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Anti-infective Drug Discovery and Development Workshop: Translating Innovation to Success
17 March 2009
Anti-infective Drug Discovery and Development Workshop: Translating Innovation to Success

For any company involved in discovering and developing anti-infectives, successful and efficient pre-clincial development is vital. This workshop, presented by Nafsika Georgopapadakou of NovaBay Pharmaceuticals, will focus on the entire translational process, from strategy and planning, through target discovery and selection, to in vitro and in vivo testing of a new chemical entity. This interactive workshop will provide a great opportunity to gain insights and improve your drug development programmes.

About your workshop leader:

Nafsika Georgopapadakou is Vice President of Research at NovaBay Pharmceuticals based in Emeryville, CA. In the past twenty years, she has held positions of increasing responsibility in drug discovery at Bristol-Myers Squibb, Roche, DuPont Pharmaceuticals, NewBiotics and Methylgene.

About the organisation:

NovaBay Pharmaceuticals is focused on developing innovative product candidates targeting the treatment or prevention of a wide range of infections in hospital and community environments

Workshop agenda

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13:30

Registration & Coffee

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14:00

Welcome and Introductions

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14:00

Introduction: The tale of two anti-infectives

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14:10

Strategies & tactics

  • Approaches: innovation v. in-licensing
  • Where to start: depends on strengths
  • The good-and-bad news:  resistance!
  • The importance of staying focused but alert to new developments

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    14:30

    Target selection & antimicrobial spectrum

  • A priori criteria for anti-infective targets
  • Can a drug be a target?
  • Antimicrobial spectrum and indications
  • Community v. hospital-acquired infections
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    14:50

    In-vitro testing: mechanism of action, cidal/static, resistance; effect of serum on activity; mammalian cytotoxicity

  • Mechanism of action
  • Cidal/static, post-antibiotic effect
  • Resistance: spontaneous, cross
  • Effect of serum on activity
  • Mammalian cytotoxicity:  tissue culture, biochemical panels
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    15:30

    Animal Studies

  • Choosing the right animal model
  • Acute toxicity
  • Efficacy
  • PK/PD
  • Streamlining dosage based on PK/PD
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    16:10

    Summary, questions, discussion

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    16:40

    Close of Workshop

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51
    London SW1E 6AF
    United Kingdom

    Crowne Plaza Hotel - St James

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

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    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

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    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

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