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Pain Therapeutics (Virtual Conference)
10 May - 11 May 2021

Post event on demand access to recorded presentations will be available to all attendees 5 working days from the end date of the event.

Pain Therapeutics (Virtual Conference)

SAE Media Group is proud to present the 21st Annual Pain Therapeutics Virtual Conference on 10th and 11th May 2021.

The global Postoperative Pain Therapeutics Market was valued at USD 11.26 Million in 2018 and is projected to reach USD 15.87 Million by 2026, growing at a CAGR of 4.40 % from 2019 to 2026. Chronic pain is a major health care problem that affects some 30%-50% of the world population and almost 20% of Europeans suffer from chronic or intermittent pain; the latter results in suffering and disability for patients and increasing economic loss for society.

The 21st Annual Conference will provide insights into cutting edge drug discovery science, preclinical development trends and will explore novel pain drug targets and novel biomarkers. Join Europe's leading Pain Therapeutics Conference which will analyse the latest developments in the field of pain drug development and learn how to industry is working to overcome the challenges of opioid base treatment.
 

sponsors

Conference agenda

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10:00

Chairman's Opening Remarks

Michael Scherz, Founder & CEO, Metys Pharmaceuticals Ltd

Naheed Mirza, Director of Neuroscience Drug Discovery, Consultant, Sygnature Discovery

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10:10

Update: Demonstration of significant pain relief in subjects with painful osteoarthritis of the knee with a novel anti NGF, anti-TNFa bispecific fusion protein

Iain Chessell, Global Head, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, AstraZeneca

• A bispecific fusion construct shows synergistic efficacy in preclinical models of pain
• We have advanced this molecule into PhI clinical development in osteoarthritis pain patients
• Preliminary data demonstrates dose dependent and statistically significant efficacy after a single dose
• We will also report on preliminary efficacy data
 

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10:40

Therapeutic novelties signifying a paradigm shift in migraine prevention

Dalma Sugar

Dalma Sugar, Medical Affairs Director, Teva Pharmaceuticals

  • Why is management of migraine critical?
  • What are the major progresses in migraine preventive therapies?
  • Exploring the pathophysiology, targeted pathways and understanding the role of neuropeptides
  • Biomarkers. The potential for future studies on identification of biomarkers that can predict treatment response
  •  

     

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    11:10

    Morning Break and Virtual Exhibit Hall Open

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    11:40

    Botulinum neurotoxin for pain management

    Mikhail Kalinichev, Director, in vivo Neurology, Ipsen

    • Highlighting recent findings on the effects of BoNTs in animal pain models
    • Investigating the effects of BoNT/A on neuropathic pain
    • Can these extremely poisonous molecules can become useful therapeutic agents in a number of expanding applications in human medicine?
    • Progress of BoNT/A for treatment of pain in various types of headache and migraine conditions
     

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    12:10

    Novel Targets in Pain: Sigma 1

    Naheed Mirza, Director of Neuroscience Drug Discovery, Consultant, Sygnature Discovery

    • Introduction to Sigma1 proteins
    • Emerging Preclinical and Clinical data on novel Sigma1 molecules
    • Opportunities and Challenges in prosecuting Sigma1
     

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    12:40

    The Potential Role of the Type 3 Adenosine Receptor Modulators

    Joseph V. Pergolizzi, Chief R&D Officer , Neumentum

    • Examine the adenosine receptors system
    • Define the potential Moa related to analgesia
    • Explore a novel aRM3 nTM-006 existing data

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    13:10

    Networking Break and Virtual Exhibit Hall Open

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    14:10

    The NIH HEAL initiative: efforts to enhance pain management through therapy development programs

    Smriti Iyengar, Director, PSPP, Program Director, NINDS, NINDS/NIH

    • Accelerate the discovery and development of non-opioid, non-addictive therapeutics through preclinical and clinical therapy development programs in NINDS
    • Rigor and reproducibility as guiding principles
    • Multiple modalities including small molecules, biologics, devices and natural products are within scope
    • Opportunities for academic and industry asset owners worldwide
     

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    14:40

    Expanding advantages and insights with new porcine models

    Sigal Meilin

    Sigal Meilin, Chief Scientific Officer, MD Biosciences

    Expanding advantages and insights with new porcine models

  • Employing porcine models in the study of pain. Why pigs?
  • Differences and applications of Minipigs and domestic pigs
  • Sex differences in withdrawal response and outcome
  • IENF Differences in male and female, non-operated pigs
  • Future development plans
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    15:20

    Spotlight Session: Exploring the expansion of pain research at the National Institutes of Health

    David A. Thomas, Senior Advisor to the Director, National Institutes of Health

    • Focussing on the need to consider race as a variable in pain research and therapeutic development
    • Discussing the bias against those experiencing pain in pain research and pain treatment
    • Defining racial and ethnic disparities in pain management
    • Highlighting the need for greater pain education to overcome such bias

     

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    15:50

    The Bunionectomy Model in Acute Postoperative Pain Trials

    Neil Singla, Chief Scientific Officer, Lotus Clinical Research, LLC

  • Why is bunionectomy popular in pharmaceutical pain research
  • How and why was the model developed
  • What are the experimental characteristics of the model
  • Where does the model predict/ fail to predict clinical results
  • How can clinicians relate bunionectomy data to surgeries they most often practice
  •  

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    16:30

    Afternoon Break and Virtual Exhibit Hall Open

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    17:00

    Panel: Seeking funding for pain clinical research trials

    • Which organisations in Europe can provide funding for research and development of drugs for pain relief?
    • What recommendations can the larger pharmaceutical companies give the small biotech companies in terms of seeking funding for clinical trials?
    • Where is funding most needed?
    • Strategies to generate more funding into pain research to eliminate the issue of underfunding
     

    Michael Scherz, Founder & CEO, Metys Pharmaceuticals Ltd

    Smriti Iyengar, Director, PSPP, Program Director, NINDS, NINDS/NIH

    David A. Thomas, Senior Advisor to the Director, National Institutes of Health

    Tina Doshi, Assistant Professor of Pain Medicine, Johns Hopkins University

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    17:35

    Diversity matters: The importance of sex and gender in pain research

    Tina Doshi, Assistant Professor of Pain Medicine, Johns Hopkins University

    • Identify sex and gender differences in pain, including biomarkers, molecular targets, clinical and experimental models of pain
    • Recognize gender gaps in pain patient treatment and among pain clinicians
    • Understand the benefits of diversity among pain researchers and clinicians as important steps for developing personalized pain care
    • Discuss strategies for improving diversity in pain medicine
     

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    18:05

    Biomarker use in Pain Clinical Studies: Where have we been and where should we go?

    Richard Malamut, Chief Medical Officer and EVP, Collegium Pharmaceuticals

    • Identifying the role of biomarkers to evaluate target engagement of new drugs and predict the analgesic efficacy of new drugs
    • Discussing progress, challenges and gaps to facilitate the development of biomarkers
    • Highlighting the importance of biomarker discovery and its contribution to early stage studies on pain
    • Reflecting on ideas to stimulate research and technology development in this area of high unmet medical need
     

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    18:35

    Chairs’ Closing Remarks and Close of Day One

    Naheed Mirza, Director of Neuroscience Drug Discovery, Consultant, Sygnature Discovery

    Michael Scherz

    Michael Scherz, Founder & CEO, Metys Pharmaceuticals Ltd

    clock

    10:00

    Chairman's Opening Remarks

    Michael Scherz, Founder & CEO, Metys Pharmaceuticals Ltd

    Naheed Mirza, Director of Neuroscience Drug Discovery, Consultant, Sygnature Discovery

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    10:10

    Phase 2 clinical trial results of racemic dimiracetam for the treatment of antiretroviral treatment-related neuropathic pain: lessons for the Phase 2 clinical trial of MP-101, a non-racemic mixture of the dimiracetam enantiomers

    • A failed Phase 2 trial by dimiracetam's previous Sponsor
    • A post-hoc PK-based analysis; a second post-hoc PK-based analysis
    • A safety assessment
    • A few lessons we've applied to our plans for MP-101, a patented non-racemic mixture of the dimiracetam enantiomers
     

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    10:40

    Development of a novel non-drowsy skeletal muscle relaxant: What is the current unmet medical need?

    Randall Kaye, Chief Medical Officer, Neurana Pharmaceuticals

    • Discussing the mechanisms of Tolperisone and its applications in pain relief
    • How can Tolperisone help treat acute back spasms without causing drowsiness?
    • Exploring Tolperisone as the first muscle relaxant for the treatment of symptoms associated with acute and painful muscle spasms of the back
    • Presenting Neurana’s work in developing an ultra-pure formulation of Tolperisone, not available in other countries that has a lower degradant yield and meets ICH guidance
     

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    11:10

    Morning Break and Virtual Exhibit Hall Open

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    11:40

    CLE-400 - a novel non-opioid topical treatment for painful peripheral diabetic neuropathy

    Orna Goren

    Orna Goren, Products Cluster leader, Clexio Biosciences

  • Introduction to CLE-400 and its multi-modal mechanism of action
  • The skin as the target: maximizing skin penetration and creating a depot effect, while limiting systemic exposure.
  • Discussing CLE-400 rapid onset of effect and cumulative analgesic effect observed in different pharmacological models 
  • Discussing emerging phase I data on CLE-400
  • clock

    12:10

    AP-325 as a novel, non-opioid treatment for neuropathic pain

    Guido Koopmans, CSO, Algiax Pharmaceuticals Gmbh

    • Introduction to AP-325
    • Discussing emerging preclinical and phase I data on novel AP-325
    • How can AP-325 aid towards the treatment of chronic neuropathic pain without causing serious side-effects on the central nervous system?
    • Exploring AP-325 as an important approach in the fight against the opiate crisis
     

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    12:40

    Panel: Rethinking pain clinical trials during the COVID-19 pandemic

    • Overview of current pain clinical trials taking place
    • How has COVID-19 changed the experience in which we approach data verification, data analysation and data collection?
    • How are patients managed differently in clinical trials during this period?
    • How has COVID-19 presented an opportunity to reform the way we conduct clinical trials moving forward?
    • How have we adapted to change and remained flexible during the era of COVID-19?
     

    Achim Kless, Pain Genetics Lead, Eli Lilly & Company

    Guido Koopmans, CSO, Algiax Pharmaceuticals Gmbh

    Randall Kaye, Chief Medical Officer, Neurana Pharmaceuticals

    Joseph V. Pergolizzi, Chief R&D Officer , Neumentum

    Iain Chessell, Global Head, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, AstraZeneca

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    13:15

    Networking Break and Virtual Exhibit Hall Open

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    14:15

    Deep Dive: Exploring Novaremed’s work in developing NRD.E1, an innovative therapy for diabetic neuropathic pain

    Sara Mangialaio, CMO, Head of R&D, Novaremed

    • Discussing Novaremed’s lead drug, NRD.E1 as a non-opioid small molecule for the treatment of neuropathic pain
    • Analysing the results from a proof of concept study
    • Understanding the potential of NRD.E1 in addressing a major unmet medical need in diabetic neuropathic pain
     

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    14:45

    Exploring genetics in common pain diseases

    Luda Diatchenko, Professor, McGill University

    • Common genetic variants as markers for analgesic responses
    • Common genetic variants in pain target discovery
    • Use of common genetic variants diseases for reconstructing pathophysiology of chronic pain
     

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    15:15

    Covalent and non-covalent TRPA1 agonists exert distinct ligand-binding and pain mechanisms

    Jun Chen, Senior Scientist, Genentech

    • Reporting the discovery of a non-covalent agonist, GNE551 and determining a cryo-EM structure of the TRPA1-GNE551 complex
    • Understanding how GNE551 activates TRPA1 into a distinct conducting state without desensitization and induces persistent pain
    • Exploring how GNE551-evoked pain is relatively insensitive to antagonist treatment
    • Demonstrating the biased agonism of TRPA1, a finding that has important implications for the discovery of effective drugs tailored to different disease
     

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    15:45

    Afternoon Break and Virtual Exhibit Hall Open

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    16:15

    Exploring pain genetics in rare diseases

    Achim Kless, Pain Genetics Lead, Eli Lilly & Company

    • From GWAS results to novel pain targets
    • Exploring rare variants in pain target discovery
    • Pain phenotypes across traits
    • Future of drug development for rare diseases
     

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    16:45

    An overview of volatile anaesthetics and their applications in pain therapeutics

    Heather Giles, CEO and Chief Scientific Officer, Vapogenix

    • Discussing how volatile anaesthetics can alleviate pain
    • Exploring how volatile anaesthetics (VAs) can treat inflammatory pain associated with musculoskeletal diseases such as rheumatoid arthritis, gout and osteoarthritis
    • To what extent can volatile anaesthetics be considered as an effective alternative to opioids?
    • What is the future of volatile anaesthetics within pain therapeutics?
     

    clock

    17:15

    Long-lasting Analgesia via Repression of NaV1.7 using CRISPR-dCas9 and Zinc-Finger Proteins

    Ana Moreno, CEO, Navega Therapeutics

    • DNA-level repression of key genes responsible for pain transmission holds great therapeutic potential
    • Discussing future applications of epigenome regulation to treat pain using CRISPR-dCas9 and Zinc-Finger proteins.
    • Demonstrate the efficacy of this approach to prevent and treat neuropathic preclinical pain models
    • Demonstrate preliminary safety results of this approach.
     

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    17:45

    Chairs’ Closing Remarks and Close of Day Two

    Naheed Mirza, Director of Neuroscience Drug Discovery, Consultant, Sygnature Discovery

    Michael Scherz, Founder & CEO, Metys Pharmaceuticals Ltd

    Sponsors

    Exhibitors

    Official Media Partner

    Supporters

    Speaker Interview with Dalma Sugar, Teva Pharmaceuticals

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    Pain Therapeutics 2021 Preliminiary Attendee List

    Download

    Speaker Interview with Joseph V. Pergolizzi, Neumentum

    Download

    Chair Interview - Naheed (Max) Mirza, Sygnature Discovery

    Download

    Speaker Interview with Sigal Meilin, MD Biosciences

    Download

    Speaker Interview with Guido Koopmans, Algiax Pharmaceuticals Gmbh

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    Speaker Interview with Achim Kless, Eli Lilly & Company

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    Speaker Interview with Randall Kaye, Neurana Pharmaceuticals

    Download

    Co-Chairs Invite Letter to Pain Therapeutics Conference

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    Pain Therapeutics 2021 Brochure

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    Pain Therapeutics 2021 Long Programme

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    Pain Therapeutics 2021 Short Programme

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    2021 Chair and Speaker Biographies

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    Past Attendees - Pain Therapeutics

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    Past Speaker Presentation - Vifor Pharma

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    Past Speaker Presentation - University College London

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    Past Speaker Presentation - Teva Pharmaceuticals

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    Past Speaker Presentation - Pain Alliance Europe

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    Past Speaker Presentation - Pierre Fabre Research Institute

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    Past Speaker Presentation - Collegium

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    Sponsors


    Lotus Clinical Research

    Sponsors
    http://www.lotuscr.com/

    Lotus Clinical Research is a full-service CRO, research site network and regulatory consulting firm specializing in analgesic and CNS indications. Lotus offers robust CRO infrastructure, program-wide scientific support, and extensive operational expertise in a complete turnkey solution for clients.


    MD Biosciences

    Sponsors
    https://www.mdbneuro.com

    MD Biosciences Neuro is a preclinical and translational contract research organization (CRO) offering services for drug development in the field of neurology and pain research. We understand that finding a trust-worthy preclinical partner is a top priority for drug developers and believe that you should have confidence in the partner you choose. That's why we are dedicated to providing each client valued expertise and advice, experience for flawless execution, and flexibility to meet the needs of rapidly changing requirements.

    With a presence in the innovation hubs of Cambridge, Massachusetts and with state of the art laboratories in Israel, our team is dedicated to building collaborative programs and creating lasting partnerships in the biotechnology community.


    Exhibitors


    Transpharmation

    Exhibitors
    http://www. transpharmation.co.uk

    Transpharmation is a preclinical CRO led by scientists. Building on the founders' international reputation and CNS drug discovery expertise, Transpharmation's global client base benefit from decades of experience in preclinical translational neuroscience, including pain & inflammation, EEG, cognition, epilepsy, neurodegeneration and anxiety/mood disorders, together with a biomarker platform.

    Media Partners


    ACNR

    Official Media Partner
    http://www.acnr.co.uk

    ACNR (Advances in Clinical Neuroscience & Rehabilitation) is one of the most widely read publications in the neurology field in the UK. It provides concise review articles, specialist reviews of core papers from international journals, conference news, book reviews, short accounts of best management practice, case reports, news of awards/appointments and more. This independently produced journal is available free of charge to members of the profession, and we welcome your input.


    The British Journal of Pain

    Official Media Partner
    http://bjp.sagepub.com/

    The British Journal of Pain is the official journal of the British Pain Society. It provides scientists and clinicians in pain medicine with peer-reviewed review articles and expert opinions on all aspects of pain management from basic science to its clinical application including pain physiology, pharmacology and interventions. This journal provides content of multidisciplinary interest and reviews and forecasts important issues and trends in the management of acute and chronic pain.


    Pain News

    Official Media Partner
    https://www.britishpainsociety.org/pain-news-1/

    The British Pain Society Newsletter Pain News is published quarterly and is edited by Dr Arasu Rayen. Members of the Society will receive a free copy and are encouraged to contribute to the content.

    Media Partners


    Hospital & Healthcare Management

    Supporters
    https://www.hhmglobal.com/media-pack



    Gate2Biotech

    Supporters
    http://www.gate2biotech.com

    Gate2Biotech is a portal that unites biotechnological community in Central Europe. It covers all the news in the field of biotechnology. Thanks to the the portal the companies engaged in the field can easily search for research institutions and other partners to solve technical problems they are facing and here they can also present their services offer to potential partners from the Czech Republic and abroad. Gate2Biotech portal serves as a bridge connecting scientific and commercial sector. It incorporates offices and support organizations dedicated to promoting transfer of innovative technologies into a unified communication platform of Czech and international biotechnologies. As a mediator of information it draws attention to biotechnologies and support of their application and transfer into practice. It also functions as a tool for encouraging non-professionals (especially scientists and students) towards innovative business or applied research.


    International Pharmaceutical Industry

    Supporters
    http://www.ipimediaworld.com

    IPI gives you an insight into all areas of Biopharm, Medical, Pharmaceutical and Healthcare. IPI provides a proven supportive means of communication to the Pharmaceutical, Bio Pharmaceutical, Nutraceutical and Medical Devices industry, incorporating the latest in research and technology innovations, regulatory guidelines, marketing and communication strategies.


    Drug Discovery Today

    Supporters
    http://www.drugdiscoverytoday.com/

    Drug Discovery Today covers the whole of the preclinical drug discovery process. The reviews are cutting edge, written by experts in their respective fields and cover all aspects of drug discovery from genomic and proteomic approaches, computational drug design, medicinal chemistry and the translation of these sciences to therapies.


    Pharmavision

    Supporters
    http://www.pharmavision.co.uk

    PharmaVision offers a consultancy service providing independent pharmaceutical thematic research to the healthcare industry, the investment community and competitive intelligence specialists. We perform due diligence research and provide expert commentary in healthcare. Our reports combine scientific analysis in drug delivery, R&D technologies and pharmaceutical products including patient modelling, product/technology forecasts and market trends evaluation.


    Farmavita

    Supporters
    https://farmavitar.com

    FarmavitaR+ is the professional network of experts and service providers. Network is gathering local consultants from 90 countries in Europe, Asia, North America, Latin America, Australia and Africa. Management of international, multi-centre projects is our core competence. FarmavitaR+ is providing solutions related to pharmaceutical, medical device, food supplement and cosmetic products. Scope of services is related to solutions for product development, quality assurance, clinical trials, product registration, portfolio analysis, lifecycle management, vigilance/risk management, pricing/reimbursing, market access and promotional compliance. FarmavitaR+ is brand name of Farmavita Regulanet Ltd. Visit https://farmavitar.com for more information. Outsource anything you can think of!


    Pharmaceutical Technology

    Supporters
    http://www.pharmaceutical-technology.com

    Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.


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    Supporters
    http://www.biocompare.com

    Biocompare.com is the leading resource for up-to-date product information, product reviews, and new technologies for life scientists. Biocompare combines an in-depth knowledge of life science products and new technologies with the power of the Internet to offer scientists the most dynamic, relevant, and innovative media-based marketplace for life science information.


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    http://www.genengnews.com

    Genetic Engineering & Biotechnology News (GEN) is the most authoritative and widely read biotechnology news publication in the world.Published 21 times a year,GEN's unique news and technology focus include the entire bioproduct life cycle from early-stage R&D to applied research and bioprocess through to commercialization. GEN is the only publication that provides the full range of the biotechnology market coverage in areas such as omics, drugs and biomarker discovery, bioprocessing, clinical research, molecular diagnostics and biobusiness. For a free subscription go to: http://www.genengnews.com/subscriptions.aspx


    Drug Development Technology

    Supporters
    http://www.drugdevelopment-technology.com

    Drugdevelopment-technology.com covers every aspect of the drug development and research process, from conception to pre-FDA approval. Our global network of journalists updates the site with the latest and most significant industry developments. This coverage allows us to provide everyone - from senior management through to research and QA staff – with in-depth reviews of the latest projects, advance notice of new product releases and analysis of the latest procedural and legislative developments.


    Technology Networks

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    http://go.technologynetworks.com/subscribe-to-newsletters

    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com


    Select Science

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    SelectScience is an independent, online information resource for the worldwide scientific community, and the home of trusted information for laboratory scientists. Discover impartial, expert opinion and trusted reviews about latest laboratory equipment and techniques; plus videos, application notes and science news from around the world. Become a member for free today.


    Contract Biotechnology

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    http://www.contract-biotechnology.com

    Contract-Biotechnology.com is a web-based platform for laboratory outsourcing solutions. It is an online R&D matching tool that connects Scientifics and service and product providers worldwide. The platform Contract-Biotechnology.com would help you in the process of finding the right partner saving time and money, because with one single and secure application you would be able to receive multiple quotes quickly, keeping your contact information confidential. Contract-Biotechnology.com is the new Collaboration Network Model for Discovery Research and Development. Contract-Biotechnology.com team has extensive experience working for pharmaceuticals, biotechs, universities and academic research institutes and can help you addressing your key gaps.


    Mednous

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    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com

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