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Antibodies and Antibody Drug Conjugates
9 April - 10 April 2018
Antibodies and Antibody Drug Conjugates

SAE Media Group is proud to present their 6th annual Antibodies and Antibody Drug Conjugates conference on the 9th-10th of April 2018. The Antibody-drug Conjugates market is expected to reach USD 30 Billion by 2023*. http://bit.ly/2hxLtOS

Antibodies and antibody drug conjugates (ADCs) have the potential to make a groundbreaking impact upon medicinal therapies, diagnostics and characterization of diseases. There is massive potential for ADCs to be used in the development of targeted solid tumour therapies, due to their ability to act as precisely and effectively on target antigens. 

Key topics that will be covered in the upcoming event include: fragment drug conjugates, ADC payloads, site-selective ADCs/ site-specific conjugation and the best linker and warhead combinations.

Hear from some of the best minds in the industry and partake in valuable discussion with key leaders within the field at this topical and timely event!

Conference agenda

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8:30

Registration & Coffee

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9:00

Opening Remarks and Introductions

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9:10

Regulatory Strategy

Peter Bach

Peter Bach, Director, BioPharmaLogic Ltd.

  • Biology for the regulatory arguments
  • CMC for nonclinical development
  • Staging the test item supply to speed the development
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    10:00

    Taking the conjugate into the clinic

    Peter Bach

    Peter Bach, Director, BioPharmaLogic Ltd.

  • Geographical differences
  • Finding clinical leverage
  • Global option for FTIH
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    10:40

    Morning Coffee

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    11:10

    Non-Clinical

    Peter Bach

    Peter Bach, Director, BioPharmaLogic Ltd.

  • Models
  • Service providers
  • Data interpretation
  • In vitro and in vivo safety assessments:

    - Literature Based Risk Assessment
    - Immunohistochemistry
    - CRO selection, Study design and CROs management

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    11:50

    Final considerations

    Peter Bach

    Peter Bach, Director, BioPharmaLogic Ltd.

  • Bioanalytical considerations
  • Agency interactions
  • The regulatory package
  • Outsourcing strategy – test item supply: matching nonclinical needs to speed the development
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    12:30

    Closing Remarks and End of Workshop

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    13:30

    Registration & Coffee

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    14:00

    Chairman's Opening Remarks

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    14:10

    Antibody Structure and Function

  • Comparison of the five classes of antibodies and their determined binding specificity
  • Analysis of structure-function relationships for antibodies
  • Examination of C domains and how these mediate function
  • Antibody Bioinformatics and relationship to structure and function. INN naming system.
  • Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

    Kerry Chester

    Kerry Chester, Professor, University College London

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    14:50

    Antibody Biophysics

  • Biophysical characterization of antibodies and ADCs
  • Methods for the determination of antibody-antigen binding affinities
  • Where is the limit for analysis of antibodies using biophysical methods?
  • Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

    Kerry Chester

    Kerry Chester, Professor, University College London

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    15:30

    Afternoon Tea

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    16:00

    Antibody Discovery

  • Analysis of sources (origins) of different antibodies
  • Strategies to accelerate antibody discovery
  • A look at current and emerging Antibody Discovery Technologies
  • Accelerating antibody discovery by protein expression
  • Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

    Kerry Chester

    Kerry Chester, Professor, University College London

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    16:40

    Antibody Conjugation

  • Methods of Antibody conjugation
  • Why is antibody-drug conjugation useful
  • The chemistry behind Antibody-Drug Conjugates
  • Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

    Kerry Chester

    Kerry Chester, Professor, University College London

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    17:20

    Closing Remarks

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Philip Howard, Chief Scientific Officer, Spirogen

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    9:10

    Use of modelling and simulation to compare new generation HER-2 ADCs with Kadcyla™: a focus on PK and efficacy

    Alison Betts

    Alison Betts, ADC Scientist, Pfizer

  • Kadcyla is a HER-2 ADC approved in 2013 for patients with HER2+ metastatic breast cancer
  • Kadcyla is only efficacious in high HER2 tumors and patients are acquiring resistance
  • New generation HER-2 ADCs are being designed to overcome these limitations
  • PK/PD  methodologies for efficacy and safety differentiation will be presented
  • For PK predictions a mechanistic target mediated drug disposition model is proposed accounting for binding to shed HER-2 extracellular domain and variability across patients
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    9:50

    Application of a PK-PD Modeling & Simulation in Antibody-Drug Conjugate Development

    Aman Singh

    Aman Singh, PK-PD Scientist, Janssen

  • Preclinical to clinical translation
  • Bystander effect of ADCs
  • Binding site barrier of ADCs
  • Cell-level pharmacokinetics of ADCs
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    10:30

    Morning Coffee

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    11:00

    GlycoConnect™ and HydraSpace™ technologies for superior Antibody-Drug Conjugates

    Sander van Berkel

    Sander van Berkel, Director R&D Operations, Synaffix

  • Head-to-head comparison demonstrates superiority of Glycan-Conjugated ADCs (GlycoConnect™) versus mainstream technologies 
  • Readily adaptable HydraSpace™ enables highly hydrophobic payloads, dual warhead ADCs and further expands TI
  • Decomposition of Parameters Contributing to the Improved Therapeutic Index
  • GlycoConnect™ and HydraSpace™
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    11:40

    Antibody Targeted Amanitin Conjugates (ATACs) - Expanding the ADC landscape with a new payload targeting RNA Polymerase II

    Andreas Pahl

    Andreas Pahl, CSO, Heidelberg Pharma

  • Antigen-Targeted Amanitin-Conjugates (ATACs) represent a new class of ADCs using the payload Amanitin.
  • This payload introduces a novel mode of action into oncology therapy, the inhibition of RNA polymerase II.
  • The technology platform includes Amanitin supply, site-specific conjugation, demonstrated safety profile and biomarker.
  • HDP-101 is the first ATAC directed against BCMA entering Phase I trials by the end of 2018
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    12:20

    Networking Lunch

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    13:30

    Minor-Groove binding DNA-interactive molecules as ADC Payloads - the impact of sequence-selectivity and mono-alkylation versus cross-linking

    David E. Thurston

    David E. Thurston, Professor of Drug Discovery, King's College London

  • The impact of mono-alkylation versus intra- and interstrand cross-linking mechanisms of action on the in vitro and in vivo efficacy and toxicity of ADC payloads and ADCs.
  • Is there an opportunity to match the sequence-selectivity of DNA-interactive payloads to the genetic profiles of tumour types?
  • Is there an opportunity to improve the therapeutic window of ADCs by “tuning” the mechanism of action and sequence-selectivity of the payload?
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    14:10

    PBDs – update on an efficient and effective payload class

    Arnaud Tiberghien

    Arnaud Tiberghien, Scientist II, Chemistry, Spirogen

  • A potent and flexible class of ADC payloads and their industrial processing viability.
  • Whether or not PBDs make better payloads than others.
  • Comparison of PBD DNA crosslinkers and PBD DNA alkylators
  • New PBD payloads in developments. Consequences on mode of action, efficacy and tolerability
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    14:50

    Afternoon Tea

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    15:20

    Novasep’s integrated solutions for ADCs

    Francois D'Hooge

    Francois D'Hooge, Head of Bioconjugation, Novasep S A S

  • Simplifying the supply chain through an integrated offer
  • Design considerations of a dedicated conjugation facility
  • Novasep’s strengths for ADCs: case studies
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    16:00

    Precision cancer therapy ADCs with novel target, antibody and cancer toxin technologies

    Robert Boyd

    Robert Boyd, UK Site Head and Scientific Director, Oxford BioTherapeutics

  • Selection of novel ADC cancer targets in the post-genomics era
  • Improved efficacy by optimizing targets to ADC technologies
  • Target Selection criteria - how to choose the best target for your specific need
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    16:40

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

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    9:10

    Antibody-Pyrrolobenzodiazepine Conjugates

    Philip Howard, Chief Scientific Officer, Spirogen

  • An overview of the PBB ADC Clinical landscape
  • Present 3 case studies on PBD-ADCs for haematological indications
  • Present 1 case study on a PBD-ADC in a solid indication
  • Case studies will include both clinical and preclinical data
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    9:50

    Site-selective ADCs by disulfide bridging

    James Baker

    James Baker, Chemistry Lecturer, University College London

  • Site-selective ADCs offer the prospect of improved Therapeutic Indexes over traditional heterogeneous conjugation approaches, and are likely to form the basis of next generation ADCs.
  • Can achieve such site-selectivity by targeting the four interchain disulfide bonds (in IgG1s), using bridging reagents which reconnect the two cysteine residues.
  • We describe the development of Next Generation Maleimide reagents, and the related Pyridazinediones, as optimised platforms for ADCs constructed in this way.
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    10:30

    Morning Coffee

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    11:00

    Antibody Fragment Drug Conjugates (FDCs): A tailored therapy for solid tumours

    Mahendra  Deonarain

    Mahendra Deonarain, Chief Scientific and Operating Officer, Antikor Biopharma Ltd.

  • Discovery of antibody fragments specifically designed for FDCs
  • Manufacture of FDCs and payload screening
  • In vivo pharmacokinetics and tumour cure efficacy in gastric cancer models
  • Rodent models for toxicology and tolerability
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    11:40

    Design principles for maximizing the drug delivery efficiency and therapeutic index of ADCs

    Robert Lyon

    Robert Lyon, Senior Director Protein Sciences, Seattle Genetics Ltd

  • The conjugation of drug-linkers to an antibody can result in increased nonspecific uptake and catabolism in healthy tissues
  • This phenomenon has two potential negative consequences—unintended delivery of the drug to non-target tissues, and diminished exposure of the tumor to the ADC
  • Careful design of the drug-linker can minimize this effect in preclinical models, with demonstrable decreases in drug concentrations in normal tissues paired with maximal delivery to the tumor
  • Toxicology and xenograft studies indicate that the optimized design both decreases off-target toxicity and improves antitumor activity, and we are currently planning to evaluate this design clinically with an anti-CD48 antibody for patients with multiple myeloma
     
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    12:20

    Networking Lunch

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    13:30

    Highly Potent APIs (HPAPIs) in ADC projects

    Justin Mason-Home

    Justin Mason-Home, Director, HPAPI Project Services Limited

  • ADC Toxicants in the context of Pharma HPAPIs
  • Other ADC Component Hazards
  • Health and Safety Project Elements in Designing and Delivering HPAPI Projects
  • Risk Assessment, Risk Communication and Risk Management
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    14:10

    Anthracycline-based antibody drug conjugates with potent immune-stimulatory functions

    Roger Beerli

    Roger Beerli, CSO, NBE Therapeutics

  • Site-specific conjugation using sortase enzyme (SMAC™-Technology), yielding homogenous ADCs.
  • Highly potent payload, providing access to difficult-to-address targets.
  • Anthracycline-based payload with attractive IO properties.
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    14:50

    Afternoon Tea

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    15:20

    The use of Nanobody formatting to improve immune-oncology therapeutics

    Carlo Boutton

    Carlo Boutton, Director of Technology, Ablynx

  • Small Nanobodies® with their modular design are a perfect starting point for generating multivalent and multispecific therapeutics for immune modulation.
  • The power of the platform and its flexibility to develop optimal drug formats will be demonstrated by a multivalent approach for an agonistic Nanobody against the co-stimulatory immune checkpoint receptor GITR and a multispecific T-cell recruitment format.
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    16:00

    The use of bispecific antibodies to modulate anti-tumour immune responses

    Delphine Buffet

    Delphine Buffet, Senior Research Associate, F-star

  • Bispecific antibodies: an attractive alternative to cancer treatments combinations
  • F-star’s approach to create bispecific mAb²
  • In vitro and in vivo efficacy of F-star bispecific antibodies targeting oncology pathways
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    16:40

    Chairman’s Closing Remarks and Close of Day Two

    Official Media Partner

    Supporters

    [SPEAKER INTERVIEW] - Robert Lyon, Senior Director Protein Sciences, Seattle Genetics

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    [ATTENDEE LIST] - LIST OF COMPANIES & JOB TITLES

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    [SPEAKER INTERVIEW] - Mahendra Deonarain, Chief Executive and Scientific Officer, Antikor Biopharma

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    [2016 PRESENTATION] - SKAN

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    [2016 PRESENTATION] - NBE Therapeutics

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    [SPEAKER INTERVIEW] - Alison Betts, Associate Research Fellow, Pfizer

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    ADC Review / Journal of Antibody-drug Conjugates (ISSN: 2327-0152) is an international publication combining professional social media with an online-only, hybrid open-access, peer reviewed journal. The Journal aims to serve the needs of a diverse community of individuals including academia, life sciences, pharma, (basic, translational and clinical) research, clinicians, along with regulatory affairs, government authorities and representatives from payers, and policy makers. Key information includes peer-reviewed articles, news features, discussions, blogs, and a knowledge center offering the latest and most relevant information about Antibody Drug Conjugates (ADCs), BiSpecific Antibodies, Site Specific Antibody Drug Conjugates, Small Molecule Drug Conjugates (SMDC), and Engineered Antibody Fragments. The purpose of the Journal is to present this information in an understandable and a useful format for all stakeholders.

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