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SAE Media Group proudly present their 2nd Annual conference on Peptides taking place on 8th & 9th July 2015 in London. The conference sets the stage for attendees to gain valuable insight into innovative topics such as Cyclic Peptides: R&D platforms, manufacture and stability, Oral Delivery of peptides, Cell permeable peptide therapeutics for cancer treatments and Development of Peptides for the Clinic. Along with this, the program will provide insight into Formulating Solutions for Delivery and round table discussions on case studies demonstrating the translation of R&D peptides to the clinic.

This years event will allow delegates to get a unique insight into the field and the developments that have been made. Keynote talks from Lutz  Jermutus Senior Director of  R&D at Medimmune, Dan Teufel  CSO at Bicycle Therapeutics and Jorg Vollmer CEO at Nexigen will allow for a greater understanding of breakthrough peptide therapeutics and the platforms behind them.

The peptides market is currently worth $14.1Bn and is growing at an average CAGR of 8.7%. The market is forcasted to grow to $25.5Bn at the end of 2018. The market will grow due to the explosion of non communicable diseases such as metabolic and cardiovascular diseases that that have become endemic in our society.

Peptide technology has been growing at an impressive rate with enhancements in synthesis mechanisms such as solid and liquid phase synthesis. By attending this event you will gain a greater understanding of the techniques used and what systems to implement.

There has also been an impressive growth in the cancer peptide market with a CAGR of  9.4%. Ground breaking "first in class drugs" will be presented to the delegation with key presentations being made on novel VEGF inhibitor drugs and mechanisms of delivering drugs intercellularly.

Orally available drugs are also a key constituent of the meeting with multiple talks providing an explanation to where we currently are in the field and what breakthrough technologies have been developed. A key  talk will be provided by Roger New of  Proxima concepts on a new orally available insulin delivery platform.

Currently the peptide market makes up only 1.55% of the overall market, but this is expected to change thanks to new technologies and the increased number of peptides in the pipeline with 120 in the clinical trial phase and 600 in the preclinical stage.


 

Keynote Speakers Include:

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune
Jörg vollmer, CEO, Nexigen
Stephen Hale, SVP Biological Sciences, Ensemble Therapeutics
Dan Teufel
, Head of Chemistry, Bicycle Therapeutics
Juan J. diaz-Mochon
, Group Leader, Pfizer (GENYO)

 

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Conference agenda

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13:30

Registration and coffee

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14:00

Overview of current cyclic peptides employed in a therapeutic capacity

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14:20

Why cyclic peptides? Advantages over other approaches. Summary of players in field. Manufacturing and Regulation

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15:00

Coffee Break

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15:30

Discovery methodologies

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16:15

Concrete applications

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17:00

Discussion

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17:45

Close

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune

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9:10

Past, present and future of Peptide Platforms: Challenges and Opportunities

Dan Teufel

Dan Teufel, Head of Chemsitry, Bicycle Therapeutics Limited

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9:50

Peptide-nanoconjugates: applications in biomedicine

Rosario Sanchez-Martin, Group Leader of NANOCHEMBIO research team , GENYO

• Peptide conjugation techniques, an introduction.
• Peptide drug conjugation to nanoparticles, a multifunctional approach
• Peptide based Intracellular nanosensors
• Peptide based selective delivery nanodevices
 

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10:30

Morning Coffee

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11:00

Libraries of DNA encoded peptidic macrocycles for drug discovery

Stephen Hale, Senior Vice President, Biological Sciences, Ensemble Therapeutics

• Large libraries of synthetically-accessible peptidic macrocycles facilitate hit identification
• Interrogating encoded libraries is a rapid and massively parallel process
• Practical applications of Ensemble’s discovery platform
 

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11:40

Peptide aggregation: Mechanism, challenges on cycle life development and analytical tools

Anna-Karin  Lundback

Anna-Karin Lundback, Scientist I, MedImmune

• Understanding aggregation pathways
• Tools to study physical degradation
• Selecting the best candidate for development
 

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12:20

Networking Lunch

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13:30

Peptide Nucleic Acids as encoding and diagnostic tools

Juan J Diaz-Mochon, Ramon y Cajal Fellow , GENYO

• PNA encoded peptide libraries - cell based assays Peptide drug conjugation to nanoparticles, a multifunctional approach
• Dynamic Chemistry for enzyme-free nucleic acid testing for diagnostic applications. SMART Nucleobases and modified PNAs.
• SNP Genotyping by Dynamic Chemistry and MALDI-Tof
 

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14:10

ROUND TABLE DISCUSSION:Translating peptide R&D to the clinic

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune

·          An invaluable round table session allowing for business development

·          Session introducing case studies into how individuals upscale production

·          Challenges faced in transferring R&D from the bench to clinic and how these problems were solved

 

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14:50

Afternoon Tea

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15:20

Genetic selection of cyclic peptide inhibitors of protein-protein interactions

Ali Tavassoli, Reader in Chemical Biology, University Of Southampton

• Cyclic peptide libraries of around a hundred million members are readily prepared with SICLOPPS
• The activity of each peptide is measured against a given protein-protein interaction using a reverse two-hybrid system
• This plug and play platform has yielded several first in class inhibitors
 

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16:00

Using structural biology in the design, production and study of cancer targeting peptides

Mark Howard, Reader in Biological NMR Spectroscopy, University Of Kent

• Synthetic and recombinant peptides designed by structural analysis
• NMR spectroscopy used to confirm structure and receptor specificity
• Disulphide bond cyclisation can create changes in peptide specificity
 

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16:40

Chairman’s Closing Remarks and Close of Day One

Lutz Jermutus, Senior Director, R&D & Product Development Team Leader, MedImmune

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Alexandra Matzke-Ogi

Alexandra Matzke-Ogi, CSO, Amcure

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9:10

A novel class of peptide coagulant for surgical bleeding

Renata Zbozien, Research Manager, Haemostatix Ltd

• Designing against multiple criteria
• SAR optimisation
• Formulation
 

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9:50

Delivery of peptides via the oral route

·          Overcoming the intestinal barrier

·          Oral insulin

·          Delivery to liver

 

Roger New, Co-founder & CSO, Proxima Concepts Ltd

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10:30

Morning Coffee

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11:00

Biological insights into therapeutic peptide modification: The development of stapled peptides to modulate BRCA2-RAD51 interaction

Chiara Valenzano, Principal Scientist, UCB Celltech

  • Chemicals strategies to improve peptides biological activity  and  overcome the intrinsic limitations of peptides as chemical tool and therapeutic agents, will be described
  • Case study: investigation of BRCA2-RAD51 protein-protein interaction, as an example of stapled peptides that succeeded  where a small molecules approach  failed.
     
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    11:40

    Metallohelix peptidomimetics – a new area of chemical space

    Peter Scott, Professor of Chemistry, University of Warwick

    • Up to now, helical metal (e.g. Fe) complexes have been insoluble, unstable, unfunctionalised, highly symmetrical and racemic.
    • We have addressed all these problems to create self-assembling architectures on a realistic scale that appear to behave like short amphipathic helices.
    • There is high structure dependent activity in cancer and antimicrobial screens, and apparently low toxicity.

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    12:20

    Networking Lunch

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    13:30

    Antimicrobial peptides and gene-delivery peptides

    James Mason , Senior Lecturer, Kings College London

    •          Gaining a new tool to improve therapeutic attributes of therapeutic proteins
    •          Recent advances in the field of antimicrobial peptides
    •          Structural functional relationships between modifications and therapeutics
     

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    14:10

    Development of a first-in-class drug candidate for the treatment of metastatic cancer

    Alexandra Matzke-Ogi

    Alexandra Matzke-Ogi, CSO, Amcure

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    14:50

    Afternoon Tea

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    15:20

    Drugging the Undruggables - Cell-permeable peptide inhibitors of cancer stem cell-relevant signalling pathways

    Joerg Vollmer

    Joerg Vollmer, CEO, Nexigen GmbH

    • Tumor recurrence and spread caused by cancer stem cells are one of the challenges in today’s treatment of cancer
    • Cell-permeable peptide therapeutics targeting protein-protein interactions are an attractive alternative to conventional therapies to inactivate intracellular cancer-relevant signaling pathways
    • Nexigen’s NexiTides target such pathways, have strong in vitro anti-cancer stemness activity and are effective in models of tumor growth and metastases
     

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    16:00

    Advances in oral peptide delivery

    David Brayden, Professor of advanced drug delivery, University College Dublin

    • Selected analyses of technologies that have reached clinical
    • Addressing mechanisms of action of intestinal permeation enhancer-based systems
    • Toxicology issues of permeation enhancers:  perceived or real?
     

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    16:40

    Chairman’s Closing Remarks and Close of Day Two

    Alexandra Matzke-Ogi

    Alexandra Matzke-Ogi, CSO, Amcure

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    Bachem provides comprehensive services to the pharma and biotech industries. It specializes in the development of innovative, efficient manufacturing processes and the reliable production of peptide-based APIs. The group has a global reach with more experience and know-how than any other company in the industry. Bachem. Pioneering Partner for Peptides


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    The PolyPeptide Group is a world leading peptide drug substance manufacturer with six manufacturing facilities distributed over 5 countries and 3 continents (Belgium, France, India, Sweden, USA). Our exclusive focus on peptides for pre-clinical, clinical and commercial use provides our customers with the highest quality products and services that exceed expectations.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

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