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Adaptive Designs for Multi-Armed Trials
2 February 2010
Adaptive Designs for Multi-Armed Trials

About the workshop

The workshop describes the statistical principles for planning and conducting a multi-armed adaptive trial.  This includes an introduction into adaptive designs - what is meant by adaptive?  The focus of this workshop is on confirmatory adaptive designs mainly performed in phase II/III designs where control of Type I error rate is mandatory.  The ways of reaching a test decision, selecting treatment arms, calculating confidence intervals and p-values are described.  Finally, software for performing such analyses is presented and illustrated by examples.

About the host

Gernot Wassmer 

Gernot Wassmer, Professor, Institute for Medical Statistics, Informatics and Epidemiology (IMSIE), University of Cologne

Gernot Wassmer PhD is an Associate Professor for Biostatistics at the Institute of Medical Statistics at the University of Cologne in Germany.  He received his PhD in 1993 at the University of Munich, Germany.  From 1993-2000, he was a Research Fellow at the Institute of Statistics at the University of Munich, also at the Institute for Epidemiology, GSF Neuherberg, and at the Institute of Medical Statistics, University of Cologne.  He also works as a statistical consultant for the pharmaceutical industry.  His major research interest is in the field of statistical procedures for group sequential and adaptive plans in clinical trials.

University of Cologne 

 About the organisation

The University of Cologne is a research university at the highest level with more than 250 co-operating instututes and departments.  The Institute for Medical Statistics, Informatics and Epidemiology offers research, teaching services and consultancy with special emphasis on biometrical reserach and its applications in clinical trials.

Workshop agenda

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8:30

Registration & Coffee

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9:00

Welcome & Introductions

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9:10

Background to Adaptive Designs

  • The Combination Testing principle
  • Adaptive seamless designs
  • The Closed Testing principle
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    9:50

    Statistical Issues

  • Testing procedures for multi-armed designs
  • Designing parameters
  • Comparison of the procedures
  • Overall p-values and confidence intervals
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    10:30

    Morning Tea

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    10:50

    Practical Performance

  • Software for planning and analysing multi-armed trials
  • Practical examples
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    11:30

    Discussion session

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    12:00

    Close of Workshop

    Crowne Plaza Hotel - St James

    Buckingham Gate 45/51
    London SW1E 6AF
    United Kingdom

    Crowne Plaza Hotel - St James

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