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SAE Media Group is proud to announce the return of their 3rd annual Peptides event to London in 2016!



In recent years, therapeutic peptides have been developed for the treatment of several diseases such as cancer, metabolic disorders, nervous system disorders and gastrointestinal disorders, among others. Further research has been done to develop a rich pipeline of novel peptides as a result of their efficacy treating a huge array of conditions, and the global peptide therapeutics market is expected to reach a value of US$23.7B by 2020*

SAE Media Group’s 3rd annual Peptides event provides the perfect platform to discuss the latest innovations and development in the peptides industry and explore a number of pressing issues such as the use of Cell Penetrating Peptides (CPP), the challenges involved with oral peptides and many more.

*http://www.prnewswire.com/news-releases/peptide-therapeutics-market-will-rise-at-a-moderate-28-cagr-to-touch-us237-bn-by-2020-transparency-market-research-566039311.html



 


 

FEATURED SPEAKERS

Dan Teufel

Dan Teufel

Head of Chemistry, Bicycle Therapeutics Limited
Daniel Samson

Daniel Samson

Director API Manufacturing, Bachem
Evelyne Fontaine

Evelyne Fontaine

Scientist, Sanofi-Aventis
Leila Narimen Beniddir

Leila Narimen Beniddir

Study Manager/Scientist- Novel Drug Delivery Technologies, Ipsen
Lutz Jermutus

Lutz Jermutus

Senior Director, R&D, MedImmune

Ashok Bhandari

VP, Chemistry, Protagonist Therapeutics
Ashok Bhandari

Bill Eldridge

CSO, Cyclogenix
Bill Eldridge

Dan Teufel

Head of Chemistry, Bicycle Therapeutics Limited
Dan Teufel

Daniel Samson

Director API Manufacturing, Bachem
Daniel Samson

After obtaining his PhD in organic chemistry Daniel joined Bachem's peptide manufacturing headquarters in Switzerland in 2007. As a team leader he has been responsible for the synthesis of peptides and small proteins. From 2009 to 2011 he held a lab head position focusing on process optimization, technology transfer and scale-up of synthetic peptide manufacturing procedures. In 2010 Daniel joined Bachem in the United Kingdom temporarily focusing on non-GMP custom syntheses of peptides. From the beginning of 2012 he has been leading Bachem’s cGMP API manufacturing groups back in Switzerland applying large scale SPPS and preparative HPLC. Science 2015 he is a Senior Director and has responsibility for all peptide API manufacturing aspects within Bachem AG.

Elisabetta Bianchi

Head of Peptide Chemistry , IRBM Science Park
Elisabetta Bianchi

Evelyne Fontaine

Scientist, Sanofi-Aventis
Evelyne Fontaine

Gary Bembridge

Director of Scientific Affairs Immunology, Abzena
Gary  Bembridge

Joanna Hay

Science Manager, Albumedix
Joanna Hay

Jonathan Ryves

Director, Cupid Peptides
Jonathan  Ryves

Leila Narimen Beniddir

Study Manager/Scientist- Novel Drug Delivery Technologies, Ipsen
Leila Narimen Beniddir

Lutz Jermutus

Senior Director, R&D, MedImmune
Lutz Jermutus

Mathias Schaffrath

Group Head Chromatography, Sanofi
Mathias  Schaffrath

Oliver Demmer

Innovation Consultant, Innovation Centre Denmark, Ministry Of Foreign Affairs
Oliver Demmer

Renata Zbozien

Senior Scientist, Haemostatix Ltd
Renata Zbozien

Roger New

Director, R&D, Proxima Concepts Ltd
Roger New

Vincent Bille

Founder & Owner, Marble Pharma Consult, sprl
Vincent Bille

sponsors

Conference agenda

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8:30

Registration & Coffee

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9:00

Discovery methodologies

  • Why cyclic peptides will continue to show increased potential
  • Daniel Teufel

    Daniel Teufel, Head of Chemistry, Bicycle Therapeutics

    Roger New

    Roger New, Director, R&D, Proxima Concepts Ltd

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    10:00

    The development process

    • An overview of working with cyclic peptides
    • Methods for discovery of active compounds

    Daniel Teufel

    Daniel Teufel, Head of Chemistry, Bicycle Therapeutics

    Roger New

    Roger New, Director, R&D, Proxima Concepts Ltd

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    11:00

    Morning Coffee

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    11:30

    Applications in medicine

    • Current and future applications in treatment of models for disease

    Daniel Teufel

    Daniel Teufel, Head of Chemistry, Bicycle Therapeutics

    Roger New

    Roger New, Director, R&D, Proxima Concepts Ltd

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    12:30

    End of Workshop

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    13:30

    Registration and Coffee

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    14:00

    An introduction to CPPs

    Jonathan  Ryves

    Jonathan Ryves, Director, Cupid Peptides

    • What are CPPs? Discovery and
    development
    • A look at the different types of CPPs
    and their strengths and weaknesses
    • Using CPPs in Biomedical research

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    14:45

    An introduction to Cupid

    Jonathan  Ryves

    Jonathan Ryves, Director, Cupid Peptides

    • Demonstrating its capabilities using
    Cupid-GFP Protein

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    15:30

    Afternoon Tea

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    16:00

    The Future of CPPs - Therapeutic applications

    Jonathan  Ryves

    Jonathan Ryves, Director, Cupid Peptides

    • Cupid Stem Cell Project

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    16:45

    How can CPPs work for you?

    Jonathan  Ryves

    Jonathan Ryves, Director, Cupid Peptides

    • Real problems and solutions

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    17:30

    End of Workshop

    clock

    8:30

    Registration & Coffee

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    9:00

    Chairman's Opening Remarks

    Lutz Jermutus

    Lutz Jermutus, Senior Director, R&D, MedImmune

    clock

    9:10

    MEDI0382, a novel GLP1/glucagon co-agonist, as a promising therapeutic lead for the treatment of Type 2 diabetes and obesity

    Lutz Jermutus

    Lutz Jermutus, Senior Director, R&D, MedImmune

    • Pre-clinical summary
    • Clinical summary
    • Mechanism of action studies
     

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    9:50

    Purification of synthetic peptides by reversed phase chromatography

    Mathias  Schaffrath

    Mathias Schaffrath, Group Head Chromatography, Sanofi

    • High throughput purifi cation by automation
    • Mass triggered fractioning
    • High quality and good recovery of the fi nal product

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    10:30

    Morning Coffee

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    10:50

    Peptide materials for the targeted and responsive delivery of therapeutics

    • Background to self-assembling peptides
    • Design of sprayable and injectable delivery devices
    • How to control the temporal release of therapeutics
    • Exemplars for the delivery of small molecules, protein therapeutics and mRNA

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    11:30

    Assessing immunogenicity in peptide development

    Gary  Bembridge

    Gary Bembridge, Director of Scientific Affairs Immunology, Abzena

    • T-cell help as a risk factor in the development of
    anti-drug antibodies
    • Immunogenicity of peptides data updates
    • Deimmunisation of naturally immunogenic non-human protein therapeutics

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    12:10

    Networking Lunch

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    13:10

    Live learning lab: Strategy for successful GMP peptide development, scale-up and manufacturing

    Vincent Bille

    Vincent Bille, Founder & Owner, Marble Pharma Consult, sprl

    This interactive session will provide live insights related
    to process and analytical development, management
    of external supply operations. As well as demonstrate a life
    cycle approach to manufacturing of peptide APIs including
    process and regulatory dimensions.


    • Challenges and decision points from early process
    development
    • Scaling-up: strategy and cost optimisation
    • Validation and regulatory requirements
    • Contract manufacturing and outsourcing management

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    14:10

    Oral peptide delivery technology landscape

    Leila Narimen Beniddir

    Leila Narimen Beniddir, Study Manager/Scientist- Novel Drug Delivery Technologies, Ipsen

    • Current status
    • Particular considerations or oral peptide delivery
    • Approaches and strategies for oral peptide delivery

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    14:50

    Discovery of novel and potent orally stable peptide antagonists of the human IL-23 receptor and their pre-clinical POC in rat colitis models

    Ashok Bhandari

    Ashok Bhandari, VP, Chemistry, Protagonist Therapeutics

    • Discovery of novel peptides antagonist for human IL-23
    receptor that are
    • Orally stable, GI restricted
    • Selective
    • Effi cacious in rat TNBS colitis model

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    15:30

    Afternoon Tea

    clock

    15:50

    Using Cupid, a novel cell penetrating peptide, to carry GFP into cells

    Jonathan  Ryves

    Jonathan Ryves, Director, Cupid Peptides

    • Advances in Cupid CPP technology
    • Applications in stem cell research
    • Looking to the future

    clock

    16:30

    Design of the theranostic CXCR4 ligand Pentixafor and its application in man

    Oliver Demmer

    Oliver Demmer, Innovation Consultant, Innovation Centre Denmark, Ministry Of Foreign Affairs

    • Design of Pentixafor: N-methylated, cyclic peptides,
    dimers and peptoids
    • Optimisation of N-methylation/alkylation procedures
    and other peptide modifi cations
    • Effi cient on-resin strategies for the synthesis of branched
    and modifi ed peptides
    • PET imaging in man for cancer diagnosis using Pentixafor

    clock

    17:10

    Chairman’s Closing Remarks and Close of Day One

    Lutz Jermutus

    Lutz Jermutus, Senior Director, R&D, MedImmune

    clock

    8:30

    Registration & Coffee

    clock

    9:00

    Chairman's Opening Remarks

    Dan Teufel

    Dan Teufel, Head of Chemistry, Bicycle Therapeutics Limited

    clock

    9:10

    New synthetic anti tuberculosis cyclohexylgriselimycin, more than 50 years after the isolation of the natural griselimycin

    • Case study in peptide chemistry
    • Modern day optimisation of the natural compound
    Griselimycin (GM)
    • Novel mode of action and anti-TB properties

    Evelyne Fontaine

    Evelyne Fontaine, Scientist, Sanofi-Aventis

    clock

    9:50

    CMC case study: Process development, commercial manufacturing and quality control for generic peptide APIs

    Daniel Samson, Director API Manufacturing, Bachem

    • Chemical process development, scale-up and large
    scale manufacturing of the two generic peptide APIs
    Atosiban and Lanreotide
    • Analytical control strategy (starting material quality, inprocess
    controls, API specifications)
    • Comparison of process parameters and drug
    substance quality attributes from process performance
    qualification and commercial manufacturing

    clock

    10:30

    Morning Coffee

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    10:50

    Development of cytotoxic bicyclic peptide drug conjugates and applications in molecular targeted cancer therapy

    • Peptide drug development
    • Toxin Conjugate development
    • Radio-nuclide conjugates, biodistribution
    • Formulation (possibly), physchem etc
    • In vitro/vivo results

    Dan Teufel

    Dan Teufel, Head of Chemistry, Bicycle Therapeutics Limited

    clock

    11:30

    Developing a peptide coagulant and formulation to treat traumatic bleeding

    Renata Zbozien

    Renata Zbozien, Senior Scientist, Haemostatix Ltd

    • Unmet needs in the control of traumatic bleeding
    • Design of peptide coagulant and formulation
    • Progress to date

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    12:10

    Networking Lunch

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    13:10

    Enhanced drug delivery with Veltis® engineered albumins

    Joanna Hay

    Joanna Hay, Science Manager, Albumedix

    • Short circulatory half-life represents a major obstacle for
    many peptide-based therapeutics.
    • This can be signifi cantly improved by conjugation or
    fusion to albumin, due to increased size and recycling
    via the neonatal Fc receptor (FcRn).
    • The increased FcRn affi nity of the Veltis® engineered
    albumins translates to more than doubling of the already
    long half-life of native sequence albumin.
    • We will describe rationally engineered albumins and

    clock

    13:50

    Using Cyclotides for oral delivery of biotherapeutics.

    Bill Eldridge

    Bill Eldridge, CSO, Cyclogenix

    • Using Cyclotides for oral delivery of biotherapeutics.
    • Bispecific Cyclotides as a new class of Immuno-oncology agents.
     

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    14:30

    Afternoon Tea

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    14:50

    Strategies for peptide-based vaccines development for antiviral diseases

    Elisabetta Bianchi

    Elisabetta Bianchi, Head of Peptide Chemistry , IRBM Science Park

    • Identification of potentially protective epitopes
    • Design and conjugation of conformationally constrained epitopes
    • Strategies to enhance immunogenicity

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    15:30

    Vaccination via the oral route

    Roger New

    Roger New, Director, R&D, Proxima Concepts Ltd

    • Strategies for delivery to Peyer’s Patches
    • Deployment of sub-unit vaccines
    • Success in challenge models

    clock

    16:10

    Chairman’s Closing Remarks and Close of Day Two

    Dan Teufel

    Dan Teufel, Head of Chemistry, Bicycle Therapeutics Limited


    VP, Chemistry
    Protagonist Therapeutics
    CSO
    Cyclogenix
    Head of Chemistry
    Bicycle Therapeutics Limited
    Director API Manufacturing
    Bachem
    Head of Peptide Chemistry
    IRBM Science Park
    Scientist
    Sanofi-Aventis
    Director of Scientific Affairs Immunology
    Abzena
    Science Manager
    Albumedix
    Director
    Cupid Peptides
    Study Manager/Scientist- Novel Drug Delivery Technologies
    Ipsen
    Senior Director, R&D
    MedImmune
    Group Head Chromatography
    Sanofi
    Innovation Consultant
    Innovation Centre Denmark, Ministry Of Foreign Affairs
    Senior Scientist
    Haemostatix Ltd
    Director, R&D
    Proxima Concepts Ltd
    Founder & Owner
    Marble Pharma Consult, sprl

    Sponsors and Exhibitors

    Official Media Partner

    Official Publication

    Supporters

    Workshops

    Cupid Cell Penetrating Peptides – A Powerful New Tool

    Cupid Cell Penetrating Peptides – A Powerful New Tool

    Holiday Inn Kensington Forum
    5 July 2016
    London, United Kingdom

    Preliminary list of attendees - 2016

    Download

    Interview with Renata Zbozien, VP Research, Haemostatix

    Download

    Sponsors and Exhibitors


    Abzena

    Sponsors and Exhibitors
    http://www.abzena.com

    Abzena offers a suite of complementary services and technologies. Its range of technologies include immunogenicity assessment, antibody drug conjugation, protein engineering, PEGylation, cell line development , GMP manufacturing and a range of bespoke assays to enables the development of better biopharmaceuticals which will have a greater chance of reaching the market.


    Bachem

    Sponsors and Exhibitors
    http://www.bachem.com/

    Bachem provides comprehensive services to the pharma and biotech industries. It specializes in the development of innovative, efficient manufacturing processes and the reliable production of peptide-based APIs. The group has a global reach with more experience and know-how than any other company in the industry. Bachem. Pioneering Partner for Peptides

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    MedNous is a print publication and website about medical innovation in Europe. It carries exclusive interviews with companies that are at the forefront of medical technology, as well as contributor articles from prominent practitioners. Our mission is to identify significant advances in medicine and to explain how this innovation is being commercialised. In doing so, we talk to venture capitalists about what products and platforms they are supporting. We report on how regulators cope with the accelerating pace of innovation. And we regularly cover the latest developments in the discovery and development of new medical concepts in the area of antibodies, vaccines, small molecules, regenerative medicine and nanomedicines. MedNous combines the English word for medicine with the Greek word for intellect. And those with nous are readers of our publication. Visit our website: www.mednous.com


    Drug Target Review

    Supporters
    http://www.drugtargetreview.com

    Drug Target Review’s quarterly magazine, website and annual events program provides high quality content with peer-written articles that are submitted exclusively by the world’s most respected scientists in their field. This attracts a committed base of readers, users and delegates made up of senior decision-makers from the life science and drug discovery industries at the top pharmaceutical companies, as well as academics and scientists from the top research institutes across the globe.


    Drug Discovery World

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    http://www.ddw-online.com

    For over a decade DDW has continued to be the ‘must read’ journal within the DD&D Arena. DDW is recognised for voicing the opinions of some of the Industry’s leading luminaries and has become a recognised platform for Industry Gurus to debate some of the more challenging technological and business issues facing the the life science industry. DDW adheres to the maxim..... ‘Turning Science into Business’ DDW examines the advances in new technologies and the associated implications within the context of developing new and efficacious therapeutics. DDW is distinguishable in that it reaches out to a global audience at both bench and boardroom level, allowing both camps to profit from the uncomplicated style of editorial but at the same time challenges our readers to look at new ways to overcome discovery bottlenecks, embrace nascent technologies and build next generation technology platforms.


    Technology Networks

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    http://go.technologynetworks.com/subscribe-to-newsletters

    Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com

    Holiday Inn Kensington Forum

    97 Cromwell Road
    London SW7 4DN
    United Kingdom

    Holiday Inn Kensington Forum

    Holiday Inn Kensington Forum is perfectly situated in one of London’s most luxurious and beautiful areas within South Kensington. 

    The hotel is just 2 minutes walk from Gloucester Road tube station for convenient travel to Hyde Park, London Eye, Tower Bridge plus more of London’s top attractions. There are also easy and direct links to some major transport hubs including Victoria, Kings Cross St Pancras, Paddington and Heathrow. 

    This distinctive hotel in south London has so much to offer to make all guests really feel at home. The latest Holiday Inn relaunch is not just about the new look and feel for the hotel but to offer guests more benefits during their stay including a pillow menu for extra comfort during their sleep and a curved shower rail for more spacious feel. 

    In addition to our 906 rooms, all business guests can take advantage of our meeting and conference facilities including High Speed Internet Access and unlimited Starbucks coffee at The Academy. Our hotel’s professional event planners are on board to help take the hard work and stress away from planning your next event. 

    So whether you in London on business or pleasure, make the Holiday Inn London Kensington Forum your first choice of hotel and book your accommodation for our lowest internet rate guarantee. 

    HOTEL BOOKING FORM

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    WHAT IS CPD?

    CPD stands for Continuing Professional Development’. It is essentially a philosophy, which maintains that in order to be effective, learning should be organised and structured. The most common definition is:

    ‘A commitment to structured skills and knowledge enhancement for Personal or Professional competence’

    CPD is a common requirement of individual membership with professional bodies and Institutes. Increasingly, employers also expect their staff to undertake regular CPD activities.

    Undertaken over a period of time, CPD ensures that educational qualifications do not become obsolete, and allows for best practice and professional standards to be upheld.

    CPD can be undertaken through a variety of learning activities including instructor led training courses, seminars and conferences, e:learning modules or structured reading.

    CPD AND PROFESSIONAL INSTITUTES

    There are approximately 470 institutes in the UK across all industry sectors, with a collective membership of circa 4 million professionals, and they all expect their members to undertake CPD.

    For some institutes undertaking CPD is mandatory e.g. accountancy and law, and linked to a licence to practice, for others it’s obligatory. By ensuring that their members undertake CPD, the professional bodies seek to ensure that professional standards, legislative awareness and ethical practices are maintained.

    CPD Schemes often run over the period of a year and the institutes generally provide online tools for their members to record and reflect on their CPD activities.

    TYPICAL CPD SCHEMES AND RECORDING OF CPD (CPD points and hours)

    Professional bodies and Institutes CPD schemes are either structured as ‘Input’ or ‘Output’ based.

    ‘Input’ based schemes list a precise number of CPD hours that individuals must achieve within a given time period. These schemes can also use different ‘currencies’ such as points, merits, units or credits, where an individual must accumulate the number required. These currencies are usually based on time i.e. 1 CPD point = 1 hour of learning.

    ‘Output’ based schemes are learner centred. They require individuals to set learning goals that align to professional competencies, or personal development objectives. These schemes also list different ways to achieve the learning goals e.g. training courses, seminars or e:learning, which enables an individual to complete their CPD through their preferred mode of learning.

    The majority of Input and Output based schemes actively encourage individuals to seek appropriate CPD activities independently.

    As a formal provider of CPD certified activities, SAE Media Group can provide an indication of the learning benefit gained and the typical completion. However, it is ultimately the responsibility of the delegate to evaluate their learning, and record it correctly in line with their professional body’s or employers requirements.

    GLOBAL CPD

    Increasingly, international and emerging markets are ‘professionalising’ their workforces and looking to the UK to benchmark educational standards. The undertaking of CPD is now increasingly expected of any individual employed within today’s global marketplace.

    CPD Certificates

    We can provide a certificate for all our accredited events. To request a CPD certificate for a conference , workshop, master classes you have attended please email events@saemediagroup.com

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    Contact SAE Media Group

    UK Office
    Opening Hours: 9.00 - 17.30 (local time)
    SAE Media Group , Ground Floor, India House, 45 Curlew Street, London, SE1 2ND, United Kingdom
    Tel: +44 (0) 20 7827 6000 Fax: +44 (0) 20 7827 6001
    Website: http://www.smgconferences.com Email: events@saemediagroup.com
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