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From Genes to Drugs : Integrating Genomics, Proteomics and Bioinformatics
3 April - 4 April 2000
From Genes to Drugs : Integrating Genomics, Proteomics and Bioinformatics
The plethora of genomic information now in the public domain has to be sifted through and analysed if the perceived value of this data in the discovery of new therapeutics is to be realised. The functions of the genes and how they are implicated in disease pathways has to be elucidated further. Functional genomics, proteomics and bioinformatics are being employed in this endeavour, the most successful companies are the ones which effectively integrate these technologies in order to obtain maximal value from the data.

This conference brings together the leaders in the new technology arena from both the biotechnology industry and the pharmaceutical industry. It will demonstrate how the leaders in the biotechnology market are utilising data to produce therapeutic targets and the drugs of tomorrow. It draws upon case studies to demonstrate effective methods to integrate new technologies in order to speed up the pace of therapeutic discovery and development.

Companies attending SAE Media Group pharmaceutical events include:
3M Healthcare Pharmaceuticals - Abbott Laboratories - Amgen - AstraZeneca - Baxter Healthcare – Bayer - Boehringer Ingelheim - Bristol-Myers Squibb - Eli Lilly - GlaxoWellcome - Hoffmann-La Roche - Janssen-Cilag - Johnson & Johnson - Knoll AG – Lederle - Merck Sharp & Dohme - Novartis - Novo Nordisk Pharmaceuticals - Parke-Davis - Pasteur Merieux MSD Ltd - Pharmacia & Upjohn - Pfizer Corporation - RhÔne-Poulenc Rorer - Proctor & Gamble - Schering-Plough - SAE Media Groupth & Nephew - SAE Media GroupthKline Beecham – Synthelabo - Warner Lambert - Wyeth Ayerst

Conference agenda

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8:30

Registration & Coffee

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9:00

Introduction to collaborating in the biotechnology industry

  • The importance of collaborative agreements within the biotechnology industry
  • Increased financing
  • Shared risk when working with new technologies
  • Who are the players in the biotechnology industry?
  • Managing the collaboration: effective communication
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    9:30

    What kind of partnership is best for you?

  • Licensing out products following pre-clinical development
  • Identifying the correct product to license in
  • Gaining or giving access to technologies
  • Deciding which route to take: comparison of different agreements
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    10:30

    Case studies demonstrating types of collaborative agreements and the advantages and disadvantages of each

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    11:00

    Morning coffee

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    11:15

    Issues in IPR following collaborations

  • Joint ownership issues
  • Who is responsible for establishing and defending IPR?
  • Ensuring the best deal in royalty payments
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    12:00

    Potential problem areas and how to avoid them

  • Failure to meet milestone targets
  • Establishing effective two way communication
  • Solving disputes: arbitration
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    12:45

    Discussion and questions - review of the session

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    13:00

    Close of workshop

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Dr Neil MacKenzie

    Dr Neil MacKenzie, Business Development Director, Oxford Biomedica

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    9:10

    FROM GENES TO DRUGS

    Dr Mark Swindells

    Dr Mark Swindells, Chief Scientific Officer, Inpharmatica

  • The human genome cloned: what will come next?
  • The potential of determining function and role of the genes
  • Identification of potential therapeutic targets
  • Impact of genomic data on pharmaceutical research to date
  • The future for the biotech and pharmaceutical industry
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    9:40

    BOTTLENECKS IN DRUG DISCOVERY AND DEVELOPMENT

    Dr Patrick Kleyn

    Dr Patrick Kleyn, Chief Scientific Officer, Gemini Research

  • Using accelerated positional cloning to identify large numbers of potential targets
  • Validating genetic targets with human clinical information
  • Identifying factors in common, complex, age-related illnesses
  • Success of genomics strategies to date
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    10:20

    THE USE OF FUNCTIONAL GENOMICS AS A RESEARCH TOOL

    Dr Hartmut Voss

    Dr Hartmut Voss, Vice President Genomics, LION Biosciences

  • Identify the genes: what next?
  • What can functional genomics achieve?
  • Technologies used in the functional genomics arena
  • Success of functional genomics strategies to date
  • The role for functional genomics within the framework of traditional research approaches
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    11:00

    Morning coffee

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    11:20

    GENE EXPRESSION PROFILING

    Dr Edward Zanders

    Dr Edward Zanders, Senior Scientist, GlaxoWellcome

  • The value of applying genomic technologies to auto-immune research
  • Methods to monitor inflammatory processes using gene expression profiling
  • Drug discovery and gene expression profiling in rheumatoid arthritis
  • Future directions for GlaxoWellcome and gene expression profiling
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    12:00

    SPEEDING UP TOXICITY TESTING

    Dr Jan Mous

    Dr Jan Mous, Global Head of Genomic Technology, Hoffmann-La Roche

  • The technology platform at Hoffmann-La Roche
  • Development of microarray technology
  • How can microarrays be used in toxicity testing?
  • Results to date: how are microarrays impacting on the speed and sensitivity of toxicity testing?
  • Expense vs speed: do microarrays pay their way?
  • Future development and potential for microarray technology
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    12:40

    Lunch

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    14:00

    FROM GENOMICS TO THERAPEUTICS

    Dr Kevin Pritchard

    Dr Kevin Pritchard, Head of Protein Chemistry, Cambridge Antibody Technology

  • Industrialised phage antibody technology
  • Human monoclonal antibodies: opportunities in functional genomics
  • The ProAb programme: phage antibodies as specific molecular probes
  • Cont1nuity™ Bioinformatics - image based data mining
  • Human monoclonal antibodies in the clinic
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    14:40

    INTEGRATING PROTEOMICS AND GENOMICS

    Dr Mark Egerton

    Dr Mark Egerton, Vice President, Incyte

  • Progress in integrating RNA and protein expression technologies
  • Methodologies for comparing RNA and protein expression data content
  • How will expression data contribute to our understanding of disease processes?
  • How can expression studies impact on toxicological studies?
  • Developing the technology: what does the future hold?
  • Combining necessary skills through partnership
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    15:20

    Afternoon Tea

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    15:40

    HUMAN PHENOMICS IN DRUG DISCOVERY

    Dr Alastair Riddell

    Dr Alastair Riddell, Chief Executive Officer, Pharmagene

  • Using phenomics to elucidate disease mechanisms
  • Integrating human genomics, proteomics and pharmacology into biological mechanisms
  • Converting knowledge of mechanism into useful targets for drug intervention
  • Targets identified to date
  • The value of human pre-clinical testing
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    16:20

    TECHNOLOGY TRANSFER IN BIOTECHNOLOGY

    Dr George Rahim

    Dr George Rahim, Technical Manager, MMI

  • Examining the technological needs of your organisation
  • Finding the right technology to develop your business
  • Establishing the best route to obtain the technology: licensing and partnerships
  • Business Incubation
  • Intellectual property right issues in technology transfer
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    17:00

    Chairman’s Closing Remarks and Close of Day One

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    17:10

    Drinks Reception

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    8:30

    Re-registration and Coffee

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    9:00

    Chairman's Opening Remarks

    Dr Richard Judson

    Dr Richard Judson, Chief Executive Officer, Gennaissance

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    9:10

    PHARMACOGENOMICS AND CLINICAL TRIALS

    Dr Fred Ledley

    Dr Fred Ledley, Principle Scientific Advisor, Variagenics

  • Impact of pharmacogenomics on the cost of drug development and clinical trials
  • Potential value of pharmacogenomics in clinical trials
  • Is it possible to incorporate pharmacogenomics into clinical trials?
  • Scaling down the complexity of the problems addressed in clinical trial
  • Haplotype vs SNP association studies
  • The need for new technologies in pharmacogenomics
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    9:40

    GENOTYPING IN ALZHEIMER’S DISEASE

    Dr Larry Altstiel

    Dr Larry Altstiel, Group Leader Neurodegenerative Disorders, Eli Lilly

  • The role of the ApoE4 allele in late-onset familial Alzheimer’s disease
  • Methodology employed in the Xanomeline trial
  • Effect of integrating pharmacogenomics on trial length and costs
  • Overall study results
  • The future for pharmacogenomics at Eli Lilly
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    10:20

    IMPROVING THE ACCESSIBILITY OF BIOINFORMATICS

    Eli Mintz

    Eli Mintz, President, Compugen

  • The multitude of genomic databases
  • Uses of bioinformatics
  • Is bioinformatics being used effectively in drug discovery and development?
  • Development of user friendly software: user requirements
  • Providing the right tools with the right training
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    11:00

    Morning Coffee

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    11:20

    EFFECTIVE USE OF BIOINFORMATICS

    Christophe Person

    Christophe Person, Vice President of Informatics, Lexicon Genetics

  • High-throughput analysis of public and proprietary databases
  • Using bioinformatics to identify the most promising targets
  • Gene Trapping and Genomic Databases
  • Effective use of Medline in data mining
  • Targets identified at Lexicon
  • Lexgen.com: Using the Internet for drug discovery in the post-genome area
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    12:00

    INTEGRATING DISCOVERY INFORMATICS

    Manuel Glynias

    Manuel Glynias, President & Chief Executive Officer, NetGenics

  • The value of an integration strategy
  • Two aspects to integration: technical & domain
  • Technical integration through a Component Framework
  • Future support for evolutionary change and incremental growth
  • Domain integration example
  • Proposed solutions: which approach is best?
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    12:40

    Lunch

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    14:00

    DATAMINING TO IDENTIFY NOVEL TARGETS

    Dr Michael Jackson

    Dr Michael Jackson, Senior Director, The R. W. Johnson Pharmaceutical Research Institute

  • Overview of the technology at Johnson & Johnson
  • Global sequence mining and identification of ‘best bet target families’
  • Applying microarray technology to filter out genes of interest
  • Laser capture microdissection: direct comparison of gene expression patterns in diseased vs normal cells
  • Extrapolating gene expression data to pathways of interest: global datamining
  • Targets of interest identified to date
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    14:40

    BIOINFORMATICS AND DEVELOPMENT OF PROTEIN THERAPEUTICS

    Dr Henrik Vissing

    Dr Henrik Vissing, Head of Bioinformatics & Genomics, Novo Nordisk

  • The value of developing therapeutic proteins
  • Using bioinformatics to discover therapeutic protein targets
  • The importance of good genomic and proteomic databases for effective use of bioinformatics
  • Is there a role for bioinformatics in therapeutic protein development?
  • The future of therapeutic protein development: new therapeutic areas to target
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    15:20

    Afternoon Tea

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    15:40

    IDENTIFICATION OF NEW ANTI-FUNGALS

    Dr Richard Wobbe

    Dr Richard Wobbe, Senior Director Drug Discovery, Scriptgen

  • Target selection criteria for anti-fungals
  • Identification of potential gene targets: effective bioinformatics
  • GATE technology: target validation and the elucidation of gene function
  • Targets identified to date
  • A generalized high-throughput screening approach for dealing with newly identified targets, even those of unknown function
  • Application of target validation technologies to drug mechanism of action studies
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    16:20

    IDENTIFICATION OF LEAD COMPOUNDS

    Dr Mark Brann

    Dr Mark Brann, President & Chief Scientific Officer, ACADIA Pharmaceuticals

  • Using genomics to identify selective compounds
  • Methodology employed in screening compounds against the M1 receptor genes
  • Involvement of the M1 receptor in Alzheimer’s disease and desirability of selective M1 ligands
  • Number and type of leads produced using this method
  • Progress to date: have these leads followed through?
  • Is the use of more selective compounds the answer for Alzheimer’s disease therapeutics?
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    17:00

    Chairman's Closing Remarks and Close of Conference

    Workshops

    The Hatton, at etc. venues

    51/53 Hatton Garden
    London EC1N 8HN
    United Kingdom

    The Hatton, at etc. venues

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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