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Cell-Based Assays
22 November - 23 November 2010
Cell-Based Assays

 
SAE Media Group is pleased to announce its third annual conference on Cell-Based Assays, due to take place in London on Monday 22nd and Tuesday 23rd November 2010.


About the conference

Now that the majority of screening assays employ the use of cell-based technologies, robust cell-based assays are essential for lead identification and the optimisation of therapeutic candidates.

Factors including the ever increasing numbers of compound failures and rapidly escalating costs of R&D are driving the uptake of increasingly biologically relevant surrogates in cell-based assays to predict the response of drug candidates - leading to developments in areas including stem cell use in screening programmes, 3D cell cultures and label-free detection.

These technologies, and the effective techniques and methods employed in their use have been progressing at breakneck speed and this conference will assemble leading experts from both industry and academia to present you with the latest updates, technologies and critical strategies in a practical, case study focused environment.

  • Hear about new techniques, technologies and methods used in cell-based assays
  • Discuss the use of stem cells in discovery and development
  • Explore the powers of RNAi screening in target discovery and biomarker identification
  • Learn from multiple case studies demonstrating real life data and processes that work
  • Network with key industry associates and solution providers to share valuable experiences

Why not attend the associated workshop as well?

Associated with the conference there will be a half-day interactive workshop on "Cell-based assay preparation for high content analysis and troubleshooting strategies", taking place on 24th November.  It will cover an advanced look into cell based assay preparation for high content analysis and troubleshooting strategies. This will be led by Anthony Mitchell Davies, Director of the high content facility at Trinity College Dublin.  To see more information about the workshop, please see the workshop page.

 

Cell-Based Assays Image 

Keen to see the detailed programme? Click here.

Want to download the brochure?  Click here.

Want to register your place? Click here.

Make a group booking - discounts apply


 

Who is chairing this event?

Day One

Dame Julia Polak
Faculty of Medicine, Regenerative Medicine Consortium
Imperial College London

Day Two

Darren Cawkill
Associate Director
Pfizer

 

Who is speaking at this event?

Our keynote speakers

Stephen Rees
Director, Screening and Compound Profiling
GlaxoSmithKline

Claudine Grépin
Head of Assay Development & Screening
Sanofi-Aventis

Glyn Stacey
Director of the UK Stem Cell Bank
NIBSC

Our expert speakers

Anders Damholt, Head of Target Validation, AstraZeneca

Andreas Scheel, Director, Assay Development, (OSI) Prosidion

Derek Trezise, Director, European Discovery Services, Essen BioScience

Frank Verdonck, Senior Scientist, Team Leader Cell-Based Screening, Ablynx

John Curnow, Institute of Biomedical Research, University of Birmingham

John Westwick, President and CEO, Odyssey Thera

Katharina Maniura, Head of Research Program Materials for Health and Performance, EMPA

Laura DeForge, Senior Scientist, Assay & Automation Technology, Genentech

Leo Price, Division of Toxicology, Leiden-Amsterdam Center for Drug Research, Leiden University

Markus Schmitz, Research & Development in Cellular Analysis, Roche Diagnostics

Oliver Nayler, Director, Head, Cardiovascular & Fibrosis Biology, Actelion Pharmaceuticals

Pamela Tranter, Group Head, Automated Electrophysiology, Novartis

Paula McArdle, Scientist, Assay Sciences and Screening Group, AstraZeneca

Roderick Beijersbergen, Head NKI Robotics and Screening Center, The Netherlands Cancer Institute

Stefan Przyborski, Founder and CSO, Reinnervate

See the full agenda

 

Conference agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

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9:10

Advanced assay preparation for HCS/A

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9:50

Cellular physiology and the assay plate environment

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10:30

Morning Coffee

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11:00

A troubleshooting table quiz - "Problems and Solutions"

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11:30

Discussion session

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12:00

Close of workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Dame Julia Polak

Dame Julia Polak, Faculty of Medicine, Regenerative Medicine Consortium, Imperial College London

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9:10

The challenges and opportunities of cell-based assays in drug discovery

Stephen Rees

Stephen Rees, Director, Screening and Compound Profiling, GlaxoSmithKline

  • Trends, developments and technology advancements
  • Current challenges being faced and how we can overcome these hurdles
  • Getting the most out of existing platforms
  • Case study: identifying a novel compound
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    9:45

    Label free, high content cellular analysis

    Markus Schmitz

    Markus Schmitz, Research & Development in Cellular Analysis, Roche Diagnostics

  • Improved hepatotoxicity analysis
  • xCELLigence system - gene expression and imaging workflows
  • assessment of compounds with pro-arrhythmic liabilities
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    10:25

    Morning Coffee

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    10:55

    Real time cell analysis as a tool to select potent Nanobodies® reducing cancer cell proliferation

    Frank Verdonck

    Frank Verdonck, Senior Scientist, Team Leader Cell-Based Screening, Ablynx

  • Real time cell analysis versus classic read out methods
  • Selection of target-specific Nanobodies®
  • Potency determination of monovalent and formatted target-specific Nanobodies®
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    11:30

    High fidelity live-cell imaging assays for key biological processes: the power of kinetics

    Derek Trezise

    Derek Trezise, Director, European Discovery Services, Essen BioScience Ltd

  • Novel approaches to measuring cell migration, angiogenesis, apoptosis & proliferation
  • End point vs kinetic measures
  • Dissecting pathways and compound mechanism of action: mono & co-cultures
  • Phenotypic screening & gene interference (siRNA, shRNA) profiling
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    12:10

    Networking Lunch

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    13:10

    Stem cells as tools to improve in vitro toxicity models of different tissue types

    Glyn Stacey

    Glyn Stacey, Director of the UK Stem Cell Bank, National Institute For Biological Standards And Control

  • Impact of stem cells vs. cell lines
  • How the field is developing and affecting biopharmaceutical development
  • Applications, implementation issues and solutions
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    13:45

    Interactive Panel Discussion

    Topics include:

  • Innovative implementations, approaches and achievements
  • Ethics, safety and regulations
  • Implications for target discovery and lead generation
  • Identifying the challenges facing stem cells and developing solutions

    Please submit your questions in the box provided at the conference or email to smiproduction@smi-online.co.uk 

  • Dame Julia Polak

    Dame Julia Polak, Faculty of Medicine, Regenerative Medicine Consortium, Imperial College London

    Stephen Rees

    Stephen Rees, Director, Screening and Compound Profiling, GlaxoSmithKline

    Glyn Stacey

    Glyn Stacey, Director of the UK Stem Cell Bank, National Institute For Biological Standards And Control

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    14:20

    Hitting cancer where it hurts most!

    Roderick Beijersbergen

    Roderick Beijersbergen, Associate Professor Division of Molecular Carcinogenesis and Head NKI Robotics and Screening Center, The Netherlands Cancer Institute

  • Synthetic lethal screening
  • Mechanism of drug action
  • Identification of drug resistance
  • High throughput high content screening
  • Cancer screening cell based models
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    14:55

    GPCR signalling assays in drug discovery using primary cells

    Oliver Nayler

    Oliver Nayler, Director, Head, Cardiovascular & Fibrosis Biology, Actelion Pharmaceuticals

  • Developments in the field of label-free technologies
  • Recombinant cells vs. non-recombinant GPCR signalling
  • Case study: Optimising primary cell HTS in discovery
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    15:30

    Afternoon Tea

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    16:05

    Using siRNA screening for target hunting in drug discovery: A case study

    Anders Damholt

    Anders Damholt, Head of Target Validation Team, AstraZeneca

  • Screening on disease-relevant in vitro models: Assay strategies and models
  • Extracting information using pathway analysis and other systems biology tools
  • Advantages and drawbacks by using siRNA screening for target identification
  • clock

    16:35

    Strategies for GPCR functional assays in Drug Discovery

    Andreas Scheel

    Andreas Scheel, Director, Assay Development, OSI Pharmaceuticals

  • Pitfalls with recombinant cellular systems
  • Utility of different assay formats
  • Case study: From recombinant systems to in vivo studies - what comes in between
  • clock

    17:05

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Darren  Cawkill

    Darren Cawkill, Senior Principal Scientist , Pfizer

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    9:10

    Case studies in high throughput, high content screening

    Claudine Grépin

    Claudine Grépin, Head of Assay Development & Screening, Sanofi-Aventis

  • Presentation of some high content assay formats adapted to high throughput screening
  • Lessons learned 
  • Added value for hit to lead process
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    9:45

    Development of a unique scaffold enabling the growth of complex 3D tissue cultures

    Stefan Przyborski

    Stefan Przyborski, Founder and CSO, Reinnervate

  • 3D growth following easy to use protocols
  • Exploring the compatibility with standard molecular and cellular assay techniques
  • Comparison of 2D vs. 3D cell culture growth and performance
  • Demonstrating utility in industry and specialised tissues including bone, liver and skin
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    10:25

    Morning Coffee

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    10:50

    Developments in ion channel assay technologies and techniques

    Pamela Tranter

    Pamela Tranter, Group Head, Automated Electrophysiology, Novartis

  • Emerging measurement technologies
  • Novel ion channel targets
  • Hurdles to overcome
  • Assessing non-voltage gated channels effectively
  • clock

    11:05

    Real-time impedence-based Bioassays using the xCELLigence technology

    Laura DeForge

    Laura DeForge, Senior Scientist, Assay & Automation Technology, Genentech

  • Principle of operation
  • Analyzing xCELLigence data
  • Case studies: correlating changes in impedance with traditional assay endpoints
  • clock

    12:00

    Expediting preclinical drug development via high content analysis of cellular networks

    John Westwick

    John Westwick, President and CEO, Odyssey Thera Inc

  • Live cell, protein complex-based high-content signal transduction assays
  • Platform enables High-Content screening and profiling in high throughput
  • Development of broad drug and toxicant activity database
  • Defining therapeutic candidate mechanisms, selectivity, safety
  • Case study: identifying optimal candidates throughout the drug development process
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    12:35

    Networking Lunch

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    13:35

    High content biology applications in oncology drug discovery

    Paula McArdle

    Paula McArdle, Scientist, Assay Sciences and Screening Group, Cancer and Infection Research Area, AstraZeneca

  • Successful Integration of High Content Biology into Drug Discovery
  • Comparison of current HCS platforms
  • Recent examples of best use of multiple platforms in a screening environment
  • clock

    14:10

    Quantitative light microscopy employed in analysing motion and chemotaxis of metastatic cells

    Daniel Zicha

    Daniel Zicha, Head of Light Microscopy, Cancer Research UK

  • Techniques
  • Mechanisms
  • Consequences for approaches to drug discovery
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    14:45

    Functional genomics and compound screening with high content 3D cancer invasion models

    Leo Price

    Leo Price, Division of Toxicology, Leiden-Amsterdam Center for Drug Research, Leiden University

  • Optimising a relevant 3D biology for screening
  • Miniaturising 3D cultures
  • High throughput 3D imaging
  • Multiparameter feature extraction and analysis
  • clock

    15:20

    Afternoon Tea

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    15:45

    Micro 3D cell culture devices for cell-based sensing and drug screening

    Katharina Maniura

    Katharina Maniura, Head of Research Programme Materials for Health and Performance, EMPA

  • Functionalising micro-well surfaces to mimic ECM and neighbouring cell interaction environments
  • Controlling specific cell functions
  • Translation into drug discovery and screening programs
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    16:20

    Multiparameter analysis for immune cell identification and function

    S. John Curnow

    S. John Curnow, Institute of Biomedical Research, University Of Birmingham

  • Analysis of T cell heterogeneity and function by multi-colour flow cytometry
  • Purification of immune cell subsets to study their function
  • Testing the effects of drug compounds on immune cell function in vitro
  • Identifying defects of immune cell function in disease
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    16:55

    Chairman’s Closing Remarks and Close of Day Two

    Marriott Regents Park

    128 King Henry's Road
    London NW3 3ST
    United Kingdom

    Marriott Regents Park

    This 4 star north London hotel in zone 2 is the perfect destination for the astute business traveler as well as the leisure guest that knows how convenient north London hotels are, as a base from which to explore the city .Bond Street is just 3 stops from Swiss Cottage underground station on the Jubilee Line, so you can be shopping, exploring the sights and taking in one of London’s world-renowned West End shows in less than 15 minutes when you stay at this hotel near central London. At the same time, the hive of activity that is Camden Town, the chic shops, cafes and restaurants of Primrose Hill and ZSL’s London Zoo in Regents Park are all just a short walk from this hotel in north London.

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    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

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