project Manager, Femtogenix

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12:30

End of workshop

Holiday Inn Kensington Forum

97 Cromwell Road
London SW7 4DN
United Kingdom

Holiday Inn Kensington Forum

Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

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So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

HOTEL BOOKING FORM

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