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Cancer Vaccines

 

SAE Media Group present the 3rd Annual Cancer Vaccines Conference taking place in Central London on Monday 15th and Tuesday 16th September 2014.

This year's event will focus on the pre-clinical entities that are crucial when moving forward in clinical trials.   This will include, assessing antigen discovery and genome sequencing in addition to evaluating biomarkers and chimeric antigen receptors.

There is a growing demand for combination therapies and assessing clinical trial design, especially with failures in the clinic increasing, the question to be asked is how can we learn from this and move forward to ensure phase III developments and regulatory approval

The agenda will focus on in vivo targeting of antigens to dendritic cells for therapeutic anti-cancer vaccines, reviewing preventive vaccine novel adjuvants programmes aswell as evaluating patient stratification.

Furthermore, it will enable a broad range of academics, small biotechs and large pharmaceutical companies to review analytical methods to enable reliability upon standardisation of assays. In addition to assessing the modulation of the tumour microenvironment within early stages of their research and development.

FEATURED SPEAKERS

Alex Karlsson-Parra

Alex Karlsson-Parra

CSO, Immunicum AB
Birgit  Scheel

Birgit Scheel

Director Program Management Oncology, Curevac GmbH
Christian Ottensmeier

Christian Ottensmeier

Professor in Experimental Cancer Medicine, University Of Southampton
Emma King

Emma King

CRUK Senior Lecturer in Head and Neck Surgery , Southampton University
Harpreet  Singh

Harpreet Singh

Managing Director, Founder and CSO, Immatics Biotechnologies GmbH
John Beadle

John Beadle

Chief Executive Officer, Psioxus Therapeutics
Joseph  Melenhorst

Joseph Melenhorst

Director of the Product Development & Correlative Sciences laboratory, University Of Pennsylvania
Linda F. Powers

Linda F. Powers

CEO, Chairman of the Board, Northwest Biotherapeutics Inc
Madiha Derouazi

Madiha Derouazi

CEO , Amal Therapeutics
Tom Lillie

Tom Lillie

Therapeutic Area Head, Oncology, Amgen Ltd

Alex Karlsson-Parra

CSO, Immunicum AB
Alex Karlsson-Parra

Birgit Scheel

Director Program Management Oncology, Curevac GmbH
Birgit  Scheel

Christian Ottensmeier

Professor in Experimental Cancer Medicine, University Of Southampton
Christian Ottensmeier

Emma King

CRUK Senior Lecturer in Head and Neck Surgery , Southampton University
Emma King

Eric Leire

CEO, DanDrit Biotech
Eric Leire

Graham Pawelec

Professor of Experimental Immunology, University Of Tuebingen
Graham Pawelec

Harpreet Singh

Managing Director, Founder and CSO, Immatics Biotechnologies GmbH
Harpreet  Singh

John Beadle

Chief Executive Officer, Psioxus Therapeutics
John Beadle

John Maudsley

CEO, Cancer Vaccines Ltd
John Maudsley

Joseph Melenhorst

Director of the Product Development & Correlative Sciences laboratory, University Of Pennsylvania
Joseph  Melenhorst

Linda F. Powers

CEO, Chairman of the Board, Northwest Biotherapeutics Inc
Linda F. Powers

Lindy Durrant

Joint CEO, Scancell plc.
Lindy Durrant

Madiha Derouazi

CEO , Amal Therapeutics
Madiha Derouazi

Michael Hanna

CEO, Vaccinogen
Michael Hanna

Søren Jakobsen

Senior Scientist, Immudex
Søren Jakobsen

Tom Lillie

Therapeutic Area Head, Oncology, Amgen Ltd
Tom Lillie

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Assessing the impact in Antigen discovery for Cancer Vaccines

Michael Hanna

Michael Hanna, CEO, Vaccinogen

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10:00

Morning Coffee

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10:30

Reviewing the patient population selection ofr treatment

Michael Hanna

Michael Hanna, CEO, Vaccinogen

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11:30

Evaluating the in vivo/in vitro monitoring of the treatment and clinical endpoints

Michael Hanna

Michael Hanna, CEO, Vaccinogen

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12:30

Closing of workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Joseph  Melenhorst

Joseph Melenhorst , Director of the Product Development & Correlative Sciences laboratory, University Of Pennsylvania

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9:10

Therapeutic Vaccines for the treatment of Cancer - Where are we now?

Madiha Derouazi

Madiha Derouazi, CEO , Amal Therapeutics

  • Potential of protein based vaccines
  • Multi-epitopic immune response monitored in the periphery and at the tumor site
  • Persistent effector T cells
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    9:50

    T-VEC – Oncolytic immunotherapy in metastatic melanoma

    Tom Lillie

    Tom Lillie, Therapeutic Area Head, Oncology, Amgen Ltd

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    10:30

    Morning Coffee

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    11:00

    Case Study: Oncolytic Vaccines - A step into Cancer Immunotherapy

    John Beadle

    John Beadle, Chief Executive Officer, Psioxus Therapeutics

  • Reviewing the developments of Oncolytic vaccines for the treatment of cancer
  • Assessing vaccine delivery – clinical trial developments 
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    11:40

    T cell immune monitoring: reliability, standardisation and use in clinical trials

    Søren Jakobsen

    Søren Jakobsen, Senior Scientist, Immudex

  • Validity of assays for use in clinical trials
  • Data from proficiency panels
  • Advantages in cancer vaccines and cellular immunotherapies

     

  • clock

    12:20

    Networking Lunch

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    13:30

    Cancer Vaccination in the era of immunomodulatory immunotherapy

    Graham Pawelec

    Graham Pawelec, Professor of Experimental Immunology, University Of Tuebingen

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    14:10

    Activated allogenec DCs as an off-the-shelf vaccine adjuvant in Cancer Immunotherapy

    Alex Karlsson-Parra

    Alex Karlsson-Parra, CSO, Immunicum AB

  • Immunicum has developed a cellular adjuvant consisting of pre-activated  DCs producing high levels of DC-recruiting and DC-activating factors in a sustained fashion.
  • This concept doesn´t require MHC-compatibility between injected cells and the patient and therefore introduces the possibility of using pre-produced and freeze-stored DCs from healthy blood donors as an ”off-the-shelf” vaccine adjuvant.
  • Data from an ongoing phase I/II clinical trial indicate that intratumoral injection (thus using the patient´s own tumor as antigen source) of pre-activated allogeneic DCs is safe and induce a systemic CTL-mediated anti-tumor response that may prolong survival in patients  with metastatic renal cancer.
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    14:50

    Afternoon Tea

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    15:20

    Phase I/II trial of a novel antibody DNA immunotherapy, SCIB1 ImmunoBody which targets CD64, in the treatment of Melanoma

    Lindy Durrant

    Lindy Durrant, Joint CEO, Scancell plc.

  • We demonstrate that SCIB1 is safe
  • Of 25 patients, 23 received repeated immunisations of SCIB1 and 20 showed immune responses
  • Detection of objective clinical responses and overall survival times are encouraging
  • clock

    16:00

    Assessing the Developments in the field of Cancer Vaccines

    Eric Leire

    Eric Leire, CEO, DanDrit Biotech

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    16:40

    Chairman’s Closing Remarks and Close of Day One

    clock

    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Joseph  Melenhorst

    Joseph Melenhorst , Director of the Product Development & Correlative Sciences laboratory, University Of Pennsylvania

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    9:10

    A Perfect Partnership - A University of Pennsylvania and Novartis Collaboration!

    Joseph  Melenhorst

    Joseph Melenhorst , Director of the Product Development & Correlative Sciences laboratory, University Of Pennsylvania

    clock

    9:50

    RNActive® for cancer immunotherapy

    Birgit  Scheel

    Birgit Scheel, Director Program Management Oncology, Curevac GmbH

  • Targeting immunotherapy candidates for the treatment of cancer by harnessing the natural power of the immune system to fight disease
  • Current pivotal trials- updates and reviews of the current developments
  • clock

    10:30

    Morning Coffee

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    11:00

    High expectations and harnessing the body's immune system

    John Maudsley

    John Maudsley, CEO, Cancer Vaccines Ltd

  • Basis for and practical limits of immunotherapies
  • Pre-clinical models
  • Clinical progress in cell-based vaccines
  • clock

    11:40

    DCVax®-­Direct: A Novel Personalised Immune Therapy for Inoperable and Metastatic Solid Tumours

    Linda F. Powers

    Linda F. Powers, CEO, Chairman of the Board, Northwest Biotherapeutics Inc

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    12:20

    Networking Lunch

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    13:30

    What are the key questions in Cancer Immunotherapy

    Christian Ottensmeier

    Christian Ottensmeier, Professor in Experimental Cancer Medicine, University Of Southampton

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    14:10

    Head and neck cancer immunotherapy: translating laboratory science into a clinical program

    Emma King

    Emma King, CRUK Senior Lecturer in Head and Neck Surgery , Southampton University

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    14:50

    Biomarker-guided development of novel cancer vaccines- from off-the-shelf to actively personalised

    Harpreet  Singh

    Harpreet Singh, Managing Director, Founder and CSO, Immatics Biotechnologies GmbH

    clock

    15:30

    Afternoon Tea

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    16:00

    The Proactive issue of tumor genomic heterogeneity in Immunotherapy

    Michael Hanna

    Michael Hanna, CEO, Vaccinogen

  • The impact in Antigen discovery for Cancer Vaccines
  • Patient population selection for treatment
  • In vivo and in vitro monitoring of the treatment and clinical endpoints
  • Potential for development of epitope based vaccines for treatment and prevention
  • clock

    16:40

    Panel Discussion: Assessing Regulatory Approval and Clinical Trial Design

  • What are the implications of manufacturing?
  • What are the regulatory requirements from phase IIb to III?
  • Harpreet  Singh

    Harpreet Singh, Managing Director, Founder and CSO, Immatics Biotechnologies GmbH

    Michael Hanna

    Michael Hanna, CEO, Vaccinogen

    Christian Ottensmeier

    Christian Ottensmeier, Professor in Experimental Cancer Medicine, University Of Southampton

    John Maudsley

    John Maudsley, CEO, Cancer Vaccines Ltd

    clock

    17:20

    Chairman’s Closing Remarks and Close of Day Two


    CSO
    Immunicum AB
    Director of the Product Development & Correlative Sciences laboratory
    University Of Pennsylvania
    Joint CEO
    Scancell plc.
    Senior Scientist
    Immudex
    CEO
    Amal Therapeutics
    CEO
    Vaccinogen
    Therapeutic Area Head, Oncology
    Amgen Ltd
    CEO, Chairman of the Board
    Northwest Biotherapeutics Inc
    Director Program Management Oncology
    Curevac GmbH
    Professor in Experimental Cancer Medicine
    University Of Southampton
    CRUK Senior Lecturer in Head and Neck Surgery
    Southampton University
    CEO
    DanDrit Biotech
    Professor of Experimental Immunology
    University Of Tuebingen
    Managing Director, Founder and CSO
    Immatics Biotechnologies GmbH
    Chief Executive Officer
    Psioxus Therapeutics
    CEO
    Cancer Vaccines Ltd

    Sponsors and Exhibitors

    Supporters

    Workshops

    Tumour Genomic Heterogeneity in Immunotherapy

    Tumour Genomic Heterogeneity in Immunotherapy

    Holiday Inn Regents Park
    17 September 2014
    London, United Kingdom

    Snap Shot of Attendees at Cancer Vaccines 2014

    Download

    Interview with Dr Jos Melenhorst

    Download

    An Interview with Vaccinogen

    Download

    Sponsors and Exhibitors


    Cobra Biologics

    Sponsors and Exhibitors
    http://www.cobrabio.com

    Cobra Biologics is a leading international clinical and commercial manufacturer of biologics and pharmaceuticals with three GMP approved facilities. We offer a broad range of integrated and stand-alone development services, from cell line development to the supply of investigational medicinal products and commercial production. Our manufacturing solutions cover antibodies, recombinant proteins, viruses, phage, DNA, whole cell vaccines, small molecule API, lyophilisation and fill finish. Over 15 years of track record in producing biologics and pharmaceuticals for use in clinical trials has given our people a unique knowledge base as both manufacturer and also as service providers for the global market.


    Immudex

    Sponsors and Exhibitors
    http://www.immudex.com/

    Immudex provides MHC Dextramer reagents for quantification of antigen-specific T cells, and also provides MHC Multimer and Elispot immune monitoring proficiency panel services. The overall goal is to enable simple, accurate and reliable monitoring of antigen-specific cellular immunity, and to promote the routine use of these technologies in vaccine development.


    Northwest Biotherapeutics

    Sponsors and Exhibitors
    http://www.nwbio.com/

    "The Company (NWBio) has received some shareholder inquiries about whether the Company will be presenting at the SMi conference in London on September 27-28, 2017. While anticipating the disclosure of interim blinded data from NWBio’s Phase III trial of DCVax®-L for Glioblastoma, NWBio will not be presenting at this year’s SMi conference.”

    NWBio is developing DCVax® dendritic cell-based therapeutic vaccines. The Company’s DCVax®-L for resectable solid tumors is in a 331-patient Phase III trial for newly diagnosed GBM and Phase II trials in combination with checkpoint inhibitor drugs are planned. The Company’s DCVax®-Direct for inoperable solid tumors has completed a 40-patient Phase I trial for diverse cancers; various Phase II trials are planned.



    Scancell Ltd

    Sponsors and Exhibitors
    http://www.scancell.co.uk

    Scancell is an AIM listed company developing novel treatments for cancer based on its proprietary ImmunoBody® and Moditope® technology platforms which stimulate target specific high avidity T cells. Scancell’s first ImmunoBody®, SCIB1, which is being developed for melanoma, has produced a potent immune response and tumour destruction in late stage patients.

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    Antibodies Online

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    PMR

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    Cancer Biomarkers (CBM)

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    Absave

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    Pharmalicensing

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    British Pharmacological Society

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    Infectious Agents and Cancer

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    Journal for ImmunoTherapy of Cancer

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    Pharmaceutical Technology

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    http://www.benthamscience.com/

    Bentham Science Publishers is a major STM journal publisher of 130 plus print and online journal. Out of these, 40 journals have already registered good IMPACT FACTORS as per Journal Citation Reports® 2017. These titles have extensive readership mostly in Europe and North America. For a detailed profile please visit our website at http://www.benthamscience.com. Besides, Bentham Science publishes eBooks in all areas of Science, Technology and Medicine. Our eBooks provide professionals, academicians, corporate researchers, graduates and undergraduates worldwide with the most current information in their subject areas of interest. Our eBooks are also available in the ePub and Kindle formats besides the PDF edition here http://ebooks.benthamscience.com/. Bentham is offering attendees of this conference discounts on its publication. For more information click here


    Swiss Biotech Association

    Supporters
    http://www.swissbiotech.org/

    The Swiss Biotech Association (SBA) is the national industry association for biotechnology, including pharmaceuticals, diagnostics, agriculture, food, cosmetics, environmental biotechnology, and specialty chemicals. Members are companies active in modern biotechnology, such as R&D, Production, Marketing and Sales, Finance, Services and Consulting. SBA provides a networking platform for Life Science clusters, academic and federal institutions the like. Founded in March 1998, the Association grows steadily.

    Holiday Inn Regents Park

    Carburton Street
    London W1W 5EE
    United Kingdom

    Holiday Inn Regents Park

    Choose the well-connected Holiday Inn London-Regent's Park hotel, with a superb central London location and speedy transport links. Holiday Inn London-Regent's Park is in a leafy and cosmopolitan area of central London, a 10-minute walk from bustling Oxford Street. Leave your car in our NCP managed underground car park, and explore London by Tube. Great Portland Street Tube station is 25 metres from the hotel, from where you can reach the City and Canary Wharf in 30 minutes, and London Heathrow Airport in 45 minutes.

    Wireless Internet is available throughout the hotel, and you can invite up to 300 people to events at the Academy Conference Centre, with an IT technician and break-out zones. Holiday Inn London-Regent's Park is a 10-minute walk from Santander's offices and businesses in the BT Tower. Stroll 5 minutes to Regent's Park, where you'll find London Zoo and pretty Primrose Hill. We're a 10-minute walk from Bond Street boutiques and 20 minutes from Buckingham Palace and cruises on the River Thames.

    Ask our Concierge to plan your day out and book West End theatre tickets. Room Service is available 24 hours at Holiday Inn London-Regent's Park, or dine in the vibrant Junction Restaurant. Our Junction Bar has a menu of light bites, and a hot breakfast buffet is served daily.

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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