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COPD: Novel Therapeutics and Management Strategies
19 October - 20 October 2011
COPD: Novel Therapeutics and Management Strategies

 

 
 

SAE Media Group proudly present their 3rd annual COPD: Novel Therapeutics and Management Strategies conference to be held in Central London on Wednesday 19th and Thursday 20th of October 2011. Bringing together high level industry representatives as well as highly respected academic and medical figures, this is your opportunity to enjoy presentations on the latest hot topics surrounding COPD and to network with key industry professionals.

This conference continues to promote increased awareness of COPD and explores ways to improve quality of life for patients, prevention of exacerbations and analyses the new treatment techniques developed over the previous twelve months.

The conference agenda covers every phase of COPD study. We begin with a clinical perspective taking into account new targets for COPD and lessons that can be learned in future development and desgin. The most controversial of these novel therapeutics, roflumilast, is explored from a pharmacological and clinical perspective. This is followed with looks at combination and inhaled therapeutics. 

The agenda focuses on discovery and devlopment from various interesting viewpoints, with pre and post clinical modelling and strategy addressed as well as Phase I & II studies.

 


 

Current Registered Attendess from the following companies include: Almirall, Argenta Discovery Ltd, Bayer Schering Pharma, Biomedical Systems Europe, Boehringer Ingelheim, GlaxoSAE Media Groupthkline Biologicals, Grunenthal Gmb H, GSK, Hovione SA, Imperial College School of Medicine (N.H.L.I.), Johnson & Johnson, Kyorin Pharmaceutical Co Ltd, National Heart & Lung Institute, Nycomed GmbH, ProtAffin Biotechnologie AG, Revotar Biopharmaceuticals, Sandoz International Gmbh, Teva UK Limited, Vectura & Vitalograph Ltd

 

  • Professor Bill MacNee, Professor of Medicine, University of Edinburgh  
  • Professor Sebastian Johnston, Professor of Adult Respiratory Medicine, Imperial College School of Medicine
  • Professor Neil Barnes, Consultant Respiratory Physician, Barts & The London NHS Trust
  • Andreas Pahl, Head of Pharmacology, Nycomed 
     

Conference agenda

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13:30

Registration & Coffee

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14:00

Introduction

René van der Merwe

René van der Merwe, Director - Clinical Development, Respiratory and Inflammation, MedImmune

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14:10

Proof of Concept Trials in COPD - an Overview

René van der Merwe

René van der Merwe, Director - Clinical Development, Respiratory and Inflammation, MedImmune

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15:00

Afternoon Tea

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15:30

Challenge models in COPD - an Overview

René van der Merwe

René van der Merwe, Director - Clinical Development, Respiratory and Inflammation, MedImmune

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16:15

Case Studies

René van der Merwe

René van der Merwe, Director - Clinical Development, Respiratory and Inflammation, MedImmune

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17:00

Feedback & closing remarks

René van der Merwe

René van der Merwe, Director - Clinical Development, Respiratory and Inflammation, MedImmune

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, Imperial College School of Medicine (N.H.L.I.)

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9:10

Aetiology & pathogenesis of exacerbations of COPD

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, Imperial College School of Medicine (N.H.L.I.)

• Role of bacteria and viruses in COPD exacerbations
• Human and mouse models of COPD exacerbations
• Mechanisms of COPD exacerbations
• Identification of novel approaches to therapy

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9:50

Reducing the burden of COPD by targeting skeletal muscle mass and function

Michael Steiner

Michael Steiner, Consultant Respiratory Physician, University Hospital Leicester

• Evidence to support the importance of skeletal muscle dysfunction in COPD
• The benefits of physical training
• The potential for the skeletal muscles to be a target for drug development in COPD.

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10:30

Morning Coffee

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11:00

COPD, a developing disease: clinical perspective and lessons from Asthma

Ewan Walters

Ewan Walters, Medical Director, Teva UK Ltd

• Pathogenesis
• COPD as a developing disease
• Development of COPD specific therapies
• Inherent difficulties with the disease
• A bright future?

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11:40

Panel Discussion: Novel Therapeutics and unmet needs in COPD

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, Imperial College School of Medicine (N.H.L.I.)

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12:40

Networking Lunch

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13:50

Clinical testing and uses of ‘roflumilast’

Neil Barnes

Neil Barnes, Consultant Respiratory Physician, Barts & The London NHS Trust

• Deciding who should use roflumilast
• Correct dosages
• How long should it be used for
• What evidence of improvements to look for in patients using it
• When to stop administering roflumilast
 

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14:30

Combination therapy for COPD

Mary Fitzgerald

Mary Fitzgerald, Executive VP, Respiratory, Pulmagen Therapeutics

• New ICS/LABA combinations: What and why
• Switching on Inhaled Corticosteroids: Novel anti-inflammatory combinations
• Combination bronchodilators: Optimising symptomatic benefit

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15:10

Afternoon Tea

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15:40

Inhaled models of Inflammation in Phase I/II clinical trials

Graham Clarke

Graham Clarke, Head of Respiratory Phase I, Quintlies Ltd.

• Integrated Phase I study designs
• Addressing mechanism of action
• Allergen, LPS and Ozone challenges
• Surrogate biomarkers – Nasal challenge

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16:20

Anti-inflammatory therapies

Daniel Bock

Daniel Bock, Director Preclinical and Clinical R&D, Revotar Biopharmaceuticals

• Targeting inflammation in COPD: options and limitations
• Approved and emerging anti-inflammatory drugs for the treatment of COPD
• Translating anti-inflammatory potency into clinical benefit
 

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17:00

Chairman’s Closing Remarks and Close of Day One

Sebastian Johnston

Sebastian Johnston, Professor of Respiratory Medicine, Imperial College School of Medicine (N.H.L.I.)

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8:30

Registration & Coffee

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9:00

Chairman's Opening Remarks

Maria Belvisi

Maria Belvisi, Head of Respiratory Pharmocology Group, Imperial College

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9:10

Diagnosing and Phenotyping COPD Patients

Bill MacNee

Bill MacNee, Professor of Medicine, University Of Edinburgh Medical School

• COPD is a heterogeneous condition and although definition is based around the measurement of airflow limitation, the FEV1 does not describe the heterogeneity of the condition
• A number of proposed phenotypes of COPD have been suggested which may relevance for outcomes in COPD and targeted treatment
• COPD phenotypes and their clinical relevance will be described
• Future options for treatment targeted towards COPD phenotypes will be discussed

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9:50

Targeting the immunological basis of COPD

Matthew Catley

Matthew Catley, Head of Disease Area Pharmacology, UCB

• The immunology of COPD
• Autoimmunity and COPD
• Targeting the immunopathology of COPD

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10:30

Morning Coffee

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11:00

Rodent models of COPD exacerbations

Liz Hardaker

Liz Hardaker, Investigator II, Novartis

• What are exacerbations and why target them?
• What aspects of exacerbations can be modelled in rodent models?
• How can we translate the findings back to man?

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11:40

Pre-clinical models of COPD

Maria Belvisi

Maria Belvisi, Head of Respiratory Pharmocology Group, Imperial College

• Human and rodent tissue and cell based assays
• Pharmacodynamic models
• In vivo models of steroid resistant inflammation
• Functional endpoints

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12:20

Networking Lunch

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13:40

The Management of COPD exacerbations

Wisia Wedzicha

Wisia Wedzicha, Professor of Respiratory Medicine, University College London

  • Issues regarding acute exacerbations
  • Pharmacological & non-pharmacological management
  • Outcomes of exacerbations
  • Integration of services
  • Organisation of care

     

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    14:20

    Modelling clinical outcomes of COPD

    • Developing an ensemble outcome(clinical endpoints) model to enable therapeutic development in COPD
    • Statistical challenges
    • Progress so far

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    15:00

    Panel Discussion: COPD clinical trials from start to finish

    Maria Belvisi

    Maria Belvisi, Head of Respiratory Pharmocology Group, Imperial College

    Graham Clarke

    Graham Clarke, Head of Respiratory Phase I, Quintlies Ltd.

    Wisia Wedzicha

    Wisia Wedzicha, Professor of Respiratory Medicine, University College London

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    16:00

    Afternoon Tea and Close of Day Two

    Workshops

    Rapid Proof of Concept in COPD trials

    Rapid Proof of Concept in COPD trials

    The Grange Holborn Hotel
    18 October 2011
    London, United Kingdom

    The Grange Holborn Hotel

    50-60 Southampton Row
    London WC1B 4AR
    United Kingdom

    The Grange Holborn Hotel

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

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    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

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    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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