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Stem Cells: Drug Discovery and Therapeutics
16 February - 17 February 2009
Stem Cells:  Drug Discovery and Therapeutics

16th to 17th February 2009, Crowne Plaza Hotel - St James, London, United Kingdom.

The development of stem cells for therapeutic purposes, including cell therapy and regenerative medicine, is emerging as a major field of pharmaceutical research. Stem-cell technology is also making inroads in drug discovery. This technology offers great potential for understanding disease mechanisms and identifying targets, and for effective toxicology screening.

This conference addresses both therapeutic and non-therapeutic stem-cell applications. For companies engaged in cell-therapeutics, the technical aspects of achieving stable stem cell populations, as well as product manufacturing challenges and logistics are addressed.  Large pharma are increasingly turning to stem cells to identify targets for drug development and for toxicology testing.  Also, they are looking to partner with smaller biotech firms to develop commercially viable regenerative medicine products.  Networking and presentations by both will foster this relationship.

Experts in stem cell science and applications, as well as policy and bio-business come together to cover the emerging role of stem cells in drug development and therapy.   As stem cell science matures, it becomes clear that supply and technology will soon cease to limit product development, and that pharmaceutical companies engaged with stem cells will have a competitive advantage.  For those who share this attitude, this is a must-attend event.

  • Diane Harbison, Associate Director, Pfizer
  • Alain Vertes, Global Alliance Director, Roche
  • Thomas Okarma, CEO, Geron
  • Ian Wilmut, Chair of Reproductive Biology, Director, Scottish Centre for Regenerative Medicine
  • Elizabeth Hill, Director, Head of Transactions, Cambridge Consultants Ltd
  • Gabriel Markson, Lead Analyst Cell Therapy, Cambridge Consultants Ltd
     
     

Conference agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

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9:10

Overview on stem cell based predictive assays

Nicole zur Nieden

Nicole zur Nieden, Research Group Leader , Fraunhofer Institute For Cell Therapy & Immunology

  • Stem cells for toxicity testing – an overview
  • Comparing stem cell assays with other in vitro models
  • Caveats and recent improvements of stem cell assays
  • Legislation, regulation
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10:00

Best Practice

Nicole zur Nieden

Nicole zur Nieden, Research Group Leader , Fraunhofer Institute For Cell Therapy & Immunology

  • choice of cell species
  • standardization of stem cell culture
  • pluripotency
  • serum-free versus serum-containing cultures
  • choosing an assay endpoint
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10:50

Morning Coffee and Poster Viewing

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11:20

Discussion

Nicole zur Nieden

Nicole zur Nieden, Research Group Leader , Fraunhofer Institute For Cell Therapy & Immunology

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12:10

Summary

Nicole zur Nieden

Nicole zur Nieden, Research Group Leader , Fraunhofer Institute For Cell Therapy & Immunology

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12:30

Close of Workshop

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Tim Allsopp

Tim Allsopp, Chief Scientific Officer, Stem Cell Sciences

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9:10

KEYNOTE SESSION: HUMAN EMBRYONIC STEM CELL THERAPIES

Tom Okarma

Tom Okarma, Chief Executive Officer, Geron

  • Geron Corporation will be the first to bring human embryonic stem cell therapies to the clinic
  • Content of Geron’s GRNOPC1 IND
  • The application to the FDA seeking permission to study hESC-derived oligodendroglial progenitor cells in patients with subacute spinal cord injury
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    9:45

    HOW TO BOOST STEM CELL NUMBERS IN THE BLOOD

    Sara Rankin

    Sara Rankin, Reader in Leukocyte and Stem Cell Biology, National Heart & Lung Institute, Imperial College

  • For many years haematologists have used G-CSF to mobilize haematopoietic stem cells (HPCs) from bone marrow
  • Recently the CXCR4 antagonist Mozobil has been shown to mobilize HPCs, acting synergistically with G-CSF
  • We show that other distinct populations of bone marrow stem cells, endothelial progenitors and mesenchymal stem cells that promote tissue repair are mobilized by a combination of VEGF and Mozobil. This drug therapy does not mobilize HPCs
  • The molecular mechanisms underlying the differential mobilization of these stem cell populations will be discussed
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    10:20

    STANDARDIZATION OF STEM CELL CULTURING

    Judit Nagy

    Judit Nagy, Research Scientist, Director Proteomics Facility, Imperial College

  • Serum free culture media
  • Starting material
  • Reproducible end product
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    10:55

    Morning Coffee

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    11:25

    STEM CELL BASED SYSTEMS IN REPRODUCTIVE TOXICOLOGY

    Karim Nayernia

    Karim Nayernia, Chair of Stem Cell Biology, North East England Stem Cell Institute

  • ESCs as an innovative alternative for early efficacy and reproductive toxicity screening
  • Advantages and limitations of this system
  • Combining stem cell technology and microarray techniques to understand reproductive toxicants
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    12:00

    STEM CELLS FOR REGENERATIVE MEDICINE; SCALABLE PLATFORM TECHNOLOGIES

    Thorsten Gorba

    Thorsten Gorba, Research Team Leader, Stem Cell Sciences

  • Why robust scaling is important
  • Stem cell based assays and screens
  • Can tissues be regenerated or reprogrammed from within?
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    12:35

    A HIGH CONTENT ANALYSIS APPROACH TO STEM CELL RESEARCH

    Neil Durso

    Neil Durso, Field Application Scientist, Thermo Scientific Cellomics High Content Analysis Technologies, Thermo Fisher Scientific

  • High Content Analysis (HCA) is an emergent technology that is now established in many different areas of research
  • The capacity of HCA to make multiple quantitative cell-by-cell measurements coupled with the ability to specifically define targeted cellular populations makes it a powerful tool for understanding the signaling processes, differentiation and physiology of stem cells
  • A High Content approach can lead to greater productivity and accelerated research in this key biological area
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    13:15

    Networking Lunch

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    14:15

    KEYNOTE SESSION: REPROGRAMMING iPS CELLS

    Sir Ian Wilmut

    Sir Ian Wilmut, Director, Scottish Centre for Regenerative Medicine

  • Derivation successes and selection strategies
  • Comparing properties of iPS with ESCs
  • Applying iPS technology to unmodified cells
  • Application of iPS technology in disease therapies
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    14:50

    STEM CELLS IN TRANSLATIONAL MEDICINE

    Rajesh Chopra

    Rajesh Chopra, Global Medical Science Director and Senior Principal Scientist, AstraZeneca

  • Pharma's perspective on therapeutic products from stem cells
  • Business development potential
  • Combination products
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    15:25

    STEM CELLS IN PREDICTIVE TOXICOLOGY

    Louise Leong

    Louise Leong, Science Director, SC4SM, Stem Cells for Safer Medicine

  • SC4SM - A public private partnership
  • Drivers in drug safety evaluation
  • Research programme and future direction
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    16:00

    Afternoon Tea

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    16:30

    EMBRYONIC STEM CELL-DERIVED NEURONS AS A CELLULAR MODEL FOR DRUG DISCOVERY

    Miriam Bibel

    Miriam Bibel, Senior Research Investigator, Novartis

  • Technological advances in neuronal differentiation methods
  • Target identification and validation
  • Pharmacological screening
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    17:05

    CANCER STEM CELLS

    Dominique Bonnet

    Dominique Bonnet, Senior Group Leader, Cancer Research UK

  • Identification
  • Characterisation
  • New therapeutic targets
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    17:40

    Chairman’s Closing Remarks and Close of Day One

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Diane Harbison

    Diane Harbison, Associate Director, Pfizer Global Research and Development

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    9:10

    PARTNERING WITH BIOTECH

    Esteban Pombo Villar

    Esteban Pombo Villar, Head of Strategic Alliances, Novartis Institute of Biomedical Research

  • Opportunities
  • Evaluating and mitigating risk
  • New R&D paradigms
  • Licensing
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    9:45

    EVALUATING EMERGING TECHNOLOGIES

    Alain Vertes

    Alain Vertes, Global Alliance Director, Roche Pharmaceuticals

  • Cultural fit with pharmas
  • Strategic vision
  • Implementation

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    10:20

    Morning Coffee

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    10:40

    MAKING YOUR NEW PARTNERSHIP WORK

    Rob Hockney

    Rob Hockney, Chief Executive, Partnering Excellence

    • Identify some of the challenges you’ll need to overcome if you’re to realise the greatest possible value from your new partnership.
    • Avoiding the pitfalls that can corrode partnerships
    • Tools and approaches which help maximise the success
    • The importance of a "collaborative mindset"
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    11:15

    HOW TO COMMERCIALISE CELL THERAPY

  • Is the cell therapy business viable - global examples and case studies
  • How to commercialise a cell therapy product
  • The emerging cell therapy markets and opportunities
  • Elizabeth Hill

    Elizabeth Hill, Director, Head of Transactions, Cambridge Consultants

    Gabriel Markson

    Gabriel Markson, Lead Analyst Cell Therapy, Cambridge Consultants Ltd

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    11:55

    DEVELOPING REGENERATIVE MEDICINE IN PHARMA

    Diane Harbison

    Diane Harbison, Associate Director, Pfizer Global Research and Development

  • Pfizer’s approach to an integrated regenerative medicine unit
  • Utilizing existing collaborations
  • Resource management
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    12:30

    Networking Lunch

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    13:30

    PROSPECTS IN CELL TRANSPLANTATION: TREATING DIABETES

    Ole Madsen

    Ole Madsen, Director of Research, Novo Nordisk

  • molecular processes controlling pancreas ontogeny
  • ex vivo/in vivo expansion of a functional ß-cell mass
  • transplant treatment of insulin-dependent diabetes mellitus
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    14:05

    PATENTABILITY OF STEM CELLS IN EUROPE

    Aliki Nichogiannopoulou

    Aliki Nichogiannopoulou, Principle Examiner Biotechnology / Patent Law, European Patent Office

  • Awaiting speaker bullet points
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    14:40

    INVESTING IN STEM CELL TECHNOLOGY

    Cathy Prescott

    Cathy Prescott, Director, Biolatris

  • The three major business models that encompass the regenerative medicine sector
  • Typical funding levels required and potential sources of funding
  • Challenges and opportunities faced by each company-type in the context of pharma industry trends and current venture investment
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    15:15

    Afternoon Tea

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    15:35

    STEM CELLS FOR DRUG SCREENING AND TOXICITY TESTING

    Chikafumi Yokoyama

    Chikafumi Yokoyama, CEO, ReproCELL

  • QT prolongation by using ES-derived beating cardiomyocyte
  • ES-derived disease model cells
  • Japanese National Project of human ES cells
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    16:10

    THE REGULATION OF STEM CELL PRODUCTS

    Julian Hitchcock

    Julian Hitchcock, Senior Solicitor Life Sciences, Mills & Reeve Solicitors

  • The changing patent landscape in stem cells
  • The ATMP regulation
  • Regulation of manufacture
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    16:45

    IDENTIFYING THE STEM CELL NICHE AND TRACING CELL LINEAGES IN HUMAN TISSUES

    Malcolm Alison

    Malcolm Alison, Professor of Stem Cell Biology, Barts & The London

  • Clonal populations of cells can be identified by identical defects in the mtDNA gene encoding cytochrome c oxidase
  • Stem cell niches have been identified at the base of colonic crypts, in the periportal area of the liver and in the pancreatic ducts
  • The origin of a common skin cancer, basal cell carcinoma, has been traced to the outer root sheath of the hair follicle
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    17:20

    Chairman’s Closing Remarks and Close of Conference

    Workshops

    Practical considerations for stem cell based predictive assays

    Practical considerations for stem cell based predictive assays

    Crowne Plaza Hotel - St James
    18 February 2009
    London, United Kingdom

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51
    London SW1E 6AF
    United Kingdom

    Crowne Plaza Hotel - St James

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    WHAT IS CPD?

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