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The Use of Animal Models in Pre-Clinical Drug Development
22 March 2017
The Use of Animal Models in Pre-Clinical Drug Development

 The workshop will provide an overview of the use of animal
models in preclinical drug development. We will focus on
the transition from in vitro activity to in vivo efficacy, the
choice of the right animal model for proof of concept
studies, provide examples of relevant animal models with
supportive data and interpretation of results as it relates to
the clinical condition.

Workshop LEADER

keynote-img

Mark Pulse

Assistant Director , University of North Texas Health Science Center

Mark Pulse has primarily been focused on bacterial
pathogenesis and pre-clinical drug evaluation within in
vivo models. For the last 10years he has been directly
involved in the development of several in vivo models that
have included GI- and respiratoryassociated infectious
diseases, device-associated (biofi lm) infections, and
pharmacokinetic studies within multiple animal species. He
also has experience with survival surgery in multiple animal
species, including USDA species.

University of North Texas Health Science Center

 

The Pre-Clinical Services group at the University of North Texas Health Science Center conducts studies utilizing established models of both acute and chronic bacterial infections in several different animal species. In addition, pharmacokinetic studies with accompanied bioanalytical LCMS / HPLC analysis can be performed in-house for submitted compounds.
Infection models or protocols other than those described herein can also be established or adapted as required to meet the more specific needs of interested Sponsors.
UNTHSC Pre-clinical Services together has over 33 years of pharmaceutical and specialized biotech experience in the performance of therapeutic efficacy models and drug discovery / development. The group uses this experience to guide the drug discovery process, through protocol design, implementation and analysis for compound lead selection. Studies are conducted in state-of-the-art facilities with excellent support staff and services.
 

Workshop agenda

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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9:10

Pre-Clinical Drug Development

• Overview of preclinical testing
• Discovery to lead selection
• The development model: then and now
• Antibacterial research efforts
 

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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9:50

Experimental Design and Methodology

• Experimental design profoundly influences
the outcome of a research study
• Clearly define the question or problem
being studied
• Realistic objectives (achievable)
• Choose the best research model

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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10:30

Morning Coffee

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11:00

Animal Models – Examples

• Acute infection models – Bacteremia, Sepsis
• Chronic infection models – Pneumonia, skin,
abscesses
• GI related – C. difficile, H. pylori

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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12:20

Animals in Research

• Institutional Animal Care and Use Committee
(IACUC)
• Justify why animals are necessary, minimize pain
and distress, husbandry and care
• Use of appropriate euthanasia methods
• The 3 R’s

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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12:30

Close of Workshop

William Weiss, Director of Pre-Clinical Services, University of North Texas Health Science Center

Mark Pulse, Assistant Director , University of North Texas Health Science Center

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