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Translation from Model to Man and Back
9 June 2010
Translation from Model to Man and Back

About the workshop

When progressing a drug from Discovery to Development, one question always surfaces: "How predictive are our models?"  The estimation of effectiveness in the clinic becomes even harder with more and more drugs in the pharmaceutical pipeline being First in Class.

The heterogeneous pain patient population provides, not only a plethora of possible targets, but also opportunities for personalised medicine.  There is a growing need to meet up personalised medicine initiatives in the preclinical setting, addressing the question "What do we want to predict?"

This workshop will address the gap between Discovery and Development and the translational tools used to bridge that gap.

Scroll down for the full workshop programme...

 

About the workshop leader

Karin Hygge Blakeman PhD, Team Leader, AstraZeneca

Karin has twelve years of experience in working on mechanisms of pain primarily by using behavioural models of pain.  Since joining AstraZeneca in 2003, her work has focused on pre-clinical models of analgesia and in vivo pharmacology.

Dr Hygge Blakeman received her PhD in Neurophysiology at the Karolinska Institute, Sweden, in 2002.  Upon graduation, she joined AstraZeneca as a Senior Research Scientist, designing and conducting in vivo testing for new analgesic compounds.  Later that year, she accepted a Global AstraZeneca Post Doctoral position, developing a model to study gait patterns in the monoarthritic rat.  In 2005, Dr Hygge Blakeman was appointed Team Leader at AstraZeneca, heading a group responsible for the behavioural models of pain at AstraZeneca.  The group provides critical in vivo data for progressing potential new pharmaceuticals in the AstraZeneca analgesia pipeline.

Co-presenters at the workshop will include:

  • Kristina Holmberg, Team Leader, Pfizer
 Karin Hygge Blakeman photo
 AstraZeneca Logo

About the organisation

AstraZeneca is one of the world's largest pharmaceutical companies, with a presence in over 100 countries across the globe.  It was formed by a merger of Astra AB and Zeneca Group on 6 April 1999.  It now employs over 65,000 people with major R&D sites in Sweden, the UK and USA, corporate offices in London (UK) and other sites in important emerging markets, including China.

The company has a broad range of products, but focuses its resources on six therapy areas - cancer, cardiovascular, gastrointestinal, infection, neuroscience and respiratory & inflammation.  In 2008, sales totalled $31.6 billion, over $5 billion of which was invested in R&D.

www.astrazeneca.com

Workshop agenda

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8:30

Registration and coffee

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9:00

Welcome and introductions

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9:10

Preclinical translational biomarkers - can they make a difference?

  • Kristina Holmberg, Team Leader, Pfizer
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    10:10

    Morning coffee

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    10:30

    Translational challenges in analgesia

  • Karin Hygge Blakeman, Team Leader, AstraZeneca
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    11:30

    Discussion session

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    12:00

    Close of workshop

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