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Diabetes, Cardiovascular and Renal Complications
28 November - 29 November 2012
Diabetes, Cardiovascular and Renal Complications

Set to double from $32bn to $64bn over the next 15 years, the global diabetes market is set for stellar growth as changing demographics and new therapies begin entering the clinic.

Diabetes is now at epidemic levels and will account for eight percent of the world’s adult population by 2030. As the number of diabetics grows, so will the need for new treatments to mitigate the effects on the vasculature and renal system. In a vicious cycle, diabetics have four times the rate of heart disease as non-diabetics, while those with kidney problems are up to 100 times more susceptible to heart attacks and stroke than non-diabetics. With up to 50 million people currently affected by diabetic heart disease and 100 million forecast by 2025, more effective therapeutics are desperately needed. 

FEATURED SPEAKERS

James F. List

James F. List

Vice President and Full Development Lead, Dapagliflozin, Bristol-Myers Squibb
John Wilding

John Wilding

Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital
Martin Siman

Martin Siman

Director, Design and Interpretation Centre of Excellence , AstraZeneca
Philip Ambery

Philip Ambery

Director, Clinical Development, GlaxoSmithKline
Sandra Souza

Sandra Souza

Team Lead, Molecular Biomarkers, PPDM , Merck Sharp & Dohme

Arne Ring

Head of the Statistics and Modelling Group, Diabetes Trials Unit, University Of Oxford
Arne Ring

Frederick Tam

Reader in Renal Medicine, Imperial College Of Science Technology & Medicine
Frederick Tam

Haya Langerman

Medical Advisor, Merck Sharp & Dohme Ltd
Haya Langerman

James F. List

Vice President and Full Development Lead, Dapagliflozin, Bristol-Myers Squibb
James F. List

Jerry Buysse

Chief Scientific Officer and Senior Vice President, Research, Relypsa
Jerry  Buysse

John Warren

Director, Medicines Assessment Ltd
John Warren

John Wilding

Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital
John Wilding

Luigi Gnudi

Professor of Diabetes and Metabolic Medicine, Honorary Consultant in Diabetes and Endocrinology, Head, Unit for Metabolic Medicine, Cardiovascular Division, Kings College London
Luigi Gnudi

Martin Siman

Director, Design and Interpretation Centre of Excellence , AstraZeneca
Martin Siman

Patric Turowski

Senior Lecturer, Cell Biology, Institute of Ophthalmology, University College London
Patric Turowski

Peter Feldschreiber

Barrister, Four New Square
Peter Feldschreiber

Philip Ambery

Director, Clinical Development, GlaxoSmithKline
Philip Ambery

Rebecca Taub

Chief Executive Officer, Madrigal Pharmaceuticals
Rebecca Taub

Sandra Souza

Team Lead, Molecular Biomarkers, PPDM , Merck Sharp & Dohme
Sandra Souza

Sanjay Patel

Global Clinical Development Lead - Diabetes, Boehringer Ingelheim
Sanjay Patel

Vera Schrauwen-Hinderling

Assistant Professor, University of Maastricht Medical Centre
Vera Schrauwen-Hinderling

Conference agenda

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13:30

Registration & Coffee

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14:00

An introduction to cardiorenal disease in diabetes

Luigi Gnudi

Luigi Gnudi, Professor of Diabetes and Metabolic Medicine, Honorary Consultant in Diabetes and Endocrinology, Head, Unit for Metabolic Medicine, Cardiovascular Division, Kings College London

  • The relationship between cardiovascular disease and nephropathy in diabetes
  • Glomerular injury initiated by metabolic and haemodynamic insults
  • Pathways involved in the pathogenesis of diabetic glomerulopathy
  • Clinical insights from translational medicine
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    15:00

    Joint group discussion (disease treatments)

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    16:00

    Afternoon Tea

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    16:20

    Joint group discussion (answers from clinical trials – surrogate markers)

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    17:00

    End of workshop and private consultations with attendees

    Luigi Gnudi

    Luigi Gnudi, Professor of Diabetes and Metabolic Medicine, Honorary Consultant in Diabetes and Endocrinology, Head, Unit for Metabolic Medicine, Cardiovascular Division, Kings College London

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Martin Siman

    Martin Siman , Director, Design and Interpretation Centre of Excellence , AstraZeneca

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    9:10

    Cardiovascular outcome trials in diabetes- where are we heading?

    Arne Ring

    Arne Ring, Head of the Statistics and Modelling Group, Diabetes Trials Unit, University Of Oxford

  • The Rosiglitazone story
  • How diabetes guidelines change(d) trial designs for cardiovascular trials
  • Recent examples of trial designs
  • How to conduct these pragmatic trials in an efficient way
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    9:50

    Cardiovascular risk: shifting regulatory perspectives

    John Warren

    John Warren, Director, Medicines Assessment Ltd

  • FDA's response to Vioxx
  • FDA's response to Glitazones
  • FDA's response to obesity drugs
  • Litigation and risk >2
  • EU regulatory position
  • Implications of cardiovascular safety threshold for efficacy assessment
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    10:30

    Morning Coffee

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    11:00

    Introduction to DPP4 inhibitors

    Haya Langerman

    Haya Langerman, Medical Advisor, Merck Sharp & Dohme Ltd

  • Update on clinical data: Chronic renal insufficiency
  • Cardiovascular properties of incretins
  • Recent data
  • Research questions on incretins
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    11:40

    The legal liabilities risks of inadequately defined risk

    Peter Feldschreiber

    Peter Feldschreiber, Barrister, Four New Square

  • Risk/benefit assessments: clinical prognostic risk, socio-economic and environmental risks, consumer protection, intellectual property, commercial risks and risk of criminal sanctions
  • Risk/benefit profile: current international legislation and regulatory objectives for medicinal products
  • Examples of regulatory failure: Vioxx, Seroxat, the glitazones and TGN1412
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    12:20

    Networking Lunch

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    13:20

    Therapeutic targets to reduce cardiovascular disease in type 2 diabetes

    Philip Ambery

    Philip Ambery, Director, Clinical Development, GlaxoSmithKline

  • Links between diabetes and CVD
  • Novel diabetes drugs and CVD
  • Future direction
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    14:00

    The kidney as a target for diabetes treatment: from concept to clinical reality

    John Wilding

    John Wilding, Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital

  • Normal renal glucose transport
  • Does altered renal glucose transport contribute to hyperglycaemia in diabetes?
  • Blocking renal glucose transport – theoretical considerations
  • SGLT2 inhibitors as treatment for diabetes: benefits and risks
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    14:40

    Dapagliflozin in subjects with type 2 diabetes

    James F. List

    James F. List, Vice President and Full Development Lead, Dapagliflozin, Bristol-Myers Squibb

  • Inhibition of renal glucose re-uptake
  • Effects of urinary glucose excretion on glycaemic control and weight
  • Renal, cardiovascular, and other safety observations
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    15:20

    Afternoon Tea

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    15:40

    Panel discussion: Assessing endpoints in diabetic cardiovascular complications- where are we and what are the prospects for the future?

  • Glycemic efficacy and safety assessment across various sub-populations
  • Assessment of macrovascular safety and microvascular outcomes
  • What HTAs require from drug developers
  • What is the ideal degree of safety assurance?
  • What is the practical level of safety assurance pre- and post-marketing?
  • James F. List

    James F. List, Vice President and Full Development Lead, Dapagliflozin, Bristol-Myers Squibb

    John Warren

    John Warren, Director, Medicines Assessment Ltd

    Arne Ring

    Arne Ring, Head of the Statistics and Modelling Group, Diabetes Trials Unit, University Of Oxford

    John Wilding

    John Wilding, Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital

    Philip Ambery

    Philip Ambery, Director, Clinical Development, GlaxoSmithKline

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    16:20

    Efficacy and safety of Linagliptin in phase IIIa and IIIb programs and in various sub-populations

    Sanjay Patel

    Sanjay Patel, Global Clinical Development Lead - Diabetes, Boehringer Ingelheim

  • Glycemic efficacy and safety assessment across various sub-populations
  • Assessment of macrovascular safety
  • Assessment of microvascular outcomes
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    17:00

    Chairman’s Closing Remarks and Close of Day One

    Luigi Gnudi

    Luigi Gnudi, Professor of Diabetes and Metabolic Medicine, Honorary Consultant in Diabetes and Endocrinology, Head, Unit for Metabolic Medicine, Cardiovascular Division, Kings College London

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    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    John Wilding

    John Wilding, Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital

    clock

    9:10

    Inflammatory cytokines, profibrotic growth factor biomarkers and therapeutic targets in diabetic nephropathy & obesity-related glomerulopathy

    Frederick Tam

    Frederick Tam, Reader in Renal Medicine, Imperial College Of Science Technology & Medicine

  • Diabetic nephropathy is the most common cause of renal failure
  • Obesity is associated with glomerular disease, which may progress to renal failure
  • Urinary cytokines and pro-fibrotic growth factors are non-invasive biomarkers for progression of renal diseases
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    9:50

    Lipotoxicity in type 2 diabetes

    Vera Schrauwen-Hinderling

    Vera Schrauwen-Hinderling, Assistant Professor, University of Maastricht Medical Centre

  • Why does fat accumulate in cardiac muscle?
  • The association between cardiac steatosis and cardiomypoathy in type two diabetes
  • Mechanistic effects of lipoapoptosis
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    10:30

    Morning Coffee

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    11:00

    Diabetic retinopathy: focus on vascular permeability and oedema

    Patric Turowski

    Patric Turowski, Senior Lecturer, Cell Biology, Institute of Ophthalmology, University College London

  • Clinical manifestations of macular oedema
  • Properties and features of the blood-brain and retinal barriers
  • Mechanisms of VEGF induced vascular permeability
  • Potential role for leukostasis in diabetic retinopathy
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    11:40

    Control of hyperkalemia to extend the benefits of aldosterone blockade in diabetic nephropathy and heart failure

    Jerry  Buysse

    Jerry Buysse, Chief Scientific Officer and Senior Vice President, Research, Relypsa

  • RAAS inhibition represents the cornerstone of therapy that serves to preserve renal function and delay disease progression
  • Despite demonstrated cardio- and renoprotective outcomes in RAAS blockade studies, hyperkalemia associated with RAAS therapy often prevents optimum use of the drugs
  • The novel, high capacity potassium binding polymer, RLY5016, has been developed to prevent and treat hyperkalemia in heart failure and diabetic nephropathy patients, particularly in patients receiving long term RAAS therapy
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    12:20

    Networking Lunch

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    13:40

    Treatment of diabetic dyslipidemia

    Rebecca Taub

    Rebecca Taub, Chief Executive Officer, Madrigal Pharmaceuticals

  • Dyslipidemia as a leading factor in the formation of atherosclerosis
  • Diabetics in particular have additional risks and therapeutic needs for lipid modifiers
  • Impact of lowering of LDL cholesterol, triglycerides and Lp(a)
  • 3196: a liver-directed thyroid hormone receptor-beta agonist for the treatment of hypercholesterolemia
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    14:20

    An integrated “omics” approach to discover and validate FGF21 target engagement biomarkers

    Sandra Souza

    Sandra Souza, Team Lead, Molecular Biomarkers, PPDM , Merck Sharp & Dohme

  • Phosphoproteomic profiling of cultured adipocytes
  • Transcriptomic profiling of mouse adipose tissue; identification of RNA transcripts and secreted proteins
  • In vivo validation of proposed target engagement biomarkers
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    15:00

    Chairman’s Closing Remarks and Close of Day Two

    John Wilding

    John Wilding, Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology, University of Liverpool Hospital

    clock

    15:10

    Afternoon Tea


    Director
    Medicines Assessment Ltd
    Professor of Diabetes and Metabolic Medicine, Honorary Consultant in Diabetes and Endocrinology, Head, Unit for Metabolic Medicine, Cardiovascular Division
    Kings College London
    Senior Lecturer, Cell Biology
    Institute of Ophthalmology, University College London
    Barrister
    Four New Square
    Global Clinical Development Lead - Diabetes
    Boehringer Ingelheim
    Assistant Professor
    University of Maastricht Medical Centre
    Chief Scientific Officer and Senior Vice President, Research
    Relypsa
    Reader in Renal Medicine
    Imperial College Of Science Technology & Medicine
    Medical Advisor
    Merck Sharp & Dohme Ltd
    Vice President and Full Development Lead, Dapagliflozin
    Bristol-Myers Squibb
    Director, Design and Interpretation Centre of Excellence
    AstraZeneca
    Head of the Statistics and Modelling Group, Diabetes Trials Unit
    University Of Oxford
    Professor of Medicine & Honorary Consultant Physician, Head of Department of Obesity and Endocrinology
    University of Liverpool Hospital
    Director, Clinical Development
    GlaxoSmithKline
    Chief Executive Officer
    Madrigal Pharmaceuticals
    Team Lead, Molecular Biomarkers, PPDM
    Merck Sharp & Dohme

    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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