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Biobanking

Access to samples is paramount to scientific research. DNA, RNA, proteins, cells and tissues of all types are being stored centrally for later use in experiments conducted by academia and industry alike. This has given rise to the concept of Biobanking, which in 2009 was described by Time Magazine as one of the ’10 Ideas Changing the World Right Now’.

 

Although not an entirely new conception, there is significant change driving current development. With greater impetus being put on data sharing, interoperability and harmonisation of biobanks, single centre research facilities are evolving into research infrastructures. Considering that sharing, storing and using biosamples can vary wildly in cost, social and scientific impact there are efforts now being made to associate value to existing biological resources.
 

Comments from last years delegates included:

'Well planned, great venue, good range of attendees'
'Very Informative; I wish I had attended years ago'
 

FEATURED SPEAKERS

Amir Gander

Amir Gander

Senoir Knowledge Transfer Associate, UCL Medical School Royal Free Campus
George   Tokiwa

George Tokiwa

Associate Scientific Director, Merck Research Laboratories
Pablo Arrisi

Pablo Arrisi

Biosample Operations Manager, Roche Products
Paul Whittaker

Paul Whittaker

Direstor and Unit Head for Pre-Clinical Biomarkers, Respiratory Disease Area, Novartis

Amir Gander

Senoir Knowledge Transfer Associate, UCL Medical School Royal Free Campus
Amir Gander

Anders Brinne

Biobank Informatics Manager, Karolinska Institutet
Anders  Brinne

Ann Cooreman

Chief operating officer, Tissue Solutions
Ann Cooreman

Balwir Matharoo-Ball

Operations Manager Trasitional Research & Biobanking, Nottingham University Hospital NHS Trust
Balwir Matharoo-Ball

Brian Thompson

Director of R&D, Nottingham University Hospital NHS Trust
Brian Thompson

Celine Lewis

Public Engagement Lead STRATUM, Genetic Alliance
Celine  Lewis

Daniel Cooper

Partner , Covington & Burling Llp
Daniel Cooper

George Tokiwa

Associate Scientific Director, Merck Research Laboratories
George   Tokiwa

Geraldine Thomas

Chair in Molecular Pathology, Chernobyl Tissue Bank
Geraldine Thomas

Helen Moore

Director of Biospecimen Research Network (BRN), Office of Biorepositories and Biospecimen Research (OBBR), National Cancer Institute
Helen Moore

Hemal Rajani

Technical Project Manager, Labvantage Solutions
Hemal Rajani

Jens Mattsson

CEO, Lifegene Project
Jens  Mattsson

John Cason

Director of the Infectious Diseases BioBank, Kings College London
John Cason

Julie Corfield

Director, Areteva
Julie Corfield

Katherine Littler

Policy Adviser, Welcome Trust
Katherine Littler

Kirstin Goldring

Biobank Facilitator, University College London
Kirstin Goldring

Kristian Hveem

Head of HUNT Biobank, Leader Biobank Norway, Norwegian University Of Science And Technology
Kristian  Hveem

Kristof Van Quathem

Associate , Covington & Burling Llp
Kristof Van Quathem

Mads Roepke

Scientist, Leo Pharma
Mads Roepke

Man H Zawati

Lawyer and Academic Associate , McGill University Department of Human Genetics
Man H Zawati

Martin Yuille

Joint Director, Centre for Integrated Genomic Medical Research, University of Manchester
Martin Yuille

Martyn Foster

Independent Consultant in Experimental Pathology, Independent Consultancy
Martyn Foster

Neil Formstone

Lay Member, NIHR Biomedical Research Centre
Neil Formstone

Pablo Arrisi

Biosample Operations Manager, Roche Products
Pablo Arrisi

Paul Hofman

Head of Human Biobank Unit, Pasteur Hopital, University of Nice
Paul Hofman

Paul Whittaker

Direstor and Unit Head for Pre-Clinical Biomarkers, Respiratory Disease Area, Novartis
Paul Whittaker

Pete Jackson

MD, ELPRO UK
Pete Jackson

Raymond Dalgleish

Senior Lecturer, University of Leicester
Raymond Dalgleish

Conference agenda

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8:30

Registration & Coffee

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9:00

Introductions and workshop overview

  • Introduction to the LabVantage Biobanking LIMS
  • Overview of the typical implementation areas
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    9:10

    Organisational requirements and implementation methodologies

  • What are the key drivers for an organisation to implement a new Biobank LIMS
  • Different methodologies to implement a ‘Live’ system
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    9:40

    Master data, regulatory requirements, timelines and budget

  • Regulatory requirements in capturing data, how to audit the records and access them readily              
  • Time, Costs and Benefits of implementation without risking the quality
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    10:20

    End-user ‘Buy In’ and maintaining and best practices of a biobanking LIMS

  • Importance of end users involvement both on system design and best practices
  • Typical Biobanking functional areas, covered by the LABVANTAGE product
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    11:00

    Coffee Break

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    11:30

    Systems design – Whom is this system going to benefit? A cost benefit analysis

  • Which parts of the organisation the system will benefit
  • The benefits of a fully operational system
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    12:20

    Closing analysis

  • Examples of current implementations around the world
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    12:30

    Close of workshop

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    13:30

    Registration & Coffee

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    14:00

    Introductions and workshop overview

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    14:15

    Definition and discussion of virtual Biobanking: what is it? How does it work?

  • What counts as a virtual biobank and what doesn’t?
  • Group discussion of what virtual biobanking is, examples of virtual biobanks?
  • Examples of existing virtual biobanks and how they work, assessment of their effectiveness
  • Comparison of virtual and physical biobanks as an exercise
  • clock

    14:45

    Practical exercise: Pros and Cons of virtual Biobanking

  • Perspective of client (biotech, pharma, CRO)
  • Perspective of source
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    15:25

    Coffee Break

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    15:45

    Best working practices (national and international)

  • Are there guidelines for virtual biobanking?
  • What should they be?
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    16:15

    Ethics and governance

    • UK Human Tissue Authority guidelines
    • Ethics in the UK and other countries, how does it fit?
    • Oversight of virtual biobanks
    • Oversight of commercial and non-commercial biobanks

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    17:00

    General Discussion Round & Close

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    17:30

    Close of Workshop

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Julie Corfield

    Julie Corfield, Director, Areteva

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    9:10

    Next generation biobanking: rise of the networks

    Martin Yuille

    Martin Yuille, Joint Director, Centre for Integrated Genomic Medical Research, University of Manchester

  • Primary biobanks and secondary biobanks
  • Networked biobanks and networked biobanking
  • The emergence of the science of biobanking
  • clock

    9:50

    The road to harmonization of biospecimen practices in the U.S. and internationally

    Helen Moore

    Helen Moore, Director of Biospecimen Research Network (BRN), Office of Biorepositories and Biospecimen Research (OBBR), National Cancer Institute

  • Ethical, legal, scientific, IT, and operational challenges to harmonization
  • The NCI Best Practices for Biospecimen Resources
  • Biospecimen Science research programs in the U.S. and Europe
  • Building evidence-based Best Practices
  • Acquisition of normal tissues for genomic research
  • clock

    10:30

    Morning Coffee

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    10:50

    Challenges facing new biobanks and building sustainability

    Geraldine Thomas

    Geraldine Thomas, Chair in Molecular Pathology, Chernobyl Tissue Bank

  • Sample acquisition strategies
  • Appealing to donation candidates
  • Methods for sample storage
  • Cost recovery, why the taboo?
  • clock

    11:30

    Coordinating national biobanking projects

    Kristian  Hveem

    Kristian Hveem, Head of HUNT Biobank, Leader Biobank Norway, Norwegian University Of Science And Technology

  • The role of genetic factors, environmental exposures and lifestyle in major diseases of late and middle age
  • Collecting extensive data and biological samples
  • The relationship between how samples are processed and scientific usefulness
  • Sample handling and storage protocol
  • clock

    12:10

    Panel discussion: ‘How can biobanking be made more cost effective?’

  • Cost recovery, what can be done?
  • Managerial issues
  • Budgeting and financial strategy
  • Public sector services and reflective reimbursement
  • Pablo Arrisi

    Pablo Arrisi, Biosample Operations Manager, Roche Products

    Geraldine Thomas

    Geraldine Thomas, Chair in Molecular Pathology, Chernobyl Tissue Bank

    Martin Yuille

    Martin Yuille, Joint Director, Centre for Integrated Genomic Medical Research, University of Manchester

    George   Tokiwa

    George Tokiwa, Associate Scientific Director, Merck Research Laboratories

    Paul Hofman

    Paul Hofman, Head of Human Biobank Unit, Pasteur Hopital, University of Nice

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    12:50

    Networking Lunch

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    13:50

    The Proposed EU Data Protection Regulation - Impact on Biobanks

    Kristof Van Quathem

    Kristof Van Quathem, Associate , Covington & Burling Llp

  • New features of European Commission proposed regulation replacing national data protection laws such as the data protection act
  • New features including breach notification obligation, explicit reearch exemption and new rules on international transfers and applicable law.
  • How will the proposed regulation impact the use of personal data stored and shared in Biobanks - Will ICFs have to be modified and in what respect?
  • Secondary use of samples and associated data, and impact of key-coding personal data under the new regime.
  • clock

    14:30

    The Roche clinical repository - key enabler to personalized healthcare

    Pablo Arrisi

    Pablo Arrisi, Biosample Operations Manager, Roche Products

  • PHC and Biomarkers
  • Operations behind biosampling in clinical trials
  • RCR: the facility and associated processes
  • clock

    15:10

    Building a large-scale biobank for Sweden

    Anders  Brinne

    Anders Brinne, Biobank Informatics Manager, Karolinska Institutet

  • Supporting large-scale prospective sample- and data collection 
  • Local vs central sample management
  • Making use of healthcare infrastructure
  • Securing personal integrity
  • clock

    15:50

    Afternoon Tea

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    16:10

    Quality control of biological samples

    John Cason

    John Cason, Director of the Infectious Diseases BioBank, Kings College London

  • Sample handling and storage protocol
  • Preservation techniques
  • Temperature monitoring, stabilisation and validation
  • clock

    16:30

    Environmental monitoring Biobanking facilities

    Pete Jackson

    Pete Jackson, MD, ELPRO UK

  • Why do we need to monitor
  • Where do we need to monitor - location, position and quality of sensors
  • What needs to be monitored
  • Specific challenges within a biobank
  • Keep the overview - Optimise your processes
  • Requirements of a monitoring system
  • Typical project handling
  • Building in security
  • Approaches for automating the handling of data
  • Approaches for maintaining the system with minimal disruption
  • Validation
  • clock

    17:10

    Quality assurance and integrated biosample processing management

    George   Tokiwa

    George Tokiwa, Associate Scientific Director, Merck Research Laboratories

  • Quality control, is there any point without quality assurance?
  • Considerations for managing the planning, collection and processing of clinical specimens
  • Methods to ensure quality from protocol drafting to specimen disposition
  • Considerations for metrics
  • clock

    17:50

    Technologies for managing biobanks with a focus on Radio Frequency Identification (RFID)

    Paul Hofman

    Paul Hofman, Head of Human Biobank Unit, Pasteur Hopital, University of Nice

  • Advantages of RFID based systems
  • Improving traceability and security
  • Tracking from bank to lab
  • clock

    18:30

    Chairman’s Closing Remarks and Close of Day One

    Julie Corfield

    Julie Corfield, Director, Areteva

    clock

    8:30

    Registration & Coffee

    clock

    9:00

    Chairman's Opening Remarks

    Julie Corfield

    Julie Corfield, Director, Areteva

    clock

    9:10

    Strategic Tissue Repository Alliances Through Unified Methods (STRATUM)

    Julie Corfield

    Julie Corfield, Director, Areteva

  • The foundation for a biobanking infrastructure in the UK
  • What it aims to achieve and why; including
  • Biobanking Policy
  • Technical Standards and Sample Life Cycle Management
  • Optimising access to and use of samples
  • clock

    9:45

    “For the Times they are A-Changin’”: Assessing the Ethical and Legal Issues of Biobank Closure

    Man H Zawati

    Man H Zawati , Lawyer and Academic Associate , McGill University Department of Human Genetics

  • Associated ethical issues with sample reallocation
  • Gaining consent for closure plans
  • Maximising use while maintaining trust
  • clock

    10:20

    Morning Coffee

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    10:50

    Informed vs. standardised consent the ethical implications

    Balwir Matharoo-Ball

    Balwir Matharoo-Ball, Operations Manager Trasitional Research & Biobanking, Nottingham University Hospital NHS Trust

  • Gaining broad consent
  • Attaining clinical phenotype data
  • Maintaining confidentiality
  • Access to information
  • clock

    11:25

    The LifeGene story so far

    Jens  Mattsson

    Jens Mattsson, CEO, Lifegene Project

  • It is a national Swedish prospective cohort representing an infrastructure for research into diseases, with a lifespan approach starting with those that have their onset early and in midlife
  • It has a number of features making it unique, e.g. household based sampling, omics-ready biomaterial and the first study of children with complete pre- and perinatal data from both the mother and father
  • It takes advantage of Swedish strong ICT position and state of the art biobanking facilities
  • Researchers from Sweden and abroad can apply equally to withdraw phenotypic data and bio-specimens.
  • clock

    12:00

    Panel Discussion: ‘Public engagement barriers: obstacles to people donating tissue for biomedical research’

  • Developments in information technologies
  • The phantom Public
  • The ethics of passing on genomic data
  • Are there barriers?
  • Are the barriers due to processes or people?
  • Man H Zawati

    Man H Zawati , Lawyer and Academic Associate , McGill University Department of Human Genetics

    Celine  Lewis

    Celine Lewis, Public Engagement Lead STRATUM, Genetic Alliance

    Katherine Littler

    Katherine Littler, Policy Adviser, Welcome Trust

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    12:35

    Networking Lunch

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    13:35

    Biobanking in drug discovery

    Mads Roepke

    Mads Roepke, Scientist, Leo Pharma

  • How many samples pharmaceutical companies require for each phase of research
  • Sample type (e.g. frozen -80°c)
  • Clinical data required
  • clock

    14:10

    Where are my samples? Supply chain informatics in pre-competitive translational research

    Anthony Rowe

    Anthony Rowe, Principal Research Scientist, External Innovation R&D IT, Janssen

     

    ·          Pre-competitive research and translational studies
    ·          Underlying biology of complex disease and multiple research organisations
    ·          A new class of infrastructure to manage the flow of samples and information
    ·          Issues and risks of managing the logistics of samples beyond the walls of a biobank
    clock

    14:45

    Promoting the availability and maximising the value from UCLs many biospecimen collections with Tissue Access for Patient Benefit

  • Promoting the availability and maximising the value from UCL’s many biospecimen collections
  • Physical Biobanks at UCL - UCL-RFH Biobank and UCL/UCLH Biobank for studying health and disease
  • Challenges and experiences of setting up centralised infrastructure
  • Amir Gander

    Amir Gander, Senoir Knowledge Transfer Associate, UCL Medical School Royal Free Campus

    Kirstin Goldring

    Kirstin Goldring, Biobank Facilitator, University College London

    clock

    15:20

    Afternoon Tea

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    15:50

    From bench to clinic: the importance of healthy and diseased human tissue in discovering new therapeutics for respiratory disease

    Paul Whittaker

    Paul Whittaker, Direstor and Unit Head for Pre-Clinical Biomarkers, Respiratory Disease Area, Novartis

    • Human tissue is a crucial element in the discovery and validation of new targets and biomarkers
    • The need for tissue from well-phenotyped patient cohorts
    • Human tissue is a key link between animal model experiments and clinical trials
    • What do we need?
    • How much do we need?

    clock

    16:25

    The significance of the bio resource impact factor

    Raymond Dalgleish

    Raymond Dalgleish, Senior Lecturer, University of Leicester

  • The main objective of proposing a Bioresource Research Impact Factor (BRIF)
  • Cataloguing bioresource data access and sharing policies
  • The need for bioresources to be identified by a unique digital identifier
  • Specific requirements for citing bioresources
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    17:00

    How can biobanks contribute to Stratified Medicines?

    Martyn Foster

    Martyn Foster, Independent Consultant in Experimental Pathology, Independent Consultancy

  • The vision and key issues for stratified medicines research
  • The problem of ‘pathology phenotype’ versus ‘clinical phenotype’
  • Biobank sample collection: ‘opportunity-driven’ versus ‘event-driven’ versus ‘hypothesis-driven’
  • Interrogating the biobank: an iterative process
  • Case study: histopathology biobanks in COPD target validation and patient stratification
  • clock

    17:35

    Chairman’s Closing Remarks and Close of Day Two

    Julie Corfield

    Julie Corfield, Director, Areteva


    Director
    Areteva
    Joint Director, Centre for Integrated Genomic Medical Research
    University of Manchester
    Director of Biospecimen Research Network (BRN), Office of Biorepositories and Biospecimen Research (OBBR)
    National Cancer Institute
    Chair in Molecular Pathology
    Chernobyl Tissue Bank
    Head of HUNT Biobank, Leader Biobank Norway
    Norwegian University Of Science And Technology
    Biosample Operations Manager
    Roche Products
    Director of the Infectious Diseases BioBank
    Kings College London
    Associate Scientific Director
    Merck Research Laboratories
    Lawyer and Academic Associate
    McGill University Department of Human Genetics
    Director of R&D
    Nottingham University Hospital NHS Trust
    Public Engagement Lead STRATUM
    Genetic Alliance
    Policy Adviser
    Welcome Trust
    Scientist
    Leo Pharma
    Biobank Facilitator
    University College London
    Senoir Knowledge Transfer Associate
    UCL Medical School Royal Free Campus
    Senior Lecturer
    University of Leicester
    Independent Consultant in Experimental Pathology
    Independent Consultancy
    Lay Member
    NIHR Biomedical Research Centre
    CEO
    Lifegene Project
    Head of Human Biobank Unit
    Pasteur Hopital, University of Nice
    Biobank Informatics Manager
    Karolinska Institutet
    Partner
    Covington & Burling Llp
    Direstor and Unit Head for Pre-Clinical Biomarkers, Respiratory Disease Area
    Novartis
    MD
    ELPRO UK
    Associate
    Covington & Burling Llp
    Operations Manager Trasitional Research & Biobanking
    Nottingham University Hospital NHS Trust
    Chief operating officer
    Tissue Solutions
    Technical Project Manager
    Labvantage Solutions

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