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Superbugs & Superdrugs

Antibiotics have been one of the most transformational discoveries in medicine saving millions of lives around the world. The rise of resistance poses an unprecedented threat to public health rekindling a drive for new, effective and safe drugs to beat the superbugs, combined with efforts to raise awareness around the use of antimicrobials.

 This conference takes a holistic look at the issues and aims to equip delegates to take on the challenges of conserving the effectiveness of existing antibacterial drugs, developing new ones and tackling biosecuiry and Ebola threats. Bringing in voices from pharma, academia, government, regulatory perspectives, consultants and funding bodies this conference is the ideal meeting place to share the latest updates, case studies and strategies to seize the opportunities ahead and  usher in the next generation of superdrugs.

 

 

 

FEATURED SPEAKERS

Colin J Suckling

Colin J Suckling

Research Professor of Chemistry, University of Strathclyde
David Spring

David Spring

Professor of Chemistry , Cambridge University
Domingo  Gargallo-Viola

Domingo Gargallo-Viola

Chief Scientific Officer, ABAC Therapeutics
Jorge Mestre-Ferrandiz

Jorge Mestre-Ferrandiz

Director of Consulting, Office of Health Economics (OHE)
Neil Stokes

Neil Stokes

Head of Biology, Redx Anti-Infectives
Richard Bergstrom

Richard Bergstrom

Director General, EFPIA

Colin J Suckling

Research Professor of Chemistry, University of Strathclyde
Colin J Suckling

David Findlay

Commercial Director, II-ID Global Franchise, GlaxoSmithkline
David Findlay

David Scott

Licensing & Business Development Consultant, PharmaConsulting
David Scott

David Spring

Professor of Chemistry , Cambridge University
David Spring

David Williams

Chief Executive Officer, Discuva
David Williams

Dawn Firmin

Head of Project Management , MGB Biopharma
Dawn Firmin

Domingo Gargallo-Viola

Chief Scientific Officer, ABAC Therapeutics
Domingo  Gargallo-Viola

Fiona Marston

Chief Executive, Absynth Biologics
Fiona Marston

Frederick Wittke

Medical Director , Debiopharm International
Frederick  Wittke

Ian Friedland

Chief Medical Officer, Achaogen, Inc.
Ian  Friedland

Jerome Gabard

CEO, Pherecydes
Jerome  Gabard

Jorge Mestre-Ferrandiz

Director of Consulting, Office of Health Economics (OHE)
Jorge Mestre-Ferrandiz

Melissa Stundick

Acting Branch Chief, Broad Spectrum Antimicrobials Program, BARDA
Melissa Stundick

Neil Stokes

Head of Biology, Redx Anti-Infectives
Neil Stokes

Patricia Paukovits

Scientific Officer, European Commision
Patricia  Paukovits

Richard Bax

Senior Partner, TranScrip Partners
Richard Bax

Richard Bergstrom

Director General, EFPIA
Richard Bergstrom

Ryan Cirz

Director of Biology , Achaogen
Ryan  Cirz

Timothy Jinks

Senior Business Analyst, Wellcome Trust Innovations
Timothy Jinks

William Weiss

Director of Pre-Clinical Services, University of North Texas Health Science Center
William Weiss

Conference agenda

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8:30

Registration & Coffee

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9:00

Opening Remarks

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9:15

Creating a target product profile

• Defining what is needed - definition of spectrum, indications and route of administration

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10:15

Pre- clinical work to enable human studies

• What is specific to antimicrobials

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10:45

Morning Coffee

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11:15

Into man and defining the dose, PK/PD and

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11:45

Clinical trials, indications, geographic

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12:15

Closing remarks

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12:30

End of workshop

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13:30

Registration & Coffee

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14:00

Introduction to licensing

• Overview of the licensing process
• Who should be included in the licencing
team

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14:30

Preparing a product dossier format

• What are the key elements and issues
• What big pharma says it wants

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15:00

Afternoon Tea

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15:30

Product evaluation and due diligence

• 4-step process
• Key technical issues to consider

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16:15

Open discussion

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16:30

End of workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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9:10

Do we need new business models for rewarding new antibiotics?

Jorge Mestre-Ferrandiz

Jorge Mestre-Ferrandiz, Director of Consulting, Office of Health Economics (OHE)

• Economic challenges – is there a need for a new business model?
• Incentives – what has worked in the past?
• Addressing the challenges – what could be the new business model?
• On-going initiatives
 

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9:50

DRIVE-AB: An industry perspective

David Findlay

David Findlay, Commercial Director, II-ID Global Franchise, GlaxoSmithkline

• The need for delivery of a new commercial model
• Objectives and structure of DRIVE-AB
• Partnership approach to delivering a new commercial model
• Beyond DRIVE-AB

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10:30

Morning Coffee

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11:00

The changing role of academia in antimicrobial drug discovery

William Weiss

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

• Historical perspective of academic involvement in drug development
• Growth of the modern pharmaceutical industry and detachment from academia
• Downturn in antibacterial discovery and development and current need for increased research capabilities
• Collaboration of industry and academia in drug discovery and development
• Novel partnering models to increase innovation in pharmaceutical R&D

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11:40

Partnering and working with BARDA

Melissa Stundick

Melissa Stundick, Acting Branch Chief, Broad Spectrum Antimicrobials Program, BARDA

• Discuss recent US government initiatives for countering antimicrobial resistance
• Discuss how those initiatives impact BARDA’s future investments
• Understand BARDA’s research priorities and areas of interest
• Learn how BARDA forms partnerships for the development of antibacterial therapies

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12:20

Networking Lunch

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13:20

Thousands of new antibiotic classes: The road to patients

David Williams

David Williams, Chief Executive Officer, Discuva

• New small molecule discovery paradigm
• The use of new technologies
• A novel validated approach to anti-bacterial therap

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14:00

Where have all the bugs gone? Challenges in enrolling resistant pathogen studies

Ian  Friedland

Ian Friedland, Chief Medical Officer, Achaogen, Inc.

• Resistant Gram negative infections are a worldwide threat
• However, challenges to conducting acceptable studies focused on resistant pathogens are numerous
• Development pathways relying on such studies require flexibility
• Potential ways forward are suggested

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14:40

Afternoon Tea

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15:10

PhagoBurn: from cold war to “hot” phage therapy

Jerome  Gabard

Jerome Gabard, CEO, Pherecydes

• The band: Pherecydes Pharma and the French Defence Health Service
• The tune: Phage against MDR E. coli and P. aeruginosa bacteria
• The gear: PhagoBurn, 1st phage therapy multicentre European trial

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15:50

There’s no escape – single target, multiple effects

Colin J Suckling

Colin J Suckling, Research Professor of Chemistry, University of Strathclyde

• A dirty drug to clean up infection?
• Catastrophic failure in a bug
• Chemical mechanism, biological consequence
• Is it safe to target DNA?

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16:30

Prevention is better than cure?

Fiona Marston

Fiona Marston, Chief Executive, Absynth Biologics

• Is there a role for vaccines in the fight against microbial drug resistance?
• Why is it proving difficult to develop a Staph. aureus vaccine?
• A different approach – to improve chances of success
• A platform for other vaccines

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17:10

Panel Discussion: How to de-risk and optimise clinical development of antimicrobials

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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17:40

Chairman’s Closing Remarks and Close of Day One

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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9:10

50 years of frustration. What have we learned? What can we do to escape from this nightmare?

Domingo  Gargallo-Viola

Domingo Gargallo-Viola, Chief Scientific Officer, ABAC Therapeutics

• Despite the enormous efforts in industry research for discovering broad-spectrum antibacterials with new mechanisms of action, the newest molecular mechanism of action is 50 years old. What can we do to provide solutions to this dangerous fact?
• Attrition is a major issue in drug discovery and development, making the drug development process enormously inefficient and costly. Can we be more successful?
• The business opportunities in infectious diseases, necessarily go through a radical paradigm shift and high doses of disruptive innovation.
• To improve productivity and delivery, it is necessary to review topics such as: target product profile, drug discovery strategy and collaborations

 

 

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9:50

Novel inhibitors of topoisomerases for drug-resistant bacteria

Neil Stokes

Neil Stokes, Head of Biology, Redx Anti-Infectives

• Strategies for new antibacterial discovery
• Gram-positive inhibitors with potent activity against MRSA
• Broad-spectrum agents for MDR Gram-negatives
• Innovative partnerships in antibiotic development
 

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10:30

Morning Coffee

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11:00

Debio1450: Another drug against Staphylococci?

Frederick  Wittke

Frederick Wittke, Medical Director , Debiopharm International

• Description of the mechanism of action of a new antibiotic with narrow specificity
• To understand the impact of antibiotics on the human microbiome
• Understand the current status of development of Debio1450
 

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11:40

MGB Biopharma: Bringing True Novelty to the Anti-Infective Space

Dawn Firmin

Dawn Firmin, Head of Project Management , MGB Biopharma

• New class of anti-infectives for the treatment of C. difficile infections
• Efficacy: MGB-BP-3 v’s gold standard
• Benefits to NHS and patients
• Use in line with antibiotic stewardship to combat resistance

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12:20

Networking Lunch

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13:20

Anti-gram-negative drug discovery: A humbling test of perseverance

Ryan  Cirz

Ryan Cirz, Director of Biology , Achaogen

• What to target (and how that reveals the limitations of our scientific creativity)
• Why is it so difficult to find the right chemistry and achieve potency?
• Key challenges in translation

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14:00

Panel Discussion: How to best ensure a reliable pipeline of appropriate drugs?

Richard Bax

Richard Bax, Senior Partner, TranScrip Partners

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14:40

Afternoon Tea

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15:10

Antibiotics and their alternatives – fixing and feeding the pipeline

Patricia  Paukovits

Patricia Paukovits, Scientific Officer, European Commision

 

       Research strategy and actions
       Collaboration across countries, sectors and disciplines
       New funding instruments
  • Horizon Prize for better use of Antibiotics
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    15:50

    Antibiotics and their alternatives –Is there a need for innovative finance?

    Stefan Acsinte

    Stefan Acsinte, Legal Counsel, European Investment Bank

    • EIB’s financing mechanisms supporting R&D investments
    • Overview of InnovFin Programme under Horizon 2020

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    16:30

    Wellcome Trust funding opportunities

    Timothy Jinks

    Timothy Jinks, Senior Business Analyst, Wellcome Trust Innovations

    •       Introducing Wellcome Trust Innovations – What is our mission? 
    •       How we are seeking innovative therapeutics and diagnostics to transform the treatment of infectious diseases
    •       Examples of success
    •       The selection process and a view of the investment selection criteria

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    17:10

    Chairman’s Closing Remarks and Close of Day Two

    Richard Bax

    Richard Bax, Senior Partner, TranScrip Partners


    Research Professor of Chemistry
    University of Strathclyde
    Commercial Director, II-ID Global Franchise
    GlaxoSmithkline
    Licensing & Business Development Consultant
    PharmaConsulting
    Professor of Chemistry
    Cambridge University
    Chief Executive Officer
    Discuva
    Head of Project Management
    MGB Biopharma
    Chief Scientific Officer
    ABAC Therapeutics
    Chief Executive
    Absynth Biologics
    Medical Director
    Debiopharm International
    Chief Medical Officer
    Achaogen, Inc.
    CEO
    Pherecydes
    Director of Consulting
    Office of Health Economics (OHE)
    Acting Branch Chief, Broad Spectrum Antimicrobials Program
    BARDA
    Head of Biology
    Redx Anti-Infectives
    Scientific Officer
    European Commision
    Senior Partner
    TranScrip Partners
    Director General
    EFPIA
    Director of Biology
    Achaogen
    Senior Business Analyst
    Wellcome Trust Innovations
    Director of Pre-Clinical Services
    University of North Texas Health Science Center

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    Workshops

    Interview with Jerome Gabard, CEO, Phercydes

    Download

    Q&A with Keith William, Director and Consultant, KW Drug Developments Ltd & Boyd Consultants

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    Superbugs & Superdrugs 2015 | Is your name on the list?

    Download

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    SCRIP Intelligence is the leading source of news and strategic analysis for the global pharmaceutical industry. We filter the flood of information on the industry and apply the knowledge of our extensive network of analysts, journalists and key opinion leaders to provide our readers with timely business-critical market and competitor intelligence.


    World Pharma Today

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    http://www.worldpharmatoday.com



    Biosave

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    http://www.Biosave.com

    Biosave.com brings together the best Life Science promotions, product releases, featured products, publications, videos and events from 100’s of leading Life Science suppliers. Updated 24 hours a day, Biosave is constantly uploading special promotions and exciting product news that you won’t find anywhere else. Our goal is to provide our users with the most exclusive product information to help reach that all important purchasing decision.


    pharmaphorum

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    http://www.pharmaphorum.com

    pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com


    International Pharmaceutical Industry

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    http://www.ipimediaworld.com

    IPI gives you an insight into all areas of Biopharm, Medical, Pharmaceutical and Healthcare. IPI provides a proven supportive means of communication to the Pharmaceutical, Bio Pharmaceutical, Nutraceutical and Medical Devices industry, incorporating the latest in research and technology innovations, regulatory guidelines, marketing and communication strategies.


    Pharmaceutical Technology

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    http://www.pharmaceutical-technology.com

    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.


    Pharma Technology Focus

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    http://www.nridigital.com/

    Pharma Technology Focus Magazine is a dynamic bi-monthly online publication available on iPad and online. It offers in-depth coverage of the most important issues and the latest developments in the pharmaceutical industry, in an innovative digital format. Brought to you by an experienced editorial and design team, Pharma Technology Focus is the essential magazine for decision-makers wanting up-to-date pharmaceutical industry news and analysis, with articles and features covering technology, discovery and development, packaging and labelling, supply chains, manufacturing and ingredients, trials and successes and much more.


    Pharmiweb

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    http://www.pharmiweb.com

    Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector’s most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.


    Mednous

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    http://www.MedNous.com

    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com

    Holiday Inn Regents Park

    Carburton Street
    London W1W 5EE
    United Kingdom

    Holiday Inn Regents Park

    Choose the well-connected Holiday Inn London-Regent's Park hotel, with a superb central London location and speedy transport links. Holiday Inn London-Regent's Park is in a leafy and cosmopolitan area of central London, a 10-minute walk from bustling Oxford Street. Leave your car in our NCP managed underground car park, and explore London by Tube. Great Portland Street Tube station is 25 metres from the hotel, from where you can reach the City and Canary Wharf in 30 minutes, and London Heathrow Airport in 45 minutes.

    Wireless Internet is available throughout the hotel, and you can invite up to 300 people to events at the Academy Conference Centre, with an IT technician and break-out zones. Holiday Inn London-Regent's Park is a 10-minute walk from Santander's offices and businesses in the BT Tower. Stroll 5 minutes to Regent's Park, where you'll find London Zoo and pretty Primrose Hill. We're a 10-minute walk from Bond Street boutiques and 20 minutes from Buckingham Palace and cruises on the River Thames.

    Ask our Concierge to plan your day out and book West End theatre tickets. Room Service is available 24 hours at Holiday Inn London-Regent's Park, or dine in the vibrant Junction Restaurant. Our Junction Bar has a menu of light bites, and a hot breakfast buffet is served daily.

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
    Registered in England - SMi Group Ltd trading as SAE Media Group




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