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Therapeutic Antibodies
28 June - 29 June 2004
Therapeutic Antibodies
Announcing SAE Media Group's 5th Annual event... For the 5th year running, SAE Media Group will bring together key experts in the field to provide a platform for networking and discussion

A unique opportunity to learn from leading industry experts including:
· Dr Alejandro Aruffo, President, Abbott Bioresearch Center, Abbott
· Dr David Glover, Chief Medical Officer, Cambridge Antibody Technology
· Dr Vivian Albert, Vice President, Preclinical Research & Development, Human Genome Sciences
· Dr Joseph Bolen, Senior Vice President, Research & Drug Discovery, Millennium
· Dr Lutz Jermutus, Director, Antibody Engineering, Cambridge Antibody Technology
· Dr Eileen Elliott, Senior Director Immunology Biology, Pfizer
· Dr René Hoet, Director, Research & Technology, Dyax
· Dr Jane Osbourn, Vice President, Display Technology, Cambridge Antibody Technology
· Dr Leon Hooftman, Head, Clinical Development, Celltech
· Dr Simon Hufton, Director, Research & Technology, Dyax
· Dr Thomas von Rueden, Executive Vice President, Business Development & Chief Scientific Officer, MorphoSys

Hot topics to be covered at this event include:
· MARKET TRENDS: Look at key trends and predictions to 2008: How can you capitalise on the ‘fully human wave?’
· ANTIBODY TECHNOLOGIES: Identify the latest developments in ribosome, yeast and phage display technologies
· ONCOLOGY ANTIBODIES: Assess novel immunomodulatory approaches for cancer and hear about current projects from leading companies
· SYNTHETIC THERAPEUTIC ANTIBODIES: Discover the application of structure-based design to therapeutic antibody development
· CASE STUDIES: Meet leaders in the field and learn from their mixed experiences in oncology and other therapeutic areas including inflammatory and infectious diseases

Conference agenda

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8:30

Registration and Coffee

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9:00

Chairman's Opening Remarks

Dr Lutz Jermutus

Dr Lutz Jermutus, Director, Antibody Engineering, Cambridge Antibody Technology

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9:10

THE THERAPEUTIC ANTIBODIES MARKET

Dr Alex Pavlou

Dr Alex Pavlou, Head, Biotechnology Analysis / Member, Datamonitor / European Federation of Biotech

  • The market size growth and key trends to 2008 (in terms of technological platform: human, humanised, chimeric etc.)
  • Key therapeutic trends: key indications to 2008 and revenue performance
  • Leading brands: the size of the new wave of antibody blockbusters
  • The evolution of the Ab biotech business models and key industry challenges
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    9:40

    ANTIBODY DISCOVERY: RIBOSOME DISPLAY TECHNOLOGIES

    Dr Jane Osbourn

    Dr Jane Osbourn, Vice President, Display Technology, Cambridge Antibody Technology

  • Overview of the ribosome display process
  • Advantages of ribosome display over other display systems
  • Application of ribosome display to potency engineering
  • Other applications of ribosome display
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    10:20

    PROTEIN ENGINEERING BY YEAST SURFACE DISPLAY

    Dr K Dane Wittrup

    Dr K Dane Wittrup, JR Mares Professor of Chemical Engineering & Bioengineering, Massachusetts Institute of Technology

  • Novel comprehensive mutagenesis strategies integrating recombination and point mutation
  • Intrabody development by yeast surface display
  • Expression maturation of difficult antigens
  • Fibronectin-domain and single-domain antibody display
  • Shotgun epitope mapping by yeast surface display
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    11:00

    Morning Coffee

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    11:20

    COMBINATORIAL YEAST MATING TECHNOLOGY

    Dr Simon Hufton

    Dr Simon Hufton, Director, Research & Technology, Dyax

  • Affinity maturation of Fab antibodies by yeast display
  • Development of novel technology for the rapid construction of Fab antibody repertoires using combinatorial yeast mating
  • Facilitates rapid and iterative chain shuffling of antibody vs genes
  • Rapid construction of large naïve yeast displayed fab antibody libraries
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    12:00

    THE LATEST DEVELOPMENTS IN ANTIBODY PHAGE DISPLAY TECHNOLOGY

    Dr René Hoet

    Dr René Hoet, Director, Research & Technology, Dyax

  • Construction and use of Dyax novel phage and phagemid human antibody libraries
  • Novel antibody diversity combining careful synthetic design with natural human donor diversity
  • Automated controlled phage display selection methods on purified protein targets, peptides and cells
  • High-throughput screening methods to identify antibody leads
  • Examples of therapeutic antibody leads from Dyax antibody pipeline
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    12:40

    Networking Lunch

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    14:00

    FROM TARGET IDENTIFICATION AND VALIDATION TO THERAPEUTIC ANTIBODY LEADS

    Kristian Jensen

    Kristian Jensen, Group Leader, Xerion Pharmaceuticals

  • Successful selection of phage display libraries against cell surfaces
  • Efficient target validation using chromophore-assisted laser inactivation (CALI) technology
  • Combination of phage display, CALI and mass spectrometry produces a technology platform for the systematic identification and functional validation of novel drug targets
  • Examples from the validation, identification and therapeutic antibody lead generation against cancer and angiogenesis targets
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    14:40

    SYNTHETIC THERAPEUTIC ANTIBODIES

    Frederic Fellouse

    Frederic Fellouse, Senior Research Associate, Genentech

  • High affinity antibodies derived from synthetic repertoires
  • Structural and functional analysis of antigen recognition
  • Highly optimised synthetic libraries with limited amino acid diversities
  • Implications for antibody engineering and therapeutic applications
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    15:20

    Afternoon Tea

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    15:40

    SEARCHING FOR NOVEL TARGET MOLECULES ON TUMOUR CELLS

    Dr John de Kruif

    Dr John de Kruif, Director, Antibody Technology, Crucell

  • Selections on tumour samples
  • Downstream processing isolated clones
  • Target identification using expression cloning and MS
  • Characterisation of novel molecules
  • Technology evaluation
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    16:20

    A HUMAN CTLA4-SPECIFIC ANTIBODY

    Dr Eileen Elliott

    Dr Eileen Elliott, Senior Director, Immunology Biology, Pfizer

  • Discovery
  • >In vitro characterization
  • Biomarkers of activity
  • Clinical status
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    17:00

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Re-registration and Coffee

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    9:00

    Chairman's Opening Remarks

    Dr Alex Pavlou

    Dr Alex Pavlou, Head, Biotechnology Analysis / Member, Datamonitor / European Federation of Biotech

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    9:10

    MLN 2704 – A TOXIN-CONJUGATED HUMANISED MAB DIRECTED AGAINST THE PROSTATE SPECIFIC MEMBRANE ANTIGEN FOR TREATMENT OF ANDROGEN-INDEPENDENT PROSTATE CANCER

    Dr Joseph Bolen

    Dr Joseph Bolen, Senior Vice President, Research & Drug Discovery, Millennium

  • Target identification
  • Target validation
  • MLN 2704 development
  • Status of MLN 2704 clinical trials
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    9:40

    AGONISTIC APOPTOSIS-INDUCING ANTIBODIES FOR THE TREATMENT OF CANCER

    Dr Vivian Albert

    Dr Vivian Albert, Vice President, Preclinical Research & Development, Human Genome Sciences

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    10:20

    CHALLENGES IN THE CLINICAL DEVELOPMENT OF A MONOCLONAL ANTIBODY FOR BREAST CANCER

    Dr Tamas Suto

    Dr Tamas Suto, Clinical Scientist, F Hoffmann-La Roche

  • Herceptin®: past and future
  • Herceptin® clinical development
  • Challenges: cardiac events, pharmacokinetics
  • Linking molecular diagnostics to therapy
  • Integrated approach to breast cancer
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    11:00

    Morning Coffee

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    11:20

    SUPERAGONISTIC CD28-SPECIFIC ANTIBODIES

    Dr Thomas Hanke

    Dr Thomas Hanke, Chief Scientific Officer, TeGenero

  • Company strategy
  • Technological concept
  • Immunoreconstitution and immunosuppression
  • Therapeutic potential of superagonistic anti-CD28 antibodies
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    12:00

    HUMAN ANTIBODY DEVELOPMENT: HUMIRA - A CASE STUDY

    Dr Alejandro Aruffo

    Dr Alejandro Aruffo, President, Abbott Bioresearch Center

  • Identification of human anti-TNF mAb
  • Affinity maturation of human anti-TNF mAb
  • Overview of HUMIRA clinical development
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    12:40

    Networking Lunch

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    14:00

    CLINICAL DEVELOPMENT OF PEGYLATED ANTIBODY FAB’ FRAGMENTS

    Dr Leon Hooftman

    Dr Leon Hooftman, Head, Clinical Development, Celltech

  • Humanised PEG conjugate
  • Pharmacokinetics
  • CDP 870, anti-TNF
  • CDP 484, anti-ILbeta
  • Disease indications
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    14:40

    DEVELOPING MONOCLONAL HUMAN ANTI-TOXIN THERAPIES FOR ANTHRAX

    Dr Martha Wild

    Dr Martha Wild, Lead, Principal Scientist, Anthrax Programme, Alexion Antibody Technologies

  • Source for library construction
  • Anti-toxin attributes from Fab to mAb
  • Defining mechanism of action
  • Desired qualities for anti-toxin therapy
  • Production considerations and issues in building an emergency stockpile
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    15:20

    Afternoon Tea

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    15:40

    TRABIO

    Dr David Glover

    Dr David Glover, Chief Medical Officer, Cambridge Antibody Technology

  • The concept: prevention of excessive scaring after eye surgery
  • The molecular target: transforming growth factor beta2
  • The progress: from concept to phase III clinical trials
  • The learning points: for the company and the programme
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    16:20

    TREATING INFLAMMATORY DISEASES

    Dr Jutta Haunschild

    Dr Jutta Haunschild, Director, Research & Development, MorphoSys

  • Validation of ICAM1 as therapeutic target
  • First fully human antibodies targeting ICAM1
  • In vitro profiling
  • In vivo efficacy in psoriasis animal models
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    17:00

    Chairman's Closing Remarks and Close of Conference

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

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