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Precision Nano-therapeutics: Minding the gap in delivery from preclinical studies to clinical success
21 February 2017
Precision Nano-therapeutics: Minding the gap in delivery from preclinical studies to clinical success

The need for functional delivery of RNAi effectors to target
cells is a primary problem that is holding back the field of
RNAi therapeutics. Nanoparticles, molecular conjugates,
and other delivery technologies have their place but are
they really working well enough? If not why not? And if they
do appear to be working, what will it actually take to realise
clinical success? This workshop is designed to help attendees
appreciate the magnitude of the gap that must be bridged
between academic-preclinical studies and the needs of the
pharma industrial for success in RNAi therapeutics

Workshop agenda

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8:30

Registration & Coffee

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9:00

Session 1: Where are we really with functional RNAi effector delivery?

Andrew Miller, Professor of Organic Chemistry & Chemical Biology, Kings College London

  • Do RNAi effectors need a delivery system in vivo?
  • What delivery systems are most biocompatible?
  • How effective are delivery systems today?
  • Where should the state of the art be developed?
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    9:50

    Session 2: Bridging the gap from lab preparation to kg manufacture

    Andrew Miller, Professor of Organic Chemistry & Chemical Biology, Kings College London

  • The importance of cGMP manufacture
  • What are key problems in scale-up manufacture?
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    10:30

    Morning Coffee

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    11:00

    Session 3: Integrated development plans-nonclinical studies to clinic

    Andrew Miller, Professor of Organic Chemistry & Chemical Biology, Kings College London

  • Developing a target product profile
  • Mapping out an integrated development plan
  • Addressing regulatory issues at all stages of development
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    11:45

    Session 4: Improving on the status quo

    Andrew Miller, Professor of Organic Chemistry & Chemical Biology, Kings College London

  • How close are we to routine RNAi therapeutics?
  • What are critical problems to address going forward?
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    12:20

    Closing Remarks

    Andrew Miller, Professor of Organic Chemistry & Chemical Biology, Kings College London

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    12:30

    End of workshop

    Copthorne Tara Hotel

    Scarsdale Place
    Kensington
    London W8 5SR
    United Kingdom

    Copthorne Tara Hotel

    The Copthorne Tara Hotel London Kensington is an elegant contemporary four-star hotel in prestigious Kensington, located just a two minutes walk from High Street Kensington underground station, making exploring easy. The hotel offers well-appointed and comfortable guest rooms combining Standard, Superior and Club accommodation. Club rooms offer iconic views over the city and include Club Lounge access for complimentary breakfast and refreshments. Guests can sample the authentic Singaporean, Malaysian and Chinese cuisine at Bugis Street, traditional pub fare at the Brasserie Restaurant & Bar or relax with a delicious drink at West8 Cocktail Lounge & Bar.

    The Copthorne Tara Hotel boasts 745 square meters of flexible meeting space, consisting of the Shannon Suite and the Liffey Suite, ideal for hosting conferences, weddings and social events. Facilities include access to the business centre 24 hours a day, fully equipped fitness room, gift shop, theatre desk and Bureau de Change. With ample onsite parking outside the London congestion charge zone and excellent transport links via Heathrow Airport, the hotel is the perfect location for business or leisure stays. The hotel is within close proximity to the shops of High Street Kensington, Knightsbridge and Westfield London, Olympia Conference Centre, Royal Albert Hall, Kensington Palace and Hyde Park.

     

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

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    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

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    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

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    GLOBAL CPD

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